Low Thermal Conductivity and Diffusivity at High Temperatures Using Stable High-Entropy Spinel Oxide Nanoparticles.

The realization of low thermal conductivity at high temperatures (0.11 W m K 800 °C) in ambient air in a porous solid thermal insulation material, using stable packed nanoparticles of high-entropy spinel oxide with 8 cations (HESO-8 NPs) with a relatively high packing density of ≈50%, is reported. The high-density HESO-8 NP pellets possess around 1000-fold lower thermal diffusivity than that of air, resulting in much slower heat propagation when subjected to a transient heat flux.

Fabrication of bio-mimic nanozyme based on Mxene@AuNPs and molecular imprinted poly(thionine) films for creatinine detection.

Creatinine (Ctn) is a biomarker for chronic kidney disease (CKD). In this study, a highly sensitive and specific detection method for Ctn based on a molecularly imprinted polymer (MIP) based electrochemical biosensor was developed. Mxene (Mx), which has high absorption properties, was modified using carbon screen-printed electrodes (SPCE).

Optimal tissue acquisition method for pancreatic mass.

Pancreatic masses pose a diagnostic difficulty due to the technical complexities related to tissue acquisition. Endoscopic ultrasound (EUS)-guided tissue acquisition has transformed the field by allowing access to pancreatic lesions through fine-needle and biopsy. However, diagnostic accuracy differs based on tumor characteristics and procedural factors.

Clinical importance of patient-reported outcome measures in severe asthma: results from U-BIOPRED.

Rationale: Knowledge about the clinical importance of patient-reported outcome measures (PROMs) in severe asthma is limited.

Objectives: To assess whether and to what extent asthma exacerbations affect changes in PROMS over time and asthma-specific PROMs can predict exacerbations in adult patients with severe asthma in usual care.

Methods: Data of 421 patients with severe asthma (62% female; mean age 51.

Association between allostatic load and cardiac structural and functional abnormalities in young adults with serious mental disorders.

Objective: Allostatic load refers to the pathophysiological consequences of uncompensated adaptation to chronic stress. Few studies have investigated the effect of allostatic load on cardiac health in patients with serious mental disorders (SMDs), a population at high risk of cardiac mortality. Herein we evaluated associations between allostatic load and cardiac structure and function in young adults with SMDs.

A device-dependent auto-segmentation method based on combined generalized and single-device datasets.

Background: Although generalized-dataset-based auto-segmentation models that consider various computed tomography (CT) scanners have shown great clinical potential, their application to medical images from unseen scanners remains challenging because of device-dependent image features.

Purpose: This study aims to investigate the performance of a device-dependent auto-segmentation model based on a combined dataset of a generalized dataset and single CT scanner dataset.

Method: We constructed two training datasets for 21 chest and abdominal organs.

Graft Length Changes and Optimal Knee Flexion Angles for Fixation in Posterolateral Corner Reconstruction: An In Vivo 3-Dimensional Simulation Analysis.

Background: Changes in graft length according to knee flexion and the ideal knee flexion angle at the time of graft fixation for posterolateral corner (PLC) reconstruction have yet to be clearly defined.

Purposes: To investigate graft length changes according to knee flexion and determine the optimal graft fixation angle for knee flexion in PLC reconstruction.

Study Design: Descriptive laboratory study.

Extreme temperature increases the risk of COPD morbimortality: A systematic review and meta-analysis.

Introduction: This systematic review examines how extreme temperatures impact chronic obstructive pulmonary disease (COPD) morbidity and mortality, focusing on identifying vulnerable subpopulations.

Methods: We conducted a systematic literature search from January 1, 2000, to November 6, 2024, across databases like PubMed, MEDLINE and EMBASE, Web of Science, and Scopus, focusing on observational studies that quantitatively defined extreme temperatures and their impacts on COPD morbidity and mortality. Out of 3140 records, 25 studies met the inclusion criteria.

Preliminary Report Examining Efficacy and Safety of Radiofrequency Ablation for the Treatment of Skin-Involving Recurrent Thyroid Cancer.

This study assessed the efficacy and safety of ultrasound (US)-guided radiofrequency ablation (RFA) for treatment of skin-involving recurrent thyroid cancer. In this retrospective case series study, 43 patients (mean age: 67.9 ± 14.

Bayesian Reanalysis of Statistically Nonsignificant Outcomes in Plastic Surgery Clinical Trials.

Background: Statistically nonsignificant randomized clinical trial (RCT) results are challenging to interpret, as they are unable to prove the absence of a difference between treatment groups. Bayesian analysis offers an alternative statistical framework capable of providing a comprehensive understanding of nonsignificant results.

Methods: This cross-sectional study conducted a post hoc Bayesian analysis of statistically nonsignificant outcomes from RCTs published in from 2013 to 2022.

Comparison of Postoperative Breast Asymmetry Using Vectra 3D Imaging in Prepectoral Versus Subpectoral Implant-Based Breast Reconstruction.

Implant-based breast reconstruction (IBBR) is increasingly favored over autologous reconstruction due to its procedural simplicity and recovery benefits. Conducting this reconstruction using either the subpectoral or prepectoral planes has varied aesthetic outcomes. This study utilizes VECTRA XT 3D imaging to objectively assess breast symmetry differences between these surgical techniques.

Single-cell RNA sequencing reveals transcriptional changes in circulating immune cells from patients with severe asthma induced by biologics.

Patients with severe eosinophilic asthma often require systemic medication, including corticosteroids and anti-type 2 (T2) cytokine biologics, to control the disease. While anti-IL5 and anti-IL4Rα antibodies suppress the effects of IL-4, IL-5 and IL-13, the molecular pathways modified by these biologics that are associated with clinical improvement remain unclear. Therefore, we aimed to describe the effects of T2-targeting biologics on the gene expression of blood immune cells.

Evaluating multiple sclerosis severity loci 30 years after a clinically isolated syndrome.

The first genome-wide significant multiple sclerosis severity locus, rs10191329, has been pathologically linked to cortical lesion load and brain atrophy. However, observational cohorts such as MSBase have not replicated associations with disability outcomes, instead finding other loci. We evaluated rs10191329 and MSBase loci in a unique cohort of 53 people followed for 30 years after a clinically isolated syndrome, with deep clinical phenotyping and MRI measures of inflammation and neurodegeneration.

Impact of daily neighborhood crime on nightly sleep among adolescents.

Crime impacts both the immediate victims and has indirect effects on the community. This study examined associations between daily neighborhood crime and actigraphy-assessed sleep outcomes using multilevel modeling. Data were from a longitudinal (14-day) study of 288 adolescents (M = 15.

The Effect of Inhaled Beta-2 Agonists on Heart Rate in Patients With Asthma: Sensor-Based Observational Study.

Background: Beta-2 agonists play an important role in the management of asthma. Inhaled long-acting beta-2 agonists (LABAs) and short-acting beta-2 agonists (SABAs) cause bronchodilation by stimulating adrenoceptors. These receptors are also present in cardiac cells and, as a side effect, could also be stimulated by inhaled beta-2 agonists.

Erratum: Naphthalene-based fluorescent probes for glutathione and their applications in living cells and patients with sepsis: Erratum.

[This corrects the article DOI: 10.7150/thno.22252.

Evaluation of the Effect of Precursor NMC622@TiO Core-Shell Powders Using a Prelithiated Anode from Fig Seeds: Spotlight on Li-ion Full-Cell Performance.

In this study, innovative electrode materials for lithium-ion batteries (LIBs) were developed and characterized, demonstrating significant performance enhancements. Initially, NMC622@TiO was synthesized using a wet-chemical method with titanium(IV) ethoxide as the Ti source. Advanced structural investigations confirmed the successful formation of a core@shell structure with negligible cation mixing (Li/Ni) at the NMC622 surface, contributing to enhanced electrochemical performance.

Prediction of 12-Month Clinical Outcomes Postsurgery Based on 3-Month Knee Examination After Primary Anterior Cruciate Ligament Reconstruction.

Context: Active management of modifiable factors during the early rehabilitation stage can help patients who have undergone anterior cruciate ligament (ACL) reconstruction successfully return to sports. This study aimed to determine predictors for performance on the single-leg hop test and Tegner activity score 12-month post-ACL reconstruction, based on knee function assessed 3-month postsurgery.

Design: Prospective cohort study.

Dopamine-conjugated extracellular vesicles induce autophagy in Parkinson's disease.

The application of extracellular vesicles (EVs) as vehicles for anti-Parkinson's agents represents a significant advance, yet their clinical translation is hampered by challenges in efficient brain delivery and complex blood-brain barrier (BBB) targeting strategies. In this study, we engineered dopamine onto the surface of adipose-derived stem cell EVs (Dopa-EVs) utilizing a facile, two-step cross-linking approach. This engineering enhanced neuronal uptake of the EVs in primary neurons and neuroblastoma cells, a process shown to be competitively inhibited by dopamine pretreatment and dopamine receptor antibodies.

Longitudinal multi-trajectory phenotypes of severe eosinophilic asthma on type 2 biologics treatment.

Background: Limited understanding exists regarding the progression trajectory of severe eosinophilic asthma (SEA) patients on type 2 biologics therapies.

Objective: We aim to explore distinct longitudinal phenotypes of these patients based on crucial asthma biomarkers.

Methods: We enrolled 101 adult patients with SEA.

Toll-like receptor 3 signaling attenuated colitis-associated cancer development in mice.

Inflammatory bowel disease is associated with a high risk of colitis-associated cancer (CAC). We evaluated the role of TLR3 in CAC using a murine model. Wild-type (WT) and TLR3-knockout (TLR3) mice received azoxymethane (AOM) 12.

Outcomes of all-dorsal augmented intercarpal ligament reconstruction (ADAIR).

Background: Scapholunate (SL) and lunotriquetral (LT) ligament injuries are frequently undiagnosed and can lead to progressive loss of wrist function and chronic pain. Many surgical reconstruction options exist, but outcomes are suboptimal and no superior approach has been established.

Methods: Consecutive candidates for SL and/or LT ligament reconstruction utilizing an all-dorsal augmented intercarpal ligament reconstruction (ADAIR) were evaluated in this prospective case series.