Publications by authors named "Chung T K Le"
Vimentin binds IRAP and is involved in GLUT4 vesicle trafficking.
Biochem Biophys Res Commun
February 2011
Article Synopsis
- Insulin-responsive aminopeptidase (IRAP) and GLUT4 are crucial proteins involved in the movement of GLUT4 storage vesicles (GSVs) to the cell surface in response to insulin.
- The study identified vimentin as a protein that interacts with the cytoplasmic region of IRAP, supporting the idea that IRAP helps keep GSVs in place.
- Vimentin depletion in adipocytes led to reduced GLUT4 translocation to the plasma membrane, indicating that vimentin is key for maintaining GSV retention near the cytoskeleton.