SLC35C2 promotes stemness and progression in hepatocellular carcinoma by activating lipogenesis.

Metabolic reprogramming plays a critical role in in tumorigenesis and progression, including hepatocellular carcinoma (HCC). The Solute Carriers (SLCs) family is responsible for the transport of a range of nutrients and has been linked to various cancers. Cancer stem cells (CSC) are a contributing factor to the recurrence and metastasis of HCC.

Erratum to 'B4GALNT1 promotes hepatocellular carcinoma stemness and progression via integrin α2β1-mediated FAK and AKT activation' (JHEP Reports 5 [2023] 100903).

[This corrects the article DOI: 10.1016/j.jhepr.

Teachers' Punishment Intensity and Student Observer Trust: A Moderated Mediation Model.

During social interactions, people decide whether to trust an actor based on their punitive behaviour. Several empirical studies have indicated that punishment intensity impacts observer trust, yet the underlying mechanism remains to be elucidated. This study included 242 junior high school students and was conducted to investigate the relationship between teachers' punishment intensity and levels of student bystander trust.

Visual analysis of trustworthiness studies: based on the Web of Science database.

Trustworthiness is the most significant predictor of trust and has a significant impact on people's levels of trust. Most trustworthiness-related research is empirical, and while it has a long history, it is challenging for academics to get insights that are applicable to their fields of study and to successfully transfer fragmented results into practice. In order to grasp their dynamic development processes through the mapping of network knowledge graphs, this paper is based on the Web of Science database and uses CiteSpace (6.

Group membership and adolescents' third-party punishment: a moderated chain mediation model.

Third-party punishment (TPP) reflects people's social preference for fairness norms and is fundamental to maintaining fairness norms on a large scale. Several empirical studies have shown that the offender's group membership impacts TPP, but the detailed mechanisms have yet to be fully elucidated. The current study used the third-party punishment game task to explore the relationship between group membership, perceived unfairness, anger, and adolescents' TPP.

Degradation Mechanism Study for Secondary Degradants in Rosuvastatin Calcium and Determination of Degradant Acetaldehyde Using Static Headspace Gas Chromatography Coupled with Matrix Precipitation.

During the development of headspace gas chromatography (HSGC) method for assessing residual solvents in rosuvastatin calcium (RSV) drug substance, acetaldehyde (AA) was detected in obtained chromatograms, with a calculated concentration of up to 226 ppm. After a series of experiments, it was established that acetaldehyde originates from matrix interference due to direct degradation of Imp-C, which is accompanied by the formation of impurity at relative retention time (RRT) 2.18, without the involvement of impurity at RRT 2.

CTCF modulates adipocyte lipolysis via directly regulating the expression of Beclin 1 with the cooperation of PPARγ.

Dysregulated lipolysis is a risk factor contributing to metabolic diseases and autophagy is known to be important in lipolysis. CTCF is involved in diverse cellular processes including adipogenesis, yet its role in lipolysis or autophagy remains unknown. We identified lipolytic genes were downregulated in CTCF knockdown adipocytes based on the RNA-seq data.

Traditional Chinese Medicine syndrome analysis on oxaliplatin-induced peripheral neuropathy and clinical efficacy of Bushen Yiqi formula: a prospective randomized controlled study.

Objectives: To analyze the distribution characteristics of Traditional Chinese Medicine (TCM) syndromes in patients with oxaliplatin-induced peripheral neuropathy (OIPN) and observe the clinical efficacy of Bushen Yiqi formula (, BSYQF) in treating patients with OIPN.

Methods: A total of 89 patients with OIPN were enrolled in this study. The TCM syndrome characteristics were investigated by frequency analysis methodology after collecting and analyzing the TCM syndrome elements of the patients with the OIPN TCM syndrome element scale.

Dark triad and cyber aggression among Chinese adolescents during COVID-19: A moderated mediation model.

During the COVID-19 pandemic, the use of online learning has become a necessary choice for students, and would increase the probability of cyber aggression (CA). Despite the relationship between Dark Triad and CA previous was explored in previous research, the underlying psychological mechanism of CA in adolescents is still unclear. The current study aimed to examine the mediating role of moral disengagement (MD) and the moderating of gender in the relationship between Dark Triad and CA.

Effects of Ingroup Identification on Ingroup Favouritism during Fairness Norm Enforcement.

People tend to voluntarily sacrifice their own interests to reject unfair proposals, and this behaviour is affected by group affiliation. While group bias is a well-established phenomenon, its direction is still unclear, and little attention has been given to possible moderating factors. In two studies, we manipulate participants' ingroup identification and investigate whether and how individuals with various levels of ingroup identification react differently to unfairness from ingroups and outgroups during an incentivized (Study 1, = 46) and hypothetical (Study 2, = 332) ultimatum game.

Gypenosides Attenuate Pulmonary Fibrosis by Inhibiting the AKT/mTOR/c-Myc Pathway.

Gypenosides (Gyps), the major active constituents isolated from , possess anti-inflammatory and antioxidant activities. Previous studies have demonstrated that Gyps displayed potent ameliorative effects on liver fibrosis and renal fibrosis. In this study, we found that Gyps significantly reduced the mortality of bleomycin-induced pulmonary fibrosis mice (40% mortality rate of mice in the model group versus 0% in the treatment group).

Victim Sensitivity and Proposal Size Modulate the Ingroup Favoritism During Fairness Norm Enforcement.

People show a strong aversion to inequality and are willing to sacrifice their own interests to punish violations of fairness norms. Empirical research has found that group membership could influence the fairness judgment and norm enforcement of the individuals but has shown inconsistent findings and has not focused much on the potential moderators. Here, the two studies aimed to investigate whether victim sensitivity and proposal size moderate the impact of group membership on reactions to unfair proposals.

Baicalin ameliorates cigarette smoke-induced airway inflammation in rats by modulating HDAC2/NF-κB/PAI-1 signalling.

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease distinguished by airway remodelling and progressive inflammation. PAI-1 is an important regulator of fibrosis. Recent studies have shown that PAI-1 seems to be involved in COPD progression.

"Want to Learn" and "Can Learn": Influence of Academic Passion on College Students' Academic Engagement.

Although research exists on the relationship between passion and engagement among employees, the mechanisms of academic passion on academic engagement among students needs to be elucidated. Guided by the broaden-and-build and situated cognition theories, we explored the positive effect of academic passion on academic engagement, the mediating effect of academic self-efficacy, and the role of teacher developmental feedback as a moderator in the relationship between academic passion and academic engagement. Based on a sample of 1,029 college students from universities in the Henan Province of China, the results showed that academic passion was positively related to academic engagement, academic self-efficacy partially mediated the relationship between academic passion and academic engagement, and teacher developmental feedback effectively moderated the relationship between academic passion and academic engagement.

Growth Mindset and College Students' Learning Engagement During the COVID-19 Pandemic: A Serial Mediation Model.

Against the scourge of the COVID-19 pandemic, college students' learning engagement has become a key issue in universities and society. Guided by the theories of existential positive psychology and social perception, we explored the positive effect of a growth mindset on learning engagement during the COVID-19 pandemic. A total of 1,040 college students from universities in Henan Province of China effectively completed online questionnaires.

Targeting ZEB2 By microRNA-129 In Non-Small Cell Lung Cancer Suppresses Cell Proliferation, Invasion And Migration Via Regulating Wnt/β-Catenin Signaling Pathway And Epithelial-Mesenchymal Transition.

Introduction: Non-small cell lung cancer (NSCLC) is a common cause of deaths all over the world. Emerging evidence has indicated that microRNA (miR) play key roles in NSCLC progression. We aimed to determine the functions of miR-129 in NSCLC.

Characteristics of the traditional Liu-Wei-Di-Huang prescription reassessed in modern pharmacology.

Liu-Wei-Di-Huang (LW) is a Yin nourishing and kidney tonifying prescription in traditional Chinese medicine with promising pharmacological characteristics that can be further exploited and developed in modern medicine. We provide a comprehensive and detailed literature report on the clinical and experimental pharmacology of LW, including its quality control parameters, phytochemistry, pharmacokinetics, and toxicology. Our literature review indicates that the LW prescription possesses a unique combination of pharmacological characteristics that can be safely used for treating very different diseases.

Efficacy of alemtuzumab and natalizumab in the treatment of different stages of multiple sclerosis patients.

Background: Multiple sclerosis (MS) is an autoimmune disease, in which the insulating covers of nerve cells in the brain and spinal cord are demyelinated. This study was conducted to compare the efficacy of alemtuzumab and natalizumab in the treatment of different stages of MS patients.

Methods: A total of 585 patients diagnosed with MS and hospitalized were included and analyzed after which they were divided into the primary progressive MS A and B groups, the relapsing-remitting MS (RRMS) C and D groups, and the secondary progressive MS E and F groups.

Toll-like receptor 4-related immunostimulatory polysaccharides: Primary structure, activity relationships, and possible interaction models.

Toll-like receptor (TLR) 4 is an important polysaccharide receptor; however, the relationships between the structures and biological activities of TLR4 and polysaccharides remain unknown. Many recent findings have revealed the primary structure of TLR4/MD-2-related polysaccharides, and several three-dimensional structure models of polysaccharide-binding proteins have been reported; and these models provide insights into the mechanisms through which polysaccharides interact with TLR4. In this review, we first discuss the origins of polysaccharides related to TLR4, including polysaccharides from higher plants, fungi, bacteria, algae, and animals.

Immune activities comparison of polysaccharide and polysaccharide-protein complex from Lycium barbarum L.

Lycium barbarum L., known as wolfberry, is an important Chinese herbal medicine. In the research, we purified water-soluble polysaccharide-protein complex (LBPF4) and polysaccharide (LBPF4-OL) from the fruiting bodies of L.

Lycium barbarum polysaccharide LBPF4-OL may be a new Toll-like receptor 4/MD2-MAPK signaling pathway activator and inducer.

Recognition of the utility of the traditional Chinese medicine Lycium barbarum L. has been gradually increasing in Europe and the Americas. Many immunoregulation and antitumor effects of L.

60 GHz millimeter-wave generator based on a frequency-quadrupling feed-forward modulation technique.

We propose and analyze a prototype of a 60 GHz millimeter-wave (mm-wave) generator. In the scheme, two lasers with a 70 GHz frequency interval serve as sources. Then a frequency-quadrupling feed-forward modulation technique is employed to generate two phase correlated sidebands with a 60 GHz interval.

Photonic frequency-quadrupling scheme for millimeter-wave generation by employing feed-forward modulation technique.

We theoretically analysis and numerically verify a frequency-quadrupling scheme which is capable of generating millimeter-wave (mm-wave) signals. The scheme is based on dual wavelength feed-forward modulation technique, which circumvents the need for direct modulation at mm-wave frequency band, providing potential for two-tone optical sources. The analytical models for transmission through a dispersive medium are confirmed by numerical simulations.