Role of RGS2 in sevoflurane-induced cognitive dysfunction in aged rats.

After undergoing inhalation anesthesia, some patients, especially elderly patients, experience postoperative cognitive dysfunction, such as personality changes and memory impairment. In the present study, 20-month-old rats were randomly allocated to sevoflurane (Sevo group) and control groups (Con group), and they inhaled 3% sevoflurane or 40% oxygen for 8 hours, respectively. The Morris water maze test found that the cognitive function of rats in the Sevo group were significantly different on 1d and 3d after anesthesia than that of rats in the Con group.

Clinical Value of Controlling Nutritional Status Score in Patients with Aneurysmal Subarachnoid Hemorrhage.

Objective: The aim of present study was to assess the predictive value of the admission prognostic nutrition index (PNI), controlling nutritional status (CONUT) associated with delayed cerebral ischemia (DCI), and 3-month neurological outcomes after aneurysmal subarachnoid hemorrhage (aSAH).

Methods: The clinical data from 252 patients with aSAH were retrospectively analyzed. Receiver operating characteristic analysis was performed to assess the predictive ability of the PNI and CONUT score and identify the cutoff point.

The role of propofol on mouse oocyte meiotic maturation and early embryo development.

SummaryPropofol is a intravenous anaesthetic most commonly used in ultrasound oocyte retrieval. We studied if the use of propofol had an effect on mouse oocyte maturation, pregnancy, childbirth and progeny and investigated the correlation between propofol side effects and reproductive performance in mice. There was no statistical difference in mating, pregnancy, childbirth, litter size, the number of stillbirths and survival between each group (P>0.

Application of Heparinized Selective Acellular Sheepskin in Wound-healing Promotion of Deep Second-degree Burns.

Introduction: This study investigated the application of selective sheepskin acellular dermal matrix (ADM), combined with the anticoagulant heparin, in the wound-healing treatment of deep second-degree burns (DSDB).

Methods: A DSDB model was established, and the test animals were randomly divided into 4 groups: iodophor gauze (IG), pig ADM (PA), selective sheepskin ADM (SSA), and heparinized selective sheepskin ADM (HSSA).The microcirculation of the wound surface, pathological structures, healing rates, and fibroblast apoptosis rates were observed at different times in each group.

Sodium Channel Voltage-Gated Beta 2 Plays a Vital Role in Brain Aging Associated with Synaptic Plasticity and Expression of COX5A and FGF-2.

The role of sodium channel voltage-gated beta 2 (SCN2B) in brain aging is largely unknown. The present study was therefore designed to determine the role of SCN2B in brain aging by using the senescence-accelerated mice prone 8 (SAMP8), a brain senescence-accelerated animal model, together with the SCN2B transgenic mice. The results showed that SAMP8 exhibited impaired learning and memory functions, assessed by the Morris water maze test, as early as 8 months of age.

[Study of apoptosis related factors regulatory mechanism of resveratrol to human skin squamous cell carcinoma A431 xenograft in nude mice].

Objective: To explore the anti-tumor effects of resveratrol (Res) upon human skin squamous cell carcinoma A431 xenograft in nude mice and elucidate the regulatory mechanisms of survivin and caspase-3.

Methods: The model of human skin squamous cell carcinoma (A431) xenograft in nude mice was established. And the animals were randomly divided into saline-negative control, cyclophosphamide (CTX) positive control, Res high-, medium- and low-dosage and blank control groups (n = 10 each).

The inhibition of resveratrol to human skin squamous cell carcinoma A431 xenografts in nude mice.

Squamous cell carcinoma (SCC) is one of the commonest dermatological malignancies. Resveratrol (Res) is one type of polyphenolic compound which was first identified from the roots of Veratrum grandinorum in 1940. The previous studies found that Res can promote apoptosis of a variety of tumor cell, especially SCC cells.

Recombinant DNA vaccine against inhibition of neurite outgrowth promotes functional recovery associated with endogeous NGF expression in spinal cord hemisected adult rats.

Axonal regeneration across the site of spinal cord lesion is often aborted in adult mammalian species. The use of DNA vaccine to nullify the inhibitory molecules has been shown to be effective in promoting axonal regeneration in injured spinal cord. The possible molecular mechanisms, however, remain to be elucidated.

Roles of platelet-derived growth factor-B expression in the ventral horn and motor cortex in the spinal cord-hemisected rhesus monkey.

It is well known that platelet-derived growth factor-B (PDGF-B), a member of the neurotrophic factor family, is involved in normal physiological conditions, pathological changes, and neuroregulation following lesions. But the roles of endogenous PDGF-B in neuroregulation following spinal cord injury are far from being well known, especially in primates. This study explored the role of PDGF-B in the spinal cord and motor cortex in rhesus monkeys subjected to cord hemisection.