Publications by authors named "Chunchun Zou"
POU Class 2 Homeobox Associating Factor 1, as a Hub Candidate Gene in OP, Relieves Osteoblast Apoptosis.
Appl Biochem Biotechnol
September 2024
Increasing evidence suggests that osteoblast apoptosis contributes to the pathogenesis of postmenopausal osteoporosis (PMOP). This study aimed to identify a hub gene associated with osteoporosis (OP) progression and its functions. We utilized the GSE68303 expression dataset from GEO database and conducted weighted gene co-expression network analysis (WGCNA) to investigate changes in co-expressed genes between sham and ovariectomy (OVX) groups.
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- * In an ovariectomized mouse model of OP, EV treatment helped restore bone mass, reduced bone loss and cartilage damage, and promoted bone formation while inhibiting bone resorption.
- * The study identified that EVs increase the levels of USP7, which stabilizes YAP1 protein, and that this interaction plays a key role in activating the Wnt/β-catenin pathway, crucial for bone health.
Alteration of N6-methyladenosine (m6A) is closely linked to spanning biological processes including osteoporosis (OP) development. This research focuses on the function of methyltransferase like 14 (METTL14) in bone turnover and its interaction with T cell factor 1 (TCF1). A mouse model of OP was established by ovariectomy (OVX).
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