Polymyxin B and fusidic acid, a novel potent synergistic combination against and isolates with polymyxin B resistance.

The increasing prevalence of multidrug-resistant (MDR) Gram-negative bacteria and comparatively limited options of antibiotics pose a major threat to public health worldwide. Polymyxin B is the last resort against extensively resistant Gram-negative bacterial infections. However, a large number of Gram-negative bacteria exhibited high-level resistance to Polymyxin B, bringing challenges for antimicrobial chemotherapy.

A novel small-molecule compound S-342-3 effectively inhibits the biofilm formation of .

Biofilms are an important virulence factor in and are characterized by a structured microbial community consisting of bacterial cells and a secreted extracellular polymeric matrix. Inhibition of biofilm formation is an effective measure to control infection. Here, we have synthesized a small molecule compound S-342-3, which exhibits potent inhibition of biofilm formation in both MRSA and MSSA.

Molecular Characteristics and Gonococcal Genetic Island Carrying Status of Thirty-Seven Isolates in Eastern China.

Purpose: To investigate the carrying situation of genetic island (GGI), and to understand the existence of GGI of different multilocus sequence types (MLST), so as to provide evidence for epidemiology.

Methods: From January 2018 to December 2020, a total of 37 clinical isolates of were collected. Resistance to tetracycline, β-lactam, and azithromycin were measured.

The Dissemination of Fusidic Acid Resistance Among Clinical Isolates in Wenzhou, China.

Purpose: Fusidic acid (FA), a potent steroidal antibiotic, is used topically to treat skin and soft tissue infections (SSTIs) caused by . The aim of this study is to report the prevalence of fusidic acid resistance among clinical isolates from a tertiary hospital in Wenzhou, east China.

Methods: The antibiotic susceptibility of isolates was determined by disc diffusion method and agar dilution method.

Antimicrobial Resistance And Molecular Characteristics Among Clinical Isolates In A Chinese Tertiary Hospital.

Purpose: The resistance of to antimicrobial agents has been increasing year by year due to the overuse of antibiotics. The primary aims of the present study were to investigate the molecular characteristics of the clinical isolates of and the resistance to azithromycin in a Chinese tertiary hospital.

Methods: From January 2014 to May 2017, a total of 55 clinical isolates of were collected.

Low prevalence of mupirocin resistance among Staphylococcus aureus clinical isolates from a Chinese tertiary hospital.

Between September 2013 and March 2016, 26 (1.95 %) of 1333 Staphylococcus aureus clinical isolates from a Chinese hospital were found to be resistant to mupirocin, including 18 (1.35 %) with high-level mupirocin resistance and 8 (0.