Publications by authors named "Chung-An Fang"
Article Synopsis
- Carfentanil ([C]CFN) is the only carbon-11 labeled radiotracer used for PET imaging of mu opioid receptors, but its effects in preclinical studies haven't been fully explored.
- In studies with anesthetized rats, researchers found that higher doses of CFN led to significant changes in vital signs and a correlation between CFN mass and mu opioid receptor availability in the brain.
- The results suggest that controlling CFN dosage is crucial to avoid complications and accurately measure mu opioid receptor activity, highlighting the need for careful quality control in PET studies with this radiotracer.
Cancer Lett
November 2012
Article Synopsis
- HER2-overexpressing cancer cells show resistance to common chemotherapy drugs, cisplatin (CDDP) and doxorubicin (DXR).
- The SV40 T/t-common polypeptide can make these resistant cancer cells more sensitive to CDDP and DXR, leading to increased cell death (apoptosis).
- T/t-common works by inhibiting proteins Bcl-2 and Bcl-XL, and reducing ERK activity, suggesting that combining T/t-common with these chemotherapies could improve treatment outcomes for HER2-overexpressing cancers, as demonstrated in mouse models.
