Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis.

Periodontitis is an infectious disease whereby the chronic inflammatory process of the periodontium stimulated by bacterial products induces specific host cell responses. The activation of the host cell immune system upregulates the production of inflammatory mediators, comprising cytokines and proteolytic enzymes, which contribute to inflammation and bone destruction. It has been well known that periodontitis is related to systemic inflammation which links to numerous systemic diseases, including diabetes and arteriosclerosis.

[Comparison of short-term clinical effect and assessment of influencial factors around single-tooth in the aesthetic area: immediate implant placement versus delayed implant placement].

Purpose: To compare the short-term clinical effect and to assess the influencial factors of immediate implant placement and delayed implant placement around single-tooth implant in the aesthetic area.

Methods: A total of 114 patients requiring a single-tooth implant in the aesthetic area were reviewed at Center for Implant Dentistry of Stomatological Hospital of China Medical University. They were divided into immediate implant group and delayed implant group.

Boi-ogi-to (TJ-20), a Kampo Formula, Suppresses the Inflammatory Bone Destruction and the Expression of Cytokines in the Synovia of Ankle Joints of Adjuvant Arthritic Rats.

TJ-20 is a formula consisting of 6 herbs that has been used in the clinical treatment of rheumatoid arthritis (RA) in China and Japan for centuries. However, scientific evidence of the effects of TJ-20 has not been established. In the present study, we focused on the therapeutic effects and investigated the main function of TJ-20 on adjuvant arthritis (AA), an animal model of RA, which was induced with complete Freund's adjuvant (CFA).

Assessment of implant cumulative survival rates in sites with different bone density and related prognostic factors: an 8-year retrospective study of 2,684 implants.

Purpose: This retrospective study was set to explore the influence of local bone density (BD) on implant cumulative survival rates (ICSRs) and to assess prognostic factors associated with implant failure at sites with different BD.

Materials And Methods: Between January 2005 and December 2011, 2,684 implants were placed in 1,377 patients and included in the study. Implants at sites with different BD were divided into four groups (G1 to G4) according to the Lekholm and Zarb classification, corresponding to bone types 1 to 4.

Dormancy activation mechanism of oral cavity cancer stem cells.

Radiotherapy and chemotherapy are targeted primarily at rapidly proliferating cancer cells and are unable to eliminate cancer stem cells in the G0 phase. Thus, these treatments cannot prevent the recurrence and metastasis of cancer. Understanding the mechanisms by which cancer stem cells are maintained in the dormant G0 phase, and how they become active is key to developing new cancer therapies.

[A clinical retrospective analysis of dental implants replaced in previously failed sites].

Purpose: To evaluate the clinical outcomes as well as related factors of dental implants replaced in previously failed sites.

Methods: A total of 12 patients (15 implants) who received replacement in previously failed sites during January 2005 to December 2011 were included. Outcomes of redo-implants were collected and clinical data was recorded and analyzed regarding risk factors related to redo-implants' survival using SPSS13.

[An assessment of different crown-to-implant ratio for implant teeth in the posterior region over 5 years].

Purpose: To evaluate the influence of crown-to-implant ratio (C/I ratio) on the results of restoration in the posterior region.

Methods: From January 2007 to January 2012,119 patients with 208 ITI implants in the posterior region were followed up for 6-66 months. Implant restorations were divided into three groups according to their respective clinical C/I ratios after noble porcelain-fused-to-mental crown restoration: C/I ≤1,1 View Article and Find Full Text PDF

[Implant-supported overdenture after pectoralis major myocutaneous flap reconstruction of tongue/floor of the mouth cancer:a case report].

Patients with oral cancer, undergoing ablative surgery, were left with severe deformities and dysfunction. Although the defect can be repaired by flap transplantation, there were still difficulties to restore normal oral structure and function of the oral cavity. In these instances, rehabilitation of mastication and occlusion is of the utmost importance.

[Effect of HA/TiO2 coating titanium surface on the growth of MG63].

Purpose: To evaluate the bioactivity of titanium surface treated by micro-arc oxidation (MAO) combined with ion beam assisted deposition (IBAD).

Methods: Titanium surfaces were treated by machined(S0), micro-arc oxidation(S1) and micro-arc oxidation combined with IBAD(S2), respectively. The topography and roughness of surfaces were determined by profilometer, and the bioactivity of the surface was evaluated by CLSM, MTT assay and ALP activity of cells.

[An experimental research of tissue engineered submandibular gland cells growing on collagen sponge scaffold].

Objective: To make an experimental research of the tissue engineered rat submandibular glands (SMG) cells growing on a collagen sponge scaffold under an optimal culture condition.

Methods: The Wistar rat (8 days old) SMG cells of the second generation were seeded on the surface of the collagen sponge scaffold (5 mm X 5 mm x 2 mm) and were cultured under a physiologically optimal condition for 3 weeks. At 1, 2 and 3 weeks, the cultured cells were observed on their shapes and structures by the histological examination and the scanning electron microscopy.

[The development and collagen ingredients analysis of submandibular gland acellular matrix].

Purpose: To develop submandibular gland acellular matrix and observe its structure and analyze its histological ingredients.

Methods: The fresh submandibular glands of SD mice were cell-extracted by chemical detergent and histological ingredients were analyzed by immunohistochemistry.

Results: Submandibular gland cells disappeared, matrix ingredients appeared network structure under microscopy.

[Effects of epidermal growth factor on calciumion and cAMP in the ductal cells of submandibular glands].

Purpose: To study the effects of EGF on Ca(2+) and cAMP in the ductal cells of rat SMG.

Methods: Fluorometric technique and radioimmunological technique were used to investigate the dynamic changes of Ca(2+) and cAMP in the ductal cells. The data were analysed statistically by t test.

[The development and ultrastructure study of acellular submandibular gland scaffold].

Purpose: To develop nature acellular submandibular gland scaffold materials and observe its ultrastructures.

Methods: The fresh submandibular glands of SD rats were cell-extracted by chemical detergent and observed with transmission and scanning electron microscope.

Results: Submandibular gland cells were dissolved and destroyed under transmission electron microscope.

[Restoration of deformities caused by complex fracture of the orbit region and adjacent cranio-maxillofacial fracture].

Objective: In order to improve the diagnosis and treatment of the complex fracture of the orbit region and adjacent cranio-maxillofacial fracture.

Methods: 73 cases with blowout fracture of the orbit and adjacent cranio-maxillofacial fracture in recent years were retrospectively analyzed and comparied with different methods of treatment. All cases had undertaken CT examinations.