Publications by authors named "Chunhui Chen"

In an effort to balance energy and molecular stability effectively, several energetic compounds (-) based on benzotriazine were designed and synthesized. These structures were comprehensively characterized using NMR, IR, and elemental analysis, with compounds , , and further confirmed by single-crystal X-ray diffraction. Notably, 3-amino-5,7-dinitrobenzo[][1,2,4]triazine 1-oxide (), which features a face-to-face crystal stacking arrangement, exhibits good detonation velocity ( = 8050 m/s), a high thermal decomposition temperature ( = 290 °C), and low sensitivities (impact sensitivity >40 J, friction sensitivity >360 N).

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Background: Despite the widespread use in ischemic stroke, cancer, and malnutrition, the predictive ability of serum albumin to globulin ratio (A/G) among patients suffering from aneurysmal subarachnoid hemorrhage (aSAH) remains unknown. This study aimed to determine if serum A/G ratio is associated with the occurrence of delayed cerebral ischemia (DCI) after aSAH.

Methods: We retrospectively viewed the medical records of aSAH patients from 08/2017 to 08/2022.

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  • Three-dimensional solar steam evaporators are gaining attention for their effective water purification capabilities.
  • Researchers developed a new type of evaporator using elastic polymer covalent organic frameworks (PP-PEG) with outstanding light absorption and heat conversion features.
  • The innovative design achieves high evaporation rates, making it a promising solution for desalination and water purification, while being easy to produce and durable.
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  • The study investigates the role of the systemic inflammatory response index (SIRI) in predicting the risk of stroke-associated pneumonia (SAP) in patients who have undergone thrombectomy for acute ischemic stroke (AIS).
  • Researchers analyzed 84 AIS patients treated with thrombectomy, finding that 66.7% developed SAP, with significant predictors identified including SIRI and age.
  • The results suggest that SIRI is a strong independent predictor for SAP, helping medical professionals identify high-risk AIS patients early based on their SIRI values.
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Background: In 2009, the clinical practice guidelines (CPG) were released by the American Academy of Orthopaedic Surgeons (AAOS), which outline an age-based approach for treating pediatric femoral shaft fractures (PFSF), both nonoperatively and operatively. The aim of the current study was to investigate potential disparities between the recommended treatments for PFSF based on the AAOS-CPG and the actual treatments administered in The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University.

Methods: A retrospective review was conducted on the medical charts and radiographs of all PFSF treated at The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University from January 2014 to January 2022.

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Objective: Glioma is a leading cause of mortality worldwide, its recurrence poses a major challenge in achieving effective treatment outcomes. Cancer stem cells (CSCs) have emerged as key contributors to tumor relapse and chemotherapy resistance, making them attractive targets for glioma cancer therapy. This study investigated the potential of FERMT1 as a prognostic biomarker and its role in regulating stemness through cell cycle in glioma.

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Regressing the accelerated degradation of skeletal muscle protein is a significant goal for cancer cachexia management. Here, we show that genetic deletion of ameliorates skeletal muscle atrophy in various tumor-bearing mice. ablation represses excessive myoblast mitophagy and effectively suppresses mitochondria meltdown and muscle wastage.

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Two 6,5,6-fused 1,2,3-triazine-3-oxides ( and ) were designed and synthesized via the reaction of -aminoamidoximes with sodium nitrite. In addition, the ring-opening products (, , and ) derived from 1,2,3-triazine-3-oxides were isolated and characterized. A comprehensive exploration of the reaction mechanism governing the ring-opening process was performed through a combination of theoretical and experimental studies.

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Decreased levels of β-hydroxybutyrate (BHB), a lipid metabolic intermediate known to slow the progression of colorectal cancer (CRC), have been observed in the colon mucosa of patients with inflammatory bowel diseases (IBD). In particular, patients with recurrent IBD present an increased risk of developing colitis-associated colorectal cancer (CAC). The role and molecular mechanism of BHB in the inflammatory and carcinogenic process of CAC remains unclear.

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Purpose: To explore whether it is necessary to put drain tubes after posterior pedicle screw fixation of thoracolumbar fractures.

Methods: From April 2020 to January 2023, a total of 291 patients with recent thoracolumbar fractures (AO type-A or type-B) who received the pedicle screw fixation operation were enrolled retrospectively. In 77 patients, drain tubes were used in the pedicle screw fixation surgery, while no drain tubes were placed in the other group.

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Article Synopsis
  • Thermochemical water-splitting cycles can produce hydrogen but face challenges due to their high operating temperatures and low efficiency.
  • A new method for thermocatalytic water-splitting is introduced, utilizing single atomic platinum on defective indium oxide at water boiling temperatures, achieving a production rate of 36.4 mmol·h·g.
  • The study highlights how specific catalytic formations enhance the water dissociation process, creating potential for hydrogen production from low-grade heat, posing a competitive alternative to other hydrogen production methods.
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Machine learning is an emerging tool in clinical psychology and neuroscience for the individualized prediction of psychiatric symptoms. However, its application in non-clinical populations is still in its infancy. Given the widespread morphological changes observed in psychiatric disorders, our study applies five supervised machine learning regression algorithms-ridge regression, support vector regression, partial least squares regression, least absolute shrinkage and selection operator regression, and Elastic-Net regression-to predict anxiety and depressive symptom scores.

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Background: Stem cell therapy on ischemic stroke has long been studied using animal experiments. The efficacy and safety of this treatment in ischemic stroke patients remain uncertain.

Methods: We searched for all clinical randomized controlled trials published before October 2023, on PubMed, EMBASE, and the Cochrane Library using predetermined search terms, and performed a meta-analysis of the efficacy of stem cell therapy in ischemic stroke patients.

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Objective: To investigate whether the number of years of schooling are causally associated traumatic brain injury (TBI). We aimed to investigate whether the number of years of schooling are causally associated TBI.

Methods: We investigate the prospective causal effect of years of schooling on TBI using summary statistical data.

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Background: Implant choice for the fixation of femoral neck fracture is one of the most important management controversies. This study aims to evaluate and compare the short-term outcomes associated with the use of the Femoral Neck System (FNS), Multiple Cancellous Screws (MCS), and Dynamic Hip Screws (DHS) in treating femoral neck fractures in a young patient population.

Methods: From June 2018 to June 2021, a total of 120 surgeries for a primary femoral neck fracture were retrospectively analyzed.

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Colorectal cancer (CRC) is the most prevalent malignancy of the digestive system. Glucose metabolism plays a crucial role in CRC development. However, the heterogeneity of glucose metabolic patterns in CRC is not well characterized.

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Conductive ink deposited on flexible substrates through simple methods such as dyeing or printing is one of the most promising approaches for scalable fabrication of wearable electronics. However, excessive chemical additives or a complex preparation process has limited the practical applications of conductive inks. Herein, a highly stable and antibacterial AgNPs/CNT/rGO (SACR) conductive ink with the only assistance of sustainable silk sericin (SS) is developed through a green one-step strategy.

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This study explored whether amygdala reactivity predicted the greed personality trait (GPT) using both task-based and resting-state functional connectivity analyses (n = 452). In Cohort 1 (n = 83), task-based functional magnetic resonance imaging (t-fMRI) results from a region-of-interest (ROI) analysis revealed no direct correlation between amygdala reactivity to fearful and angry faces and GPT. Instead, whole-brain analyses revealed GPT to robustly negatively vary with activations in the right ventromedial prefrontal cortex (vmPFC), supramarginal gyrus, and angular gyrus in the contrast of fearful + angry faces > shapes.

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Introduction: The use of magnesium sulfate for treating aneurysmal subarachnoid hemorrhage (aSAH) has shown inconsistent results across studies. To assess the impact of magnesium sulfate on outcomes after aSAH, we conducted a systematic review and meta-analysis of relevant randomized controlled trials.

Methods: PubMed, Embase, and the Cochrane Library were searched for relevant literature on magnesium sulfate for aSAH from database inception to March 20, 2023.

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Background: N6-methyladenosine (mA) RNA modification regulators play an important role in many human diseases, and its abnormal expression can lead to the occurrence and development of diseases. However, their significance in pulpitis remains largely unknown. Here, we sought to identify and validate the mA RNA regulatory network in pulpitis.

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Organic amine (R-NH) reagents as dominant chemical sorbents for CO capture in industrial processes suffer from high energy compensation for regeneration. Herein, we, for the first time, report the finding of Co(III) coordinating with NH molecules regulating the interaction between NH and CO to electrostatic interactions instead of a chemical reaction and achieve CO capture under near-ambient conditions. NH coordinating with Co(III) significantly reduces its alkalinity and reactivity with CO owing to its lone-pair electron donation during coordination.

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Objective: Impulsivity is influenced by genetic, neural, and environmental factors, but no study has examined how these factors work together to generate individual differences in impulsivity. The present study aimed to define the functional network that subserves impulsivity and test its relations with the gene-environment interactions found in the gene-environment-wide interaction study.

Method: This study used a sample of healthy Chinese college students ( = 1,145) to identify gene-environment interactive effects on impulsivity, then defined the functional brain network related to impulsivity in an independent sample ( = 483), and explored the gene-brain associations using polygenic risk score.

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Glioma is a highly aggressive primary malignant tumor. Migration-inducing gene-7 (Mig-7) is closely related to tumor invasion and metastasis. However, the detailed molecular mechanism of Mig-7-mediated promotion of glioma cell invasion requires further investigation.

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Several studies have examined the neural substrates of probabilistic decision-making, but few have systematically investigated the neural representations of the two objective attributes of probabilistic rewards, that is, the reward amount and the probability. Specifically, whether there are common or distinct neural activity patterns to represent the objective attributes and their association with the neural representation of the subjective valuation remains largely underexplored. We conducted two studies (n  = 34, n  = 41) to uncover distributed neural representations of the objective attributes and subjective value as well as their association with individual probability discounting rates.

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