Publications by authors named "Chunchun Wei"

Article Synopsis
  • - The study introduces Ucp1-iCre knockin mice, designed to manipulate gene expression specifically in thermogenic adipose tissues, with minimal off-target effects compared to the conventional Ucp1-Cre line.
  • - Ucp1-iCre mice maintain normal thermogenesis and cold tolerance and show significant Cre activity in thermogenic adipose tissues, with minimal activity in other organs.
  • - Unlike Ucp1-iCre female mice, the male mice exhibit high rates of Cre-mediated recombination in germline cells, suggesting careful consideration is needed in breeding and genotyping.
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Aims: A myokine secreted by skeletal muscles during exercise called irisin mitigates ischemia-reperfusion (I/R) injury in epithelial cells of various organs by limiting damage to mitochondria. We test whether irisin may preserve the mitochondrial integrity and function in renal tubular epithelial cells and protect against ischemia-reperfusion-induced acute kidney injury (AKI).

Methods: We correlated serum irisin levels with serum creatinine and BUN levels from both AKI patients and healthy individuals.

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Background: Clear cell renal cell carcinoma (ccRCC) is characterized as one of the most common types of urological cancer with high degrees of malignancy and mortality. Due to the limited effectiveness of existing traditional therapeutic methods and poor prognosis, the treatment and therapy of advanced ccRCC patients remain challenging. Tryptophan metabolism has been widely investigated because it significantly participates in the malignant traits of multiple cancers.

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Background: Intracellular Ca cycling determines myocardial contraction and relaxation in response to physiological demands. SERCA2a (sarcoplasmic/endoplasmic reticulum Ca-ATPase 2a) is responsible for the sequestration of cytosolic Ca into intracellular stores during cardiac relaxation, and its activity is reversibly inhibited by PLN (phospholamban). However, the regulatory hierarchy of SERCA2a activity remains unclear.

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Arginase, a manganese (Mn)-dependent enzyme, is indispensable for urea generation and ammonia disposal in the liver. The potential role of fructose in Mn and ammonia metabolism is undefined. Here we demonstrate that fructose overconsumption impairs hepatic Mn homeostasis and ammonia disposal in male mice.

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Article Synopsis
  • Due to COVID-19, social distancing has reduced physical activity among older adults, increasing fall risks and health issues, making it vital to enhance their quality of life.
  • This study developed a smart somatosensory wearable assistive device (SSWAD) that uses electromyography and exergames to help older adults perform rehabilitation exercises at home while tracking their progress.
  • Results showed that the SSWAD was well-received, with a good usability score, especially among females with prior rehabilitation experience, suggesting it can boost motivation for ongoing home rehabilitation.
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Background: Clear cell renal cell carcinoma (ccRCC) is a common urinary cancer. Although diagnostic and therapeutic approaches for ccRCC have been improved, the survival outcomes of patients with advanced ccRCC remain unsatisfactory. Fatty acid metabolism (FAM) has been increasingly recognized as a critical modulator of cancer development.

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Very long-chain fatty acid elongase 3 (ELOVL3) catalyzes the synthesis of C20-C24 fatty acids and is highly expressed in the liver and adipose tissues. The deficiency of Elovl3 exhibits an anti-obesity effect in mice, but the specific role of hepatic ELOVL3 in lipid metabolism remains unclear. Here we demonstrate that hepatic Elovl3 is not required for lipid homeostasis or the pathogenesis of diet-induced obesity and hepatic steatosis.

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Unlabelled: Thyroid hormone (TH) has a profound effect on energy metabolism and systemic homeostasis. Adipose tissues are crucial for maintaining whole-body homeostasis; however, whether TH regulates systemic metabolic homeostasis through its action on adipose tissues is unclear. Here, we demonstrate that systemic administration of triiodothyronine (T3), the active form of TH, affects both inguinal white adipose tissue (iWAT) and whole-body metabolism.

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Brucellosis is a rare systemic zoonotic disease in kidney transplantation that affects graft survival. Only 7 cases have been reported to date. Herein, we report one case of brucellosis in a kidney transplant donor, which is different from previously reported recipient cases.

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Objectives: Brown adipose tissue (BAT) plays a critical role in energy expenditure by uncoupling protein 1 (UCP1)-mediated thermogenesis and represents an important therapeutic target for metabolic diseases. Carbohydrate response element-binding protein (ChREBP) is a key transcription factor regulating de novo lipogenesis, and its activity is associated with UCP1 expression and thermogenesis in BAT. However, the exact physiological role of endogenous ChREBP in BAT thermogenesis remains unclear.

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Background: Donor-derived human parvovirus B19 (B19V) infections are rarely reported. Thus, its incidence in kidney transplantation is still unknown due to lack of surveillance studies. Similarly, whether the donor needs to be routinely screened for B19V and whether the kidneys from those with B19V DNAemia could be accepted also remain unknown.

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Background And Aims: Lipoprotein lipase (LPL) is responsible for the lipolytic processing of triglyceride-rich lipoproteins, the deficiency of which causes severe hypertriglyceridemia. Liver LPL expression is high in suckling rodents but relatively low at adulthood. However, the regulatory mechanism and functional significance of liver LPL expression are incompletely understood.

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Article Synopsis
  • The study aimed to understand how daptomycin behaves in kidney transplant patients in China, focusing on the population pharmacokinetics (PPK) of the drug.
  • A mixed-effects model was used to analyze data from 49 patients, revealing that factors like glomerular filtration rate (GFR) and body weight significantly influence the drug's clearance and distribution.
  • The research established a dosing regimen for daptomycin based on GFR and weight, providing guidelines to personalize treatment and minimize toxicity for kidney transplant recipients.
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The zinc-finger protein ZBTB20 regulates development and metabolism in multiple systems, and is essential for postnatal survival in mice. However, its potential role in the cardiovascular system remains undefined. Here, we demonstrate that ZBTB20 is critically involved in the regulation of cardiac contractility and blood pressure in mice.

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Brown adipose tissue (BAT) plays a critical role in energy expenditure by uncoupling protein 1 (UCP1)-mediated thermogenesis. Carbohydrate response element-binding protein (ChREBP) is one of the key transcription factors regulating de novo lipogenesis (DNL). As a constitutively active form, ChREBP-β is expressed at extremely low levels.

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Excessive fructose consumption is closely linked to the pathogenesis of metabolic disease. Carbohydrate response element-binding protein (ChREBP) is a transcription factor essential for fructose tolerance in mice. However, the functional significance of liver ChREBP in fructose metabolism remains unclear.

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Background And Purpose: Tissue plasminogen activator (tPA) is the only approved pharmacological therapy for acute brain ischaemia; however, a major limitation of tPA is the haemorrhagic transformation that follows tPA treatment. Here, we determined whether nicotinamide mononucleotide (NMN), a key intermediate of nicotinamide adenine dinucleotide biosynthesis, affects tPA-induced haemorrhagic transformation.

Experimental Approach: Middle cerebral artery occlusion (MCAO) was achieved in CD1 mice by introducing a filament to the left MCA for 5 h.

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Article Synopsis
  • Scientists found that increasing a substance called NAD can help protect the brain from certain disorders, but it's not clear if it helps with brain bleeding conditions like intracerebral hemorrhage (ICH).
  • In their study with mice that had ICH, they gave a special treatment called NMN to see if it could help. While NMN didn't reduce blood clots, it did reduce brain swelling and death of brain cells.
  • The treatment also helped the mice recover better in terms of weight and brain function, suggesting that NMN can help protect the brain during injuries from ICH by reducing inflammation and stress in the brain.
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Background: Mycophenolic acid (MPA), a potent immunosuppressant, is widely used in solid organ transplantations. This study aimed to investigate the pharmacokinetics of enteric-coated mycophenolate sodium (EC-MPS) in Chinese adult renal allograft recipients and to generate optimal model equations for estimation of the MPA area under the concentration-time curve from 0 to 12 hours (AUC0-12 h), using a limited sampling strategy (LSS).

Methods: Serial blood samples were collected over 12 hours from 38 recipients of a primary living-related donor kidney graft treated with EC-MPS, tacrolimus, and corticosteroid.

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Article Synopsis
  • Designing highly reputable and successful products hinges on understanding consumer perceptions of product images, which influence their purchasing decisions.
  • The paper introduces a consumer-oriented design approach that employs various modeling techniques (like quantification theory type I, grey prediction, and neural networks) to find the best product form combinations that align with specific product images.
  • An experimental study using principles from Kansei Engineering shows that this approach effectively helps product designers, proving its utility beyond personal digital assistants to other consumer products.
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Synopsis of recent research by authors named "Chunchun Wei"

  • - Chunchun Wei's recent research spans diverse areas including thermogenic adipose tissue function, renal health, and cancer biology, focusing particularly on the mechanisms underlying various metabolic and pathological processes.
  • - Notable findings include the characterization of Ucp1-iCre knockin mice demonstrating specific recombination in male germ cells, and the protective role of irisin in renal tubular epithelial cells during acute kidney injury.
  • - Wei has also contributed to the understanding of metabolic pathways in clear cell renal carcinoma and the implications of fatty acid and tryptophan metabolism in cancer prognosis, highlighting their potential as therapeutic targets.