Publications by authors named "Chunduo Wang"
Article Synopsis
- Hepatitis B virus (HBV) infection is a significant global health issue, and current antiviral treatments face challenges, making targeting the HBx protein a potential solution for developing new therapies.
- A study utilized the Nano-Glo HiBiT Lysis Detection System to screen for herbal compounds that inhibit HBx, with asiatic acid from Centella asiatica showing promising results in reducing HBx levels and HBV activity in infected cells and mice.
- Findings suggest that asiatic acid works by promoting HBx degradation through autophagy, leading to decreased HBV transcription and establishing it as a potential anti-HBV treatment.
Persistent transcription of HBV covalently closed circular DNA (cccDNA) is critical for chronic HBV infection. Silencing cccDNA transcription through epigenetic mechanisms offers an effective strategy to control HBV. Long non-coding RNAs (lncRNAs), as important epigenetic regulators, have an unclear role in cccDNA transcription regulation.
View Article and Find Full Text PDFBackground: Progressive hepatitis B virus (HBV) infection can result in cirrhosis, hepatocellular cancer, and chronic hepatitis. While antiviral drugs that are now on the market are efficient in controlling HBV infection, finding a functional cure is still quite difficult. Identifying host factors involved in regulating the HBV life cycle will contribute to the development of new antiviral strategies.
View Article and Find Full Text PDFHydrogen sulfide (H S) is a redox gasotransmitter. It has been shown that H S has a key role in host antiviral defense by inhibiting interleukin production and S-sulfhydrating Keap1 lead to Nrf2/ARE pathway activation. However, it is yet unclear whether H S can play an antiviral role by regulating autophagy.
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