Distribution Characteristics of ANA and ANCA in Patients with Hyperthyroidism.

Background: Antinuclear antibody (ANA) and Antineutrophil autoantibodies (ANCA) are often used as markers for the diagnosis of autoimmune diseases. In clinical practice, we have found that ANA and ANCA often occur in sera of patients with hyperthyroidism.

Objective: The study aimed to discover the positive features of anti-nuclear antibodies (ANA) and anti-neutrophil cytoplasmic antibodies (ANCA) in hyperthyroidism.

Circulating RBP4 Increase and Its Diagnosis of Chronic Kidney Disease.

Objective: Sera retinol binding protein 4 (RBP4) has been associated with renal function. We determined the concentration of sera RBP4 in chronic kidney disease (CKD) and found its diagnostic value for CKD.

Materials And Methods: The sera samples were collected from 51 patients with CKD and 30 healthy control.

Potential Role of Soluble TNF-α Receptors in Diagnosis of Patients with Chronic Kidney Disease.

Objective: Soluble tumor necrosis factor α (TNF-α) receptors contain two subclasses: soluble tumor necrosis factor receptor (sTNFR)1 and sTNFR 2. The aim of our study was to investigate whether serum levels of them are biomarkers for diagnosis of chronic kidney disease (CKD) patients.

Materials And Methods: The serum samples were collected from 51 patients with CKD and 30 healthy controls.

Comparison of biomarkers between PLA2RAb+ and PLA2RAb- in patients with idiopathic membranous nephropathy.

Objective: The presence of antibodies against the M-type phospholipase A2 receptor (PLA2RAb) is considered to be a promising serological diagnostic biomarker of idiopathic membranous nephropathy (IMN). We compare the change in serum Cystain C (CysC), urea, creatinine (CREA), uric acid (UA), total protein (TP), albumin (ALB), IgG4 and 24-h urinary protein (proteinuria, PRO) between PLA2RAb+ and PLA2RAb- of IMN patients.

Materials And Methods: The serum and urine samples were collected from 120 patients with IMN.

Potential role of adenosine deaminase in the diagnosis of adult-onset Still's disease.

Adult-onset Still's disease (AOSD) is a systemic inflammatory autoimmune disorder of unknown etiology and pathogenesis. There are no specific laboratory tests for AOSD. To investigate the potential role of adenosine deaminase (ADA) in the diagnosis of AOSD and analyze the correlation among ADA, LDH and WBC (white blood cell count), the serum levels of ADA and LDH in 26 patients with active untreated AOSD, 40 patients with active systemic lupus erythematosus (SLE) as disease control and 48 healthy volunteers as healthy control were determined using automatic biochemical analyzer (Olympus AU2700, Japan).

Comparison of serological markers between ACPA⁺ and ACPA⁻ of RA patients.

Unlabelled: Anti-citrullinated protein/peptide antibodies (ACPA) have recently emerged as sensitive and specific serological markers of rheumatoid arthritis (RA), providing superior alternative of the rheumatoid factor (RF) test in the laboratory diagnostics of RA. We compare the change of serum RF, CRP, IgG, IgM, IgA, total complement, C3 and C4. The sera sample was collected from 123 patients with RA.

Expression of hepaCAM and its effect on proliferation of tumor cells in renal cell carcinoma.

Objectives: To evaluate hepaCAM (hepatocyte cell adhesion molecule) gene expression in patients with renal cell carcinoma (RCC) and to explore its effect on proliferation of 786-0 cells. hepaCAM is a tumor suppressor gene, which has been identified as a member of immunoglobulin superfamily cell adhesion molecule.

Methods: Two-step reverse transcription-polymerase chain reaction was used to determine hepaCAM expression in 30 paired (RCC and the adjacent non-RCC) renal specimens.