Publications by authors named "Chung Seok Lee"

Article Synopsis
  • - The study focuses on spinal muscular atrophy (SMA), a genetic disease that results in the loss of motor neurons, leading to muscle weakness, and examines the diagnostic process for Korean SMA patients over 23 years.
  • - In a review of 38 patients, it was found that the average age for symptom onset was 3 years, but diagnosis occurred much later at 25 years, with a notable delay of approximately 19.6 years, particularly longer for type III SMA patients.
  • - The research emphasizes the importance of improving diagnostic accuracy for SMA as treatment options evolve, marking a significant exploration of the diagnostic journey for patients in Korea.
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Bickerstaff's brainstem encephalitis is a rare autoimmune disorder that presents with ataxia, ophthalmoplegia, disturbance of consciousness and quadriplegia. A 45-year-old man with a history of ulcerative colitis (UC) taking mesalazine (5-aminosalicylic acid) visited the emergency room presenting with ataxia, ophthalmoplegia and a progressively worsening cognitive impairment. Cerebrospinal fluid analysis showed mild elevation in protein and white blood cell count and increased intracranial pressure.

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Snapping hip syndrome is a relatively common problem that can be easily managed with conservative treatment. This syndrome can be divided into external, internal and intra-articular types. Internal snapping hip syndrome is the rarest amongst these and its etiology is not well understood.

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The present study examined the effect of MAO inhibitors, deprenyl and harmaline, on the membrane permeability transition in brain mitochondria. Deprenyl, harmaline, and antioxidant enzymes (SOD and catalase) attenuated alteration of the swelling, membrane potential, cytochrome c release, and Ca2+ transport in mitochondria treated with dopamine. In contrast, deprenyl and harmaline did not reduce the peroxynitrite-induced change in membrane permeability.

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