Publications by authors named "Chunchieh Wang"

This investigation explores the potential of co-incorporating nickel (Ni) and cobalt (Co) into copper oxide (CuO) nanostructures for bifunctional electrochemical charge storage and oxygen evolution reactions (OER). A facile wet chemical synthesis method is employed to co-incorporate Ni and Co into CuO, yielding diverse nanostructured morphologies, including rods, spheres, and flake. The X-ray diffraction (XRD) and Raman analyses confirmed the formation of NiCo-CuO nanostructure, with minor phases of nickel oxide (NiO) and cobalt tetraoxide (CoO).

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Background The growing population of male adolescent and young adult (AYA, 15-40 years old) cancer survivors has heightened interest in their reproductive health. However, studies have reported conflicting findings on the potential risks of cancer and its treatments on birth and obstetric outcomes. Methods We utilized encrypted identification numbers for both fathers and mothers to link three nationwide Taiwan datasets from 2004 to 2019, identifying 3,785 births with a paternal history of AYA cancer.

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Background: The effects of physical activity on the development of different types of cancers have not been comprehensively studied. This nationwide, population-based cohort study investigated the effects of leisure-time physical activity (LTPA) on the development of different types of cancer in Taiwanese adults. A total of 67,890 adult participants (≥ 18 y old) from five rounds (2001, 2005, 2009, 2013, and 2017) of the Taiwan National Health Interview Survey were included.

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  • The study investigated the prevalence of human papillomavirus (HPV) and its impact on prognosis in patients with vaginal cancer (VC) over a 31-year period.
  • Out of 79 VC patients, 98.6% of squamous cell carcinoma (SCC) and 83.3% of non-SCC cases tested positive for HPV, with HPV16 being the most common type.
  • Key findings revealed that advanced stages (III/IV) and lymph node metastasis were linked to worse survival rates, while positivity for p16 and HPV was associated with a better prognosis.
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  • Subclinical atrial fibrillation (AF) increases risks of developing clinical AF, stroke, and cardiovascular death; researchers aimed to test if closed loop stimulation (CLS) could reduce atrial high-rate episodes (AHREs) in pacemaker patients compared to conventional dual-chamber rate-adaptive pacing (DDDR).
  • A study with 1,210 patients showed that those using CLS had a lower incidence of the primary endpoint (first AHRE lasting ≥6 min, stroke, or TIA) compared to DDDR over a 3-year period, particularly effective in patients without atrioventricular block or AF history.
  • The findings suggest that dual-chamber CLS significantly reduces AHRE occurrence, highlighting its potential benefits for patients
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Addressing geogenic and anthropogenic arsenic (As) pollution is critical for environmental health. This study explored arsenite [As(III)] removal using Cyanidiales, particularly Cyanidium caldarium (Cc) and Galdieria partita (Gp), under acidic to neutral pH, and determined As(III) detoxification mechanisms in relation to As speciation and protein secondary structure in Cyanidiales. Regarding As(III) sorption amounts, Cc outperformed Gp, reaching 83.

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Purpose: Proton stereotactic radiosurgery (PSRS) has emerged as an innovative proton therapy modality aimed at achieving precise dose delivery with minimal impact on healthy tissues. This study explores the dosimetric outcomes of PSRS in comparison to traditional intensity-modulated proton therapy (IMPT) by focusing on cases with small target volumes. A custom-made aperture system designed for proton therapy, specifically tailored to small target volumes, was developed and implemented for this investigation.

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  • * The study involved six female cervical cancer patients, using hyperpolarized [1-C]-pyruvate MRI/MRS to analyze splenic metabolism before and after radiotherapy, aiming to assess tumor response.
  • * Results showed that responders had significantly lower baseline splenic HP [1-C]-lactate ratios compared to non-responders, and an increase in neutrophil counts post-treatment indicated heightened immune activity.
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  • Heart failure (HF) is a major global health issue, with similar death and rehospitalization rates across different types, but previous Taiwanese registries largely focused on hospitalized patients with HF reduced ejection fraction (HFrEF) before 2019, limiting their applicability to other types.
  • The Taiwan Society of Cardiology Heart Failure Registry 2020 aims to enroll 3,370 patients from 27 hospitals, including both inpatients with acute decompensated HF and outpatients who were hospitalized within the last six months, and will collect detailed health data over a two-year follow-up.
  • This registry is designed to provide insights into the epidemiology, guideline adherence, clinical outcomes, and disease progression for patients with all HF
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  • Heart failure with preserved ejection fraction (HFpEF) is a complex condition affecting the heart and other organs, leading to significant health issues, especially in younger patients in Asia with high rates of diabetes and kidney disease.
  • The diagnosis involves a 2-step algorithm focusing on symptoms, ejection fraction, natriuretic peptide levels, and tests for heart abnormalities; if uncertain, additional stress testing may be required.
  • Management includes controlling comorbidities, lifestyle changes like weight loss and exercise, and pharmacological treatments such as diuretics and SGLT2 inhibitors to improve patient outcomes.
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  • - The study analyzes the prescribing patterns and the effectiveness and safety of edoxaban in Asian patients with atrial fibrillation (AF) over one year, as part of the ETNA-AF program, which collects data from various Asian regions.
  • - Out of 3,359 patients treated with edoxaban, 70.9% received the recommended doses, and key clinical outcomes were measured, including rates of death, bleeding, and strokes at the one-year mark.
  • - The one-year event rates were relatively low, showing 1.8% for all-cause death and 1.3% for major bleeding, indicating that edoxaban is effective and safe for most Asian patients with AF in everyday practice
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Background: Concurrent chemoradiotherapy (CCRT) is the standard of care for locally advanced cervical cancer. In this study, we analyzed the pretreatment clinical and F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) characteristics of patients with locally advanced cervical squamous cell carcinoma (SCC) to develop a scoring prototype for risk stratification.

Methods: Two cohorts were constructed in this study.

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  • The study investigates how AI-enabled electrocardiography models can identify left atrial enlargement (LAE) using both P-wave analysis and single-lead ECGs in patients with sinus rhythm and non-sinus rhythm.
  • It analyzes data from over 382,000 patients, comparing the effectiveness of these AI models to traditional echocardiography in diagnosing LAE.
  • Results indicate that AI ECG models are better at predicting future cardiovascular diseases linked to severe LAE than echocardiography, with P-waves being crucial for accurate identification.
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Intelligent signal processing in unmanned stores enhances operational efficiency, notably through automated SKUs (Stock Keeping Units) recognition, which expedites customer checkout. Distinguishing itself from generic detection algorithms, the retail product detection algorithm addresses challenges like densely arranged items, varying scales, large quantities, and product similarities. To mitigate these challenges, firstly we propose a novel boundary regression neural network architecture, which enhances the detection of bounding box in dense arrangement, minimizing computational costs and parameter sizes.

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  • - This study focuses on developing a machine-learning model using standard 12-lead ECGs to identify patients at high risk of acute mortality in the emergency department (ED), as mortality rates are notably high among these patients.
  • - The model was created using data from over 345,000 ED patients and showed strong accuracy in predicting death within 30 days, with a high hazard ratio and an area under the ROC curve indicating excellent predictive ability across various causes of death.
  • - The findings suggest that the CNN-based ECG model can effectively act as a complementary tool alongside traditional methods for early warning of mortality risks, making it useful for improving patient care in the ED.
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  • Tubulin beta 4A (TUBB4A) spectrum disorders can cause conditions like dystonia type 4 and H-ABC syndrome, but sometimes only lead to mild hypomyelination.
  • A family case with a TUBB4A mutation presented complicated hereditary spastic paraplegia (HSP), prompting whole-exome sequencing to find the cause of their symptoms.
  • Researchers identified a novel TUBB4A mutation in affected family members, which was linked to adult-onset spastic paraparesis and brain hypomyelination, while cognitive abilities remained intact.
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Edoxaban, a once-daily, direct-acting oral anticoagulant, is approved to prevent stroke or systemic embolism in non-valvular atrial fibrillation (NVAF) and treat venous thromboembolism. The clinical benefit of edoxaban for stroke prevention in Asian patients with NVAF has been demonstrated in clinical and real-world studies. We share early clinical experiences with once-daily edoxaban and discuss its evidence-based use in patients with NVAF in Southeast Asia through several cases of patients at high risk, including frail patients, elderly patients with multiple comorbidities and patients with increased bleeding risk.

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  • Brain metastasis often occurs in patients with non-small cell lung cancer (NSCLC), and some need neurosurgery for treatment, followed by systemic therapy.
  • A study analyzed 93 NSCLC patients between 2017 and 2021, revealing a median postresection survival of 34.36 months, with better outcomes for those with adenocarcinoma compared to non-adenocarcinoma types.
  • Factors like poor performance status (ECOG PS ≥2) and liver metastasis were linked to lower survival rates, highlighting the importance of these factors in treatment decisions.
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  • This study investigates the best management strategies for elderly patients (aged 80+) with non-small cell lung cancer (NSCLC) in Taiwan, examining treatment options and mortality risks.
  • Researchers analyzed data from the Taiwan Cancer Registry for patients diagnosed between 2010 and 2017, focusing on the impact of curative, palliative, and no treatment on survival outcomes.
  • Results indicated that elderly patients receiving either palliative or curative treatments experienced significantly lower mortality risks compared to those who did not receive any treatment, highlighting the need for further research on their complications and quality of life.
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  • Cardiac amyloidosis is a type of systemic amyloidosis where abnormal amyloid fibrils accumulate in heart tissue, leading to heart failure due to restrictive cardiomyopathy and conduction problems.
  • The condition is more common than previously thought, especially in certain populations, but is often diagnosed late, indicating a need for better awareness and collaboration among healthcare professionals.
  • The Taiwan Society of Cardiology has created an "Expert Consensus" to enhance the diagnosis and treatment of cardiac amyloidosis, introducing helpful tools and algorithms to aid in early detection and care for patients, including acronyms for diagnosing transthyretin amyloid cardiomyopathy.
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The 3-D matrix scale ion-exchange mechanism was explored for high-capacity cadmium (Cd) removal using bone chars (BC) chunks (1-2 mm) made at 500 °C (500BC) and 700 °C (700BC) in aqueous solutions. The Cd incorporation into the carbonated hydroxyapatite (CHAp) mineral of BC was examined using a set of synchrotron-based techniques. The Cd removal from solution and incorporation into mineral lattice were higher in 500BC than 700BC, and the diffusion depth was modulated by the initial Cd concentration and charring temperature.

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Background: Cancer treatment in female adolescent and young adult (AYA) cancer survivors (i.e., those diagnosed between 15 and 39 years of age) may adversely affect multiple bodily functions, including the reproductive system.

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The prevalence of heart failure is increasing, causing a tremendous burden on health care systems around the world. Although mortality rate of heart failure has been significantly reduced by several effective agents in the past 3 decades, yet it remains high in observational studies. More recently, several new classes of drugs emerged with significant efficacy in reducing mortality and hospitalization in chronic heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF).

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Although it is commonly considered that, in birds, there is a trend towards reduced dentition, teeth persisted in birds for 90 Ma and numerous macroscopic morphologies are observed. However, the extent to which the microstructure of bird teeth differs from other lineages is poorly understood. To explore the microstructural differences of the teeth of birds in comparison with closely related non-avialan dinosaurs, the enamel and dentine-related features were evaluated in four Mesozoic paravian species from the Yanliao and Jehol biotas.

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