Synopsis of recent research by authors named "Chung-Pu Wu"
- Chung-Pu Wu's research primarily focuses on overcoming multidrug resistance (MDR) in cancer therapy, particularly through the modulation of ATP-binding cassette (ABC) transporters such as ABCB1 and ABCG2, which play significant roles in the efflux of anticancer drugs from cancer cells.
- Recent findings highlight various drug repositioning strategies, including the use of existing inhibitors and bioactive compounds to enhance the chemosensitivity of multidrug-resistant cancer cells, thereby improving the efficacy of conventional chemotherapy.
- Wu's studies emphasize the urgent need for effective treatments against MDR cancers due to the lack of approved therapeutic agents targeting these resistance mechanisms, advocating for innovative approaches that leverage drug repurposing to combat this critical challenge.
