Associations between cancer-related coping and depressive symptoms in oral cancer patients.

Objectives: Specific coping styles have been found to influence several aspects of psychological health in various ways among cancer patients. Therefore, the aim of the current study was to examine whether different coping styles are associated with depressive symptoms in oral cancer patients.

Methods: The current cross-sectional study was conducted from May 2021 to October 2022 in Liaoning Province, China.

Mediating effect of social constraints in the association between stigma and depressive symptoms in Chinese breast cancer patients.

Purpose: The present study aimed to investigate the effect of stigma on depressive symptoms and explore the mediating role of social constraints between stigma and depressive symptoms in Chinese breast cancer (BC) patients.

Methods: A cross-sectional design was conducted in China from December 2020 to July 2021. Out of 256 participants, 222 BC patients completed the questionnaires composed of demographic and clinical information, Patient Health Questionnaire-9 (PHQ-9), Social Impact Scale (SIS), and 15-item Social Constraints Scale (SCS-15).

Virus-Mimetic Extracellular-Vesicle Vaccine Boosts Systemic and Mucosal Immunity via Immune Recruitment.

Mucosal vaccines can prevent viruses from infecting the respiratory mucosa, rather than only curtailing infection and protecting against the development of disease symptoms. The SARS-CoV-2 spike receptor-binding domain (RBD) is a compelling vaccine target but is undermined by suboptimal mucosal immunogenicity. Here, we report a SARS-CoV-2-mimetic extracellular-vesicle vaccine developed using genetic engineering and dendritic cell membrane budding.

Immunogenicity and safety of a self-assembling ZIKV nanoparticle vaccine in mice.

Zika virus (ZIKV) is a mosquito-borne flavivirus that highly susceptibly causes Guillain-Barré syndrome and microcephaly in newborns. Vaccination is one of the most effective measures for preventing infectious diseases. However, there is currently no approved vaccine to prevent ZIKV infection.

Role of social support in the relationship between resilience and sleep quality among cancer patients.

Introduction: The present study aimed to investigate the effect of resilience on sleep quality and explore the role of social support between resilience and sleep quality in cancer patients.

Methods: A multicenter and cross-sectional study was conducted in China from May to November 2021. A total of 202 cancer patients were recruited to complete the questionnaires composed of demographic information, Pittsburg Sleep Quality Index (PSQI), Resilience Scale-14 (RS-14), and Multidimensions Scale of Perceived Social Support (MSPSS).

Effects of physical and psychological symptoms on cancer-related fatigue among esophageal cancer patients.

Background: Cancer-related fatigue (CRF) is considered one of the most prevalent and distressing symptoms among cancer patients and may vary among patients with different cancer types. However, few studies have explored the influence of physical and psychological symptoms on CRF among esophageal cancer (EC) patients without esophagectomy. Therefore, this study aimed to examine the effects of physical and psychological symptoms on CRF among EC patients without esophagectomy.

Multifunctional liposomes Co-encapsulating epigallocatechin-3-gallate (EGCG) and miRNA for atherosclerosis lesion elimination.

Atherosclerosis (AS) is a chronic inflammatory disease, characterized by a lipid accumulated plaque. Anti-oxidative and anti-inflammation and lipid metabolism promoting therapeutic strategies have been applied for atherosclerosis treatment. However, the therapeutic effect of a single therapeutic method is limited.

Association between Serum Amyloid A Levels and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Backgruound: To date, consistent data have not been reported on the association between serum amyloid A (SAA) levels and type 2 diabetes mellitus (T2DM). The purpose of this study was to systematically summarize their relationship.

Methods: Databases including PubMed, Cochrane Library, Embase, Web of Science, and MEDLINE were searched until August 2021.

The Environment-Economy Synergistic Improvement Effect of the "Two-Oriented Society" Pilot Area in China.

The establishment of the "two-oriented society" pilot zone is China's effort to explore an economic-environmental synergistic growth approach, and it is an important basis on which to solve the dilemma between economic development and environmental protection in less developed countries. By constructing an inter-provincial panel dataset and taking the "two-oriented society" pilot area as a policy intervention event, a quasi-natural experiment was conducted to evaluate the observed differences in economic growth and pollutant emissions using counterfactual estimation. The results show that, during the policy intervention period, the emission of solid waste in Hubei and Hunan provinces was significantly reduced, and the level of haze particles in Hunan province was also remarkably suppressed; however, the environmental emission problems such as water pollution were not improved in comparison to the national level.

Profiles of social constraints and associated factors among breast cancer patients: a latent profile analysis.

Background: The present study aimed to identify profiles of social constraints among Chinese breast cancer patients and to explore the variables associated with these patterns.

Methods: The study recruited 133 Chinese breast cancer patients in Liaoning Province, China, between June 2021 and February 2022. The questionnaire package included the Social Constraints Scale (SCS), the Multidimensional Scale of Perceived Social Support (MSPSS), the Fear of Progression Questionnaire-Short Form (FoP-Q-SF), and the Social Impact Scale (SIS).

Corrigendum: Association of single-nucleotide polymorphisms of rs2383206, rs2383207, and rs10757278 with stroke risk in the Chinese population: A meta-analysis.

[This corrects the article DOI: 10.3389/fgene.2022.

Design Strategies for and Stability of mRNA-Lipid Nanoparticle COVID-19 Vaccines.

Messenger RNA (mRNA) vaccines have shown great preventive potential in response to the novel coronavirus (COVID-19) pandemic. The lipid nanoparticle (LNP), as a non-viral vector with good safety and potency factors, is applied to mRNA delivery in the clinic. Among the recently FDA-approved SARS-CoV-2 mRNA vaccines, lipid-based nanoparticles have been shown to be well-suited to antigen presentation and enhanced immune stimulation to elicit potent humoral and cellular immune responses.

Empirical analysis of the role of the environmental accountability system in energy conservation and emission reduction in China.

Many developing countries are facing the difficulty of choosing between economic growth and energy conservation and emission reduction (ECER). China has strengthened the implementation of ECER by setting environmental accountability as the development goal of local governments, hoping to have better governance effects. To evaluate the actual intervention effect of this approach, this paper constructs panel data covering 46 countries from 1995 to 2014 and uses the difference-in-differences (DID) method and the composite control method to quantitatively analyse the policy effect.

Association of Single-Nucleotide Polymorphisms of rs2383206, rs2383207, and rs10757278 With Stroke Risk in the Chinese Population: A Meta-analysis.

Several studies have reported that chromosome 9p21 is significantly associated with ischemic stroke (IS) risk, with the G allele associated with increased risk. However, controversial results have been reported in the literature. We systematically assessed the relationship between stroke and three 9p21 loci (rs2303206, rs2383207, and rs10757278) in this meta-analysis.

Effectiveness of thalidomide for ankylosing spondylitis: a meta-analysis of randomized controlled trials in China.

Several studies have demonstrated the benefits of thalidomide as a treatment for patients with ankylosing spondylitis (AS); however, published literature reported controversial results. We conducted a meta-analysis to systematically evaluate the efficacy of thalidomide in AS patients. PubMed, Embase, Cochrane Library, Web of Science, Wanfang Data, and China National Knowledge Infrastructure (CNKI) were searched for relevant studies.

Impacts of the West-East Gas Pipeline Project on energy conservation and emission reduction: empirical evidence from Hubei province in Central China.

The extensive use of natural gas provides a new approach to low carbonization of the structure of primary energy sources, as well as reduces the peak in carbon emissions before fossil fuels are completely replaced by clean energy. To explore the impact of the West-East Gas Pipeline Project (WEGPP) on energy conservation and emission reduction in Chinese inland areas, the effects of policy intervention on the socio-economic development in Hubei province are preliminary investigated in this paper. The causal inference of multi-bandwidth and multi-core analysis is carried out using regression discontinuity design (RDD), and the core conclusion of the counterfactual analysis is proven to be robust based on the synthetic control method.

Anti-EpCAM functionalized graphene oxide vector for tumor targeted siRNA delivery and cancer therapy.

Graphene oxide (GO) has emerged as a potential drug delivery vector. For siRNA delivery, GO should be modified to endow it with gene delivery ability and targeting effect. However, the cationic materials used previously usually had greater toxicity.

Cetuximab-Modified Human Serum Albumin Nanoparticles Co-Loaded with Doxorubicin and MDR1 siRNA for the Treatment of Drug-Resistant Breast Tumors.

Background: Breast cancer is the most prevalent cancer among women. Doxorubicin (DOX) is a common chemotherapeutic drug used to treat many different cancers. However, multidrug resistance limits the treatment of breast cancer.

Health-related quality of life and social constraints among Chinese breast cancer patients: a cross-sectional study.

Background: Most research studying social constraints has been performed among Caucasian or Asian American breast cancer (BC) patients, but few studies have evaluated social constraint levels and explored the effect of social constraints on the integrative health-related quality of life (HRQOL) of Chinese BC patients. Therefore, our study aimed to examine the association of social constraints with HRQOL among Chinese women with BC.

Methods: This was a cross-sectional study of 136 Chinese women diagnosed with BC in Liaoning Province, China, from December 2020 to May 2021.

Effects of Self-Esteem on the Associations Between Infertility-Related Stress and Psychological Distress Among Infertile Chinese Women: A Cross-Sectional Study.

Background: Anxiety and depression are the most common psychological causes of distress in infertile women. Our study aimed to evaluate the prevalence of depression and anxiety and investigate the effects of self-esteem on the association of infertility-related stress with depression and anxiety among infertile women.

Methods: This study was conducted between December 2017 and May 2018.

Migration of manufacturing industries and transfer of carbon emissions embodied in trade: empirical evidence from China and Thailand.

At present, China's carbon emissions rank first in the world, which not only brings huge challenges to the sustainable development of China's economy, but also brings more pressure from public opinion in the international community. With the outward migration of China's manufacturing industries to Southeast Asia, the carbon emissions embodied in trade has also been transferred. These trends provide a good opportunity to analyze the characteristics of transnational industrial restructuring and spatial structure transformation of carbon emissions between China and Southeast Asian countries.

Preparation Optimization of Bovine Serum Albumin Nanoparticles and Its Application for siRNA Delivery.

Background: siRNA brings hope for cancer therapy. However, there are many obstacles for application of siRNA in clinical. Because of the excellent biocompatibility, non-toxicity and non-immunogenicity of bovine serum albumin (BSA), BSA-based nanoparticles have been widely designed as a drug carrier system.