Associations between ethylene oxide exposure and biological age acceleration: evidence from NHANES 2013-2016.

Introduction: Population aging is a global concern, with the World Health Organization predicting that by 2030, one in six individuals worldwide will be 60 years or older. Ethylene oxide (EO) is a widely used industrial chemical with potential health risks, including associations with age-related diseases. This study investigates the relationship between EO exposure and biological age acceleration.

Associations between dietary carotenoid and biological age acceleration: insights from NHANES 2009-2018.

Carotenoids are naturally occurring pigments found in plants and certain microorganisms. Some carotenoids act as precursors to vitamin A, which is essential for various health aspects, including vision, immune function, and skin health. Carotenoids, including α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein and zeaxanthin, are known to reduce the risk of age-related diseases and promote healthy aging.

Bioinformatic analysis of hippocampal histopathology in Alzheimer's disease and the therapeutic effects of active components of traditional Chinese medicine.

Background And Aim: Pathological changes in the central nervous system (CNS) begin before the clinical symptoms of Alzheimer's Disease (AD) manifest, with the hippocampus being one of the first affected structures. Current treatments fail to alter AD progression. Traditional Chinese medicine (TCM) has shown potential in improving AD pathology through multi-target mechanisms.

Frontiers and hotspots evolution in mild cognitive impairment: a bibliometric analysis of from 2013 to 2023.

Background: Mild cognitive impairment is a heterogeneous syndrome. The heterogeneity of the syndrome and the absence of consensus limited the advancement of MCI. The purpose of our research is to create a visual framework of the last decade, highlight the hotspots of current research, and forecast the most fruitful avenues for future MCI research.

No genetic link between Parkinson's disease and SARS-CoV-2 infection: a two-sample Mendelian randomization study.

Objective: Existing literature has not clearly elucidated whether SARS-CoV-2 infection increases the incidence of Parkinson's disease or if Parkinson's disease patients are more susceptible to the effects of SARS-CoV-2 infection. To clarify the issue, this study employs a genetic epidemiological approach to investigate the association.

Methods: This study utilizes a two-sample Mendelian randomization analysis.

Conductometric Gas Sensor Based on MoO Nanoribbon Modified with rGO Nanosheets for Ethylenediamine Detection at Room Temperature.

An ethylenediamine (EDA) gas sensor based on a composite of MoO nanoribbon and reduced graphene oxide (rGO) was fabricated in this work. MoO nanoribbon/rGO composites were synthesized using a hydrothermal process. The crystal structure, morphology, and elemental composition of MoO/rGO were analyzed via XRD, FT-IR, Raman, TEM, SEM, XPS, and EPR characterization.

Colony‑stimulating factor CSF2 mediates the phenotypic plasticity of small‑cell lung cancer by regulating the p‑STAT3/MYC pathway.

Relapse and drug resistance are the main causes of mortality in patients with small‑cell lung cancer (SCLC). Intratumoral heterogeneity (ITH) is a key biological mechanism that leads to relapse and drug resistance. Phenotypic plasticity is an important factor that leads to ITH in SCLC, although its mechanisms and key regulatory factors remain to be elucidated.

Relationship between Classification of Fabellae and the Severity of Knee Osteoarthritis: A Relevant Study in the Chinese Population.

Objective: To classify the fabellae and discuss the relationship between the classification of fabellae and the severity of knee osteoarthritis (KOA) in Chinese.

Methods: From February 2019 to February 2020, 136 patients were measured and classified using three-dimensional computed tomography (CT) reconstruction. According to the CT imaging characteristics, the fabellae were divided into five types: type I, a fabella on the lateral femoral condyle; type II, a fabella on the medial femoral condyle; type III, a fabella on the lateral femoral condyle and a fabella on the medial femoral condyle; type IV, two fabellae on the medial femoral condyle; and type V, two fabellae on the lateral femoral condyle.

Generalized Synthesis of Ultrathin Cobalt-Based Nanosheets from Metallophthalocyanine-Modulated Self-Assemblies for Complementary Water Electrolysis.

The development of effective approaches for preparing large-area, self-standing, ultrathin metal-based nanosheets, which have proved to be favorable for catalytic applications such as water electrolysis, is highly desirable but remains a great challenge. Reported herein is a simple and versatile strategy to synthesize ultrathin Co O and CoP NSs consisting of close-packed nanoparticles by pyrolyzing cobalt(II) phthalocyanine/graphene oxide (CoPc/GO) assemblies in air and subsequent topotactic phosphidation while preserving the graphene-like morphology. The strong π-π stacking interactions between CoPc and GO, and the inhibiting effect of the tetrapyrrole-derived macrocycle for grain growth during the catalytic carbon gasification contribute to the NSs forming.

Ethylenediamine-modified graphene oxide covalently functionalized with a tetracarboxylic Zn(ii) phthalocyanine hybrid for enhanced nonlinear optical properties.

Tetracarboxylic Zn(ii) phthalocyanine-amino functionalized graphene oxide (ZnPcC4-NGO) hybrid materials have been prepared by a covalent functionalization method. The characterizations indicate that the amino-functionalization of GO has an important influence on the structure and photophysical properties of the ZnPcC4-NGO hybrid. The ZnPcC4-NGO hybrid exhibits enhanced photo-induced electron transfer or energy transfer (PET/ET), compared to the ZnPcC4 covalent functionalized GO (ZnPcC4-GO), owing to the presence of the extended sp(2) carbon configurations, along with the partial reduction of the NGO nanosheets and the introduction of electron-donating ethylenediamine.

An electrochemical bifunctional sensor for the detection of nitrite and hydrogen peroxide based on layer-by-layer multilayer films of cationic phthalocyanine cobalt(ii) and carbon nanotubes.

As vital biological mediators, the accurate detection of nitrite (NO ) and hydrogen peroxide (HO) is desirable for clinical monitoring and diagnosis. Herein, cationic 2,9,16,23-tetra[4-(N-methyl)pyridinyloxy]phthalocyanine cobalt(ii) ([TMPyPcCo]) and acid-treated multiwalled carbon nanotubes (aCNTs) were alternately self-assembled on the glassy carbon electrode (GCE) by means of the electrostatic interaction, leading to a 3D loose and interconnected assembly of [TMPyPcCo/aCNTs] multilayer films. In the [TMPyPcCo/aCNTs] films, [TMPyPcCo] is anchored onto the surface of aCNTs without any inert polymer binders, which is beneficial to expose more active sites for electrocatalysis.

Enhanced NH3-Sensitivity of Reduced Graphene Oxide Modified by Tetra-α-Iso-Pentyloxymetallophthalocyanine Derivatives.

Three kinds of novel hybrid materials were prepared by noncovalent functionalized reduced graphene oxide (rGO) with tetra-α-iso-pentyloxyphthalocyanine copper (CuPc), tetra-α-iso-pentyloxyphthalocyanine nickel (NiPc) and tetra-α-iso-pentyloxyphthalocyanine lead (PbPc) and characterized by Fourier transform infrared spectroscopy (FT-IR), ultraviolet-visible spectroscopy (UV-vis), Raman spectra, X-ray photoelectron spectroscopy (XPS), transmission electron microscope (TEM), and atomic force microscope (AFM). The as-synthesized MPc/rGO hybrids show excellent NH3 gas-sensing performance with high response value and fast recovery time compared with bare rGO. The enhancement of the sensing response is mainly attributed to the synergism of gas adsorption of MPc to NH3 gas and conducting network of rGO with greater electron transfer efficiency.

The effects of central metals on the photophysical and nonlinear optical properties of reduced graphene oxide-metal(II) phthalocyanine hybrids.

Reduced graphene oxide-metal(II) phthalocyanine (RGO-MPc, M = Cu, Zn and Pb) hybrid materials have been prepared by the covalent functionalization method. The resultant RGO-MPc hybrids are characterized by scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared, ultraviolet-visible absorption and fluorescence spectroscopy. The RGO-MPc hybrids exhibit strong fluorescence quenching by means of the photo-induced electron transfer or the energy transfer (PET/ET) process between the RGO and MPc moieties.

A multiwalled carbon nanotube/tetra-β-isoheptyloxyphthalocyanine cobalt(ii) composite with high dispersibility for electrochemical detection of ascorbic acid.

A sensitive electrochemical sensor for ascorbic acid (AA) is designed and synthesized via the following steps. The novel tetra-β-isoheptyloxyphthalocyanine cobalt(ii) (PcCo) spontaneously adsorbs on the surface of acid-treated multi-walled carbon nanotubes (aMWCNTs). Then, the aMWCNT/PcCo composite was immobilized on the glassy carbon electrode (GCE).

Ultrafast third-order nonlinear optical properties of ZnPc(OBu)(6)(NCS)/DMSO solution.

The ultrafast third-order nonlinear optical properties of ZnPc(OBu)(6)(NCS)/dimethyl sulfoxide solution are investigated by optical Kerr effect (OKE) and pump-probe techniques with femtosecond pulses. Using CS(2) as the reference, the third-order susceptibility of the sample solution is obtained as about 1.40x10(-14) esu at a concentration of 3.

[Synthesis and spectra of novel metal complexes of multi-nitrogen heterocyclic ligand].

Novel multi-nitrogen heterocyclic metal complexes M(HMPB)2 (M = Co, Ni) using 2-(2'-hydroxy-5'-methyl phenyl) benzotriazole (HMPB) as ligand, were synthesized by the methanol aqueous solution precipitation method for the first time. The as-prepared samples were characterized by element analysis and laser-desorption ionization time-of-flight mass spectrometry (LDI-TOF-MS). The Fourier transform infrared characteristic spectra (FTIR) and ultraviolet visible electronic absorption spectrum (UV-Vis) of the new complexes were also studied especially.

[Spectral study of monoisothiocyanato-substituted 3:1 asymmetrical phthalocyanine zinc(II)].

Electronic absorption spectra of three monoisothiocyanato-substituted asymmetrical phthalocyanine zinc(II), 2-isothiocyanato-9,10,16,17,23,24-alkyloxyphthalocyanine zinc(II) [(RO)6 (NCS)PcZn(II)] (R = n-C4H9, n-C5H11, n-C10H21), were measured in five organic solvents. The effect and order of the substitute groups and solvents were studied by electronic absorption spectra. The changes of lamda(max) data are very small between monoamino- and monoisothiocyanato-substituted asymmetrical phthalocyanines.