MiR-27a-3p and miR-30b-5p inhibited-vitamin D receptor involved in the progression of tuberculosis.

Background: MicroRNAs (miRNAs) play a vital role in tuberculosis (TB). Vitamin D receptor (VDR), an miRNA target gene, and its ligand, vitamin D (VitD), have been reported to exert protective effects against TB. However, whether miRNAs can affect the progression of TB by targeting VDR has not been reported.

Case Report: Recurrence of Positive SARS-CoV-2 Results in Patients Recovered From COVID-19.

Coronavirus disease 2019 (COVID-19) is spreading throughout the world. Limited data are available for recurrence of positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in patients with long duration of COVID-19. We reported four cases recovered from COVID-19 with recurrence of positive SARS-CoV-2 results during the long-term follow-up.

[Application of BACs-on-Beads in prenatal diagnosis].

Objective: To explore the value of BACs-on-Beads (BoBs) for the practice of prenatal diagnosis.

Methods: The results of chromosomal karyotyping and BoBs of 1773 prenatal samples were compared. Microdeletions and microduplications detected by BoBs were subjected to chromosome microarray analysis (CMA) with informed consent from patients.