Plants mitigate ecosystem nitrous oxide emissions primarily through reductions in soil nitrate content: Evidence from a meta-analysis.

Nitrous oxide (NO) is a potent greenhouse gas (GHG) and an ozone-depleting substance. The presence of plants in an ecosystem can either increase or decrease NO emissions, or play a negligible role in driving NO emissions. Here, we conducted a meta-analysis comparing ecosystem NO emissions from planted and unplanted systems to evaluate how plant presence influences NO emissions and examined the mechanisms driving observed responses.

CTBP2 contributes to cisplatin resistance in lung adenocarcinoma by inhibiting generation of reactive oxygen species.

Background: Cisplatin (CP) is commonly used for the initial treatment of lung adenocarcinoma (LUAD). Resistance to CP has long been recognized as a significant obstacle to achieving improved therapeutic outcomes. Nevertheless, the intricate molecular mechanisms underlying the phenomenon remain incompletely understood.

Foliar N O emissions constitute a significant source to atmosphere.

Nitrous oxide (N O) is a potent greenhouse gas and causes stratospheric ozone depletion. While the emissions of N O from soil are widely recognized, recent research has shown that terrestrial plants may also emit N O from their leaves under controlled laboratory conditions. However, it is unclear whether foliar N O emissions are universal across varying plant taxa, what the global significance of foliar N O emissions is, and how the foliage produces N O in situ.

Genome-Resolved Metagenomics and Denitrifying Strain Isolation Reveal New Insights into Microbial Denitrification in the Deep Vadose Zone.

The heavy use of nitrogen fertilizer in intensive agricultural areas often leads to nitrate accumulation in subsurface soil and nitrate contamination in groundwater, which poses a serious risk to public health. Denitrifying microorganisms in the subsoil convert nitrate to gaseous forms of nitrogen, thereby mitigating the leaching of nitrate into groundwater. Here, we investigated denitrifying microorganisms in the deep vadose zone of a typical intensive agricultural area in China through microcosm enrichment, genome-resolved metagenomic analysis, and denitrifying bacteria isolation.

Estimating food nitrogen and phosphorus footprints and budgeting nitrogen and phosphorus flows of Rwanda's agricultural food system during 1961-2020.

Nitrogen (N) and phosphorus (P) are limiting factors for crop production in Rwanda where food security is susceptible to inadequate agricultural techniques, especially fertilization. Understanding N and P footprints for food and their budgets under different fertilized scenarios may help to improve the nutrient use efficiency and crop yield in Rwanda, however, with little information available yet. Here, we estimated food N and P footprints and their budgets for agri-food system in Rwanda using adjusted N-P-Calculator model under fertilized, unfertilized and combined scenarios during 1961-2020.

Spatial and temporal dynamics of the bacterial community under experimental warming in field-grown wheat.

Climate change may lead to adverse effects on agricultural crops, plant microbiomes have the potential to help hosts counteract these effects. While plant-microbe interactions are known to be sensitive to temperature, how warming affects the community composition and functioning of plant microbiomes in most agricultural crops is still unclear. Here, we utilized a 10-year field experiment to investigate the effects of warming on root zone carbon availability, microbial activity and community composition at spatial (root, rhizosphere and bulk soil) and temporal (tillering, jointing and ripening stages of plants) scales in field-grown wheat ( L.

CBPH assay for the highest sensitive detection of SARS-COV-2 in the semen.

Background: Great concerns have been raised on SARS-CoV-2 impact on men's andrological well-being, and many studies have attempted to determine whether SARS-CoV-2 is present in the semen and till now the data are unclear and somehow ambiguous. However, these studies used quantitative real-time (qRT) PCR, which is not sufficiently sensitive to detect nucleic acids in clinical samples with a low viral load.

Methods: The clinical performance of various nucleic acid detection methods (qRT-PCR, OSN-qRT-PCR, cd-PCR, and CBPH) was assessed for SARS-CoV-2 using 236 clinical samples from laboratory-confirmed COVID-19 cases.

Pharmacological Targeting of Bcl-2 Induces Caspase 3-Mediated Cleavage of HDAC6 and Regulates the Autophagy Process in Colorectal Cancer.

Compound , a spiroindoline compound, exhibits antiproliferative capability against cancer cell lines. However, the exact underlying mechanism of this compound-mediated inhibitory capability remains unclear. Here, we showed that compound is an inhibitor of Bcl-2, which suppresses CRC growth by inducing caspase 3-mediated intrinsic apoptosis of mitochondria.

Nitrate as an alternative electron acceptor destabilizes the mineral associated organic carbon in moisturized deep soil depths.

Numerous studies have investigated the effects of nitrogen (N) addition on soil organic carbon (SOC) decomposition. However, most studies have focused on the shallow top soils <0.2 m (surface soil), with a few studies also examining the deeper soil depths of 0.

Anthropogenic N input increases global warming potential by awakening the "sleeping" ancient C in deep critical zones.

Even a small net increase in soil organic carbon (SOC) mineralization will cause a substantial increase in the atmospheric CO concentration. It is widely recognized that the SOC mineralization within deep critical zones (2 to 12 m depth) is slower and much less influenced by anthropogenic disturbance when compared to that of surface soil. Here, we showed that 20 years of nitrogen (N) fertilization enriched a deep critical zone with nitrate, almost doubling the SOC mineralization rate.

Reduced Acquired Resistance to Erlotinib in NSCLC by Reversing the Epithelial-Mesenchymal Transition via the FGFR/MAPK/c-fos Signaling Pathway.

For patients exhibiting non-small-cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) mutations, epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are a first-line treatment. However, most patients who initially responded to EGFR-TKIs eventually developed acquired resistance, limiting the effectiveness of therapy. It has long been known that epithelial-mesenchymal transition (EMT) leads to acquired resistance to EGFR-TKIs in NSCLC.

Differential immediate and long-term effects of nitrogen input on denitrification N2O/(N2O+N2) ratio along a 0‒5.2 m soil profile.

High nitrogen (N) input to soil can cause higher nitrous oxide (N2O) emissions, that is, a higher N2O/(N2O+N2) ratio, through an inhibition of N2O reductase activity and/or a decrease in soil pH. We assumed that there were two mechanisms for the effects of N input on N2O emissions, immediate and long-term effect. The immediate effect (field applied fertilizer N) can be eliminated by decreasing the N input, but not the long-term effect (soil accumulated N caused by long-term fertilization).

Coumarin thiazoles as unique structural skeleton of potential antimicrobial agents.

A novel type of coumarin thiazoles as unique multi-targeting antimicrobial agents were developed through four steps including cyclization, nucleophilic substitution and condensation starting from commercial resorcine. Most of the prepared coumarin thiazoles displayed favorable inhibitory potency against the tested strains. Noticeably, methyl oxime V-a exerted potent inhibitory efficacy against methicillin-resistant Staphylococcus aureus (MRSA) at low concentration (1 μg/mL) and showed broad antimicrobial spectrum.

The ecological clusters of soil organisms drive the ecosystem multifunctionality under long-term fertilization.

Long-term fertilization is known to impact the biodiversity and community structures of soil organisms, which are responsible for multiple soil ecosystem functions (multifunctionality). However the relationship between the alterations of soil organisms and ecosystem multifunctionality remains unclear, especially in the case of long-term fertilization. To explore the contribution of soil organismal biodiversity and community structures to ecosystem multifunctionality, we took soil samples from a nearly 25-year field fertilization experiment.

Relocate 10 billion livestock to reduce harmful nitrogen pollution exposure for 90% of China's population.

Livestock production in China is increasingly located near urban areas, exposing human populations to nitrogen pollution via air and water. Here we analyse livestock and human population data across 2,300 Chinese counties to project the impact of alternative livestock distributions on nitrogen emissions. In 2012 almost half of China's livestock production occurred in peri-urban regions, exposing 60% of the Chinese population to ammonia emissions exceeding UN guidelines.