Correlation between serum high-density lipoprotein cholesterol and bone mineral density in vitamin D-deficient populations.

Introduction: To investigate the relationship between serum high-density lipoprotein (HDL) cholesterol and bone mineral density (BMD) in vitamin D-deficient population.

Materials And Methods: This study was a cross-sectional study. From January to December 2020, 2583 middle-aged and older adult aged 40 and above were randomly selected in the Health Management Center of the Affiliated Hospital of Guizhou Medical University for health examination and questionnaire survey.

Genetic Underpinnings of Oligoasthenoteratozoospermia.

Oligoasthenoteratozoospermia (OAT) is a frequent but severe type of male infertility. As one of the most multifaceted male infertility resulting from sperm problems, its genetic etiology remains unknown in most cases. In this review, we systematically sort out the latest literature on clinical reports and animal models leading to OAT, summarise the expression profiles of causative genes for OAT, and highlight the important role of the protein transport system during spermiogenesis, spermatid cell-specific genes, Golgi and acrosome-related genes, manchette-related genes, HTCA-related genes, and axoneme-related genes in OAT development.

High-Performance Quantum Dot Near-Infrared Upconversion Devices Based on the Hole-Only Injection Mechanidsm.

Colloidal quantum dot (CQD) near-infrared (NIR) upconversion devices (UCDs) can directly convert low-energy NIR light into higher energy visible light without the need for additional integrated circuits, which is advantageous for NIR sensing and imaging. However, the state-of-the-art CQD NIR upconverters still face challenges, including high turn-on voltage (), low photon-to-photon (p-p) upconversion efficiency, and low current on/off ratio, primarily due to inherent limitations in the device structure and operating mechanisms. In this work, we developed a CQD NIR UCD based on a hole-only injection mechanism.

Efficient electrochemiluminescence sensor utilizing Zr-PyTCPPMOF for swift hydrogen sulfide detection.

The ultrahigh-sensitive detection of HS is reported using a novel dual-ligand metal-organic framework (MOF) electrochemiluminescence (ECL) sensor. By combining tetrakis(4-carboxyphenyl) porphyrin (TCPP) and 1,3,6,8-tetrakis(4-carboxyphenyl) pyrene (TBAPy) as ligands and employing zirconium as the metal source, a spindle-shaped Zr-PyTCPPMOF was successfully designed and synthesized. Notably, the multiple nitrogen structures of porphyrin provided abundant binding sites for sulfur (S), further enhancing the ECL signal of Zr-PyTCPPMOF.

AYVM to AYMM transition on HER2 exon 20 insertion induces TKI resistance in NSCLC.

Pyrotinib, a novel pan-HER tyrosine kinase inhibitor, has demonstrated substantial anti-tumor activity in non-small cell lung cancer (NSCLC) patients harboring HER2 mutations. However, the inevitable resistance to pyrotinib necessitates an in-depth understanding of the underlying mechanisms. In this study, potential resistance-associated mutations were identified through genomic sequencing of clinically paired samples and were validated using in vitro and in vivo models.

Iodine as Polarity-Reversal Catalyst: Synthesis of a Fused Heterocycle with Contiguous Stereocenters.

We report an unconventional I-catalyzed cascade reaction for the synthesis of angular triquinane derivatives with a fused heterocycle skeleton, leveraging enaminones and anilines as simple acyclic precursors. The key to success lies in I functioning as a polar-reversal catalyst, which alters the reactivity at the α-position of the enaminone and facilitates the first hexa-functionalization of an enaminone along with the formation of highly congested continuous stereocenters.

Multi-omic profiling highlights factors associated with resistance to immuno-chemotherapy in non-small-cell lung cancer.

Although immune checkpoint blockade (ICB) therapies have shifted the treatment paradigm for non-small-cell lung cancer (NSCLC), many patients remain resistant. Here we characterize the tumor cell states and spatial cellular compositions of the NSCLC tumor microenvironment (TME) by analyzing single-cell transcriptomes of 232,080 cells and spatially resolved transcriptomes of tumors from 19 patients before and after ICB-chemotherapy. We find that tumor cells and secreted phosphoprotein 1-positive macrophages interact with collagen type XI alpha 1 chain-positive cancer-associated fibroblasts to stimulate the deposition and entanglement of collagen fibers at tumor boundaries, obstructing T cell infiltration and leading to poor prognosis.

Porcine ISG15 fused IFN-λ3 as a novel antiviral agent for treating porcine reproductive and respiratory syndrome virus infection in vivo.

IFN-λs hold promise as therapeutic candidates against mutable respiratory viruses, but their efficacy against porcine reproductive and respiratory syndrome virus (PRRSV) remains unclear. In this study, we expressed a recombinant fusion protein consisting of porcine ISG15 linked porcine IFN-λ3 (ISG15-IFN-λ3) via a rigid protein linker in Escherichia coli (E. coli).

Primary Extraosseous Ewing Sarcoma on 18 F-FDG and 68 Ga-FAPI-04 PET/CT.

Primary extraosseous Ewing sarcoma of the nasal cavity is rare. A 17-year-old man underwent 18 F-FDG and 68 Ga-FAPI-04 PET/CT for a nasal mass. The mass showed avid FDG uptake but weak FAPI uptake.

Diversity and role of volatile terpene and terpenoid pheromones in insects.

Insect pheromones are critical chemical signals that regulate intraspecific behavior and play a key role in the dynamic monitoring and control of pest populations. Historically, research on insect pheromones has primarily focused on lipid-based compounds. However, terpenes and terpenoids, which are widely occurring classes of bioactive compounds, also play significant roles in insect pheromone blends.

Enhancing genomic association studies in slash pine through close-range UAV-based morphological phenotyping.

In forestry genetics and industry, tree morphological traits such as height, crown size, and shape are critical for understanding growth dynamics and productivity. Traditional methods for measuring these traits are limited in efficiency, scalability, and accuracy, posing challenges for large-scale forest assessments. This study focuses on integrating unmanned aerial vehicle (UAV) technology with GWAS to improve genomic association studies in slash pine ().

Intramolecular/Intermolecular Sequential Cyclization Accompanied by Double C-F Bond Cleavage: Access to Tricyclic Fluorine-Containing Pyrano[3,2-]chromenes.

Defluorinative cyclization of CF-alkenes has emerged as a reliable strategy for crafting intricate polycyclic frameworks. In this study, a facile defluorinative bicyclization approach was developed for the construction of 4,5-pyrano[3,2-]chromenes under mild conditions involving a sequence of intramolecular cyclization and intermolecular defluoroheterocyclization. A variety of polysubstituted 4,5-pyrano[3,2-]chromenes featuring C2-fluorine could be synthesized in good yields with excellent tolerance toward various functional groups.

Synthesis of 6--Spiro[4.5]decane Derivatives by Merging Ring-Opening of Benzo[]oxepines and Formal 1,2-Oxygen Migration.

A facile one-pot synthetic method has been developed for constructing 6--spiro[4.5]decane skeletons by merging the ring-opening of benzo[]oxepines and formal 1,2-oxygen migration reactions. More than 30 examples of the 6--spiro[4.

TAJ-Net: a two-stage clustered cell segmentation network with adaptive joint learning of spatial and spectral information.

Pulmonary adenocarcinoma is the primary cause of cancer-related death worldwide and pathological diagnosis is the "golden standard" based on the regional distribution of cells. Thus, regional cell segmentation is a key step while it is challenging due to the following reasons: 1) It is hard for pure semantic and instance segmentation methods to obtain a high-quality regional cell segmentation result; 2) Since the appearances of pulmonary cells are very similar which even confuse pathologists, annotation errors are usually inevitable. Considering these challenges, we propose a two-stage 3D adaptive joint training framework (TAJ-Net) to segment-then-classify cells with extra information as the supplementary information of information.

(2R, 6R)-hydroxynorketamine ameliorates PTSD-like behaviors during the reconsolidation phase of fear memory in rats by modulating the VGF/BDNF/GluA1 signaling pathway in the hippocampus.

Rationale: Fear memory, a fundamental symptom of post-traumatic stress disorder (PTSD), is improved by (2R, 6R)-hydroxynorketamine ((2R, 6R)-HNK) administration. However, the phase of fear memory in which the injected drug is the most effective at mitigating PTSD-like effects remains unknown.

Objective: This study aimed to explore the effects of (2 R, 6 R)-HNK administration during three phases [acquisition (AP), reconsolidation (RP), and extinction (EP)] on PTSD-like behaviors in single prolonged stress (SPS) and contextual fear conditioning (CFC) rat models.

Case report: Malignant epithelioid angiosarcoma in a Chinese female patient.

Perivascular epithelioid cell tumors (PEComas) are mesenchymal tumors that exhibit characteristic epithelioid or spindle cell morphology and typically grow around blood vessels. These tumors are characterized by the expression of melanocytic and smooth muscle markers, such as HMB-45, Melan-A, and smooth muscle actin, indicating a dual differentiation phenotype. PEComas are extremely rare diseases, and patients typically have a very poor prognosis.

Bilateral Internal Auditory Canal Metastasis From Lung Cancer on FDG PET/CT.

The occurrence of metastatic tumor in the internal auditory canal is very rare. Thus, we report FDG PET/CT findings of bilateral Internal auditory canal metastasis from lung cancer in a 67-year-old man. FDG PET/CT and MRI showed nodules in the bilateral internal auditory canal with an SUV max of 5.

Phase stabilization A-site ion anchoring for ultra-stable perovskite light emitting diodes.

A novel ion anchoring strategy stabilizes the perovskite phase, yielding ambient stable perovskite films and ultra-stable perovskite light-emitting diodes (PeLEDs) with an unprecedented operational half-lifetime over 37.2 years at 100 cd m and exceeding 27% efficiency, marking a new stability benchmark for next-generation display and lighting applications.

Advances in tumor stroma-based targeted delivery.

The tumor stroma plays a crucial role in tumor progression, and the interactions between the extracellular matrix, tumor cells, and stromal cells collectively influence tumor progression and the efficacy of therapeutic agents. Currently, utilizing components of the tumor stroma for drug delivery is a noteworthy strategy. A number of targeted drug delivery systems designed based on tumor stromal components are entering clinical trials.