Publications by authors named "Chunge Cao"
Introduction: The relationship between serum uric acid (SUA) and cervical cancer is inconclusive. This study aims to investigate the causal relationship between SUA levels and cervical cancer incidence, and to evaluate the potential role of nutritional interventions in cervical cancer prevention.
Methods: We conducted a two-sample bidirectional Mendelian randomization (MR) analysis using genetic instruments from publicly available genome-wide association studies (GWASs) of individuals of predominantly European ancestry.
Purpose: To investigate the potential causal association between COVID-19 exposure and optic nerve and visual pathway disorders through a two-sample bidirectional Mendelian randomization (MR) analysis, and to provide empirical support for the lung-brain axis.
Methods: This MR analysis utilized publicly accessible summary-level data from genome-wide association studies on COVID-19 (n=158,783) and optic nerve and visual pathway diseases (n=412,181), primarily involving individuals of European descent. The random-effect inverse-variance weighted estimation was applied as the main analytical approach, complemented by MR-Egger, weighted median, and weighted mode methods.
Prenatal whole-exome sequencing in fetuses with increased nuchal translucency.
Mol Genet Genomic Med
November 2023
Background: Increased nuchal translucency (NT) is associated with an increased risk for genetic disorders. The aim of this study was to investigate the value of whole-exome sequencing (WES) in detecting genetic abnormalities for fetuses with isolated first-trimester increased NT.
Methods: After the exclusion of aneuploidies and pathogenic copy number variants (CNVs) by quantitative fluorescent polymerase chain reaction (QF-PCR) and chromosomal microarray analysis (CMA), WES was performed on 63 fetuses with isolated first-trimester increased NT (≥3.
Article Synopsis
- * Researchers developed a new method using high-resolution melting curve (HRM) analysis to quickly and accurately test for these genetic variations in a single tube, making the process easier.
- * The accuracy of this HRM method was confirmed by comparing it with traditional DNA sequencing, indicating it could be useful in clinical settings for personalized clopidogrel dosing based on genetic makeup.
[Change in ambulatory arterial stiffness index with advancing age and the correlation with 24 hours pulse pressure in healthy individuals].
Zhonghua Xin Xue Guan Bing Za Zhi
August 2009
Objective: Ambulatory arterial stiffness index (AASI) has been recently proposed to reflect the dynamic relation between diastolic and systolic blood pressure throughout the whole day. The aim of our study was to investigate the change in AASI with advancing age and the correlation with 24 hours pulse pressure (24 h PP) in healthy individuals.
Methods: 246 healthy subjects [mean age (59.