Publications by authors named "ChunPeng Zhao"
Article Synopsis
- Displaced fragility fractures of the pelvis (FFP) present major challenges in orthopedic trauma, especially in older patients with weak bones and other health issues, but no robotic solutions have been documented for managing these fractures.
- A study evaluated a new robot-assisted fracture reduction system on 15 elderly patients, achieving a 100% success rate in fracture reduction and excellent recovery scores after 6 months.
- The innovative system enhances surgical precision and effectiveness, potentially transforming the treatment of FFP in an aging population by addressing the complexities associated with traditional methods.
[Effectiveness of reduction robot combined with navigation robot-assisted minimally invasive treatment for Tile type B pelvic fractures].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
August 2024
Article Synopsis
- The study aimed to assess the effectiveness of using a reduction robot and navigation robot for minimally invasive treatment of Tile type B pelvic fractures in 10 patients (average age 45.5 years).
- The procedure involved closed reduction followed by fixation of the anterior and posterior pelvic rings, with the time for fracture reduction averaging 52.3 minutes.
- Results indicated a high quality of fracture reduction (90% rated as excellent or good) and operation times averaging 215.5 minutes, with no significant complications reported during follow-up.
Article Synopsis
- Shale gas condensate is a new resource primarily composed of adsorbed methane (CH) but differs significantly between marine and continental sources in terms of organic matter and mineral composition.
- An advanced technology was used to analyze continental shale, revealing it has more clay, fewer pores, and different pore development compared to typical marine shale.
- In continental shale, inorganic minerals enhance methane adsorption more than organic matter, highlighting the importance of clay minerals for effective gas extraction.
Article Synopsis
- * Results show that the group using TCC had a higher rate of excellent and good fracture reduction (100%) compared to the control group (92.6%), and they experienced less varus angle loss and shorter recovery time for full weight-bearing.
- * However, TCC patients had significantly higher intraoperative blood loss, while no significant differences were found in Harris scores or survival rates between the two groups, suggesting TCC may enhance treatment efficacy despite the increased
Fast and precise collision detection for detailed and complex physiological structures.
Comput Methods Programs Biomed
October 2023
Article Synopsis
- Virtual reality plays a crucial role in computer-assisted surgery, particularly in surgical planning and simulations, requiring precise and efficient collision detection to enhance realism.
- This study introduces a new algorithm that combines bounding spheres formation with a two-level collision detection system to improve accuracy and computational efficiency for complex physiological structures during surgical simulations.
- Testing showed that this algorithm outperforms existing methods by producing a more compact hierarchy of bounding spheres, allowing for fast and error-free collision detection even in complicated surgical scenarios.
Article Synopsis
- The study compares the TiRobot-assisted pelvic screw fixation method to the traditional fluoroscopy-assisted percutaneous sacroiliac screw fixation for treating posterior pelvic injuries.
- A meta-analysis was performed on various databases to assess outcomes, revealing that TiRobot resulted in reduced radiation exposure, fewer guide wire attempts, less blood loss, and better screw accuracy and overall scores.
- Although TiRobot showed advantages, it did not significantly affect operative time, fracture healing time, or reduction accuracy compared to the conventional method.
Article Synopsis
- Pelvic fractures are severe injuries with high rates of mortality and disability, making their surgical treatment particularly difficult due to complex anatomy.
- This paper investigates three common holding pathways for reducing pelvic fractures, using finite element modeling to identify their effectiveness for various surgical operations.
- The findings suggest that a combined holding strategy, especially the 3-pin method, can significantly reduce the force needed during surgery, improving surgical outcomes when managing pelvic fractures.
Article Synopsis
- - The study explored the use of a robot-assisted fracture reduction (RAFR) system for minimally invasive treatment of unstable pelvic fractures, focusing on its indications, safety, and effectiveness.
- - A total of 22 patients were treated using the RAFR system, which utilizes preoperative 3D CT scans to intelligently plan and execute the optimal reduction of fractures, leading to successful outcomes.
- - Results showed a minimal average error in fracture reduction (3.41mm) and high patient satisfaction, with 95.5% of cases rated as excellent or good based on the Matta criteria.
[Orthopedic robot based on 5G technology for remote navigation of percutaneous screw fixation in pelvic and acetabular fractures].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
August 2022
Article Synopsis
- The study aimed to assess the effectiveness and safety of using a remote orthopedic robot powered by 5G technology for percutaneous screw fixation in pelvic and acetabular fractures among 15 patients between January and December 2021. !* -
- The results indicated that all patients had successful surgical outcomes, with a total of 36 screws placed; 88.89% of these screws were evaluated as excellent in positioning with no complications related to screw placement. !* -
- The average time for screw planning was about 8.7 minutes, and guidewire placement took approximately 6.8 minutes, showing efficient operation despite some communication delays in a couple of cases. !*
Article Synopsis
- Pelvic fractures are high-energy injuries that lead to significant disability and mortality, and traditional surgery can cause severe soft tissue damage and complications.
- The new intelligent robot-assisted fracture reduction (RAFR) system aims to improve the accuracy and safety of minimally invasive surgery for pelvic fractures by utilizing real-time 3D navigation.
- In tests with 20 pelvic fracture models, the RAFR system achieved impressive accuracy with mean errors of just 1.29 mm in image registration and 2.72 mm in fracture reduction, indicating its potential for clinical use.
Article Synopsis
- - Displaced pelvic fractures are highly complicated in traumatic orthopedics, often leading to significant mortality and morbidity, making effective reduction crucial for surgical treatment.
- - A newly designed robotic surgery system, specifically created for the autonomous reduction of displaced pelvic fractures, was successfully used on a real patient for the first time.
- - The surgery lasted 110 minutes and resulted in an anatomical reduction, while the paper also reviews existing literature on pelvic fracture reduction techniques and explains the principles behind the robotic system.
Objectives: To assess the efficiency, safety, and accuracy of S (IS) screw fixation using a robot-assisted method compared with a freehand method.
Methods: This is a retrospective clinical study. We analyzed the patients treated with S IS screw fixation for unstable pelvic fractures from January 2016 to January 2019 in our institution.
Deep learning to segment pelvic bones: large-scale CT datasets and baseline models.
Int J Comput Assist Radiol Surg
May 2021
Article Synopsis
- Pelvic bone segmentation is crucial for diagnosing and planning surgeries for pelvic diseases, but current methods struggle with accuracy due to various image challenges and lack large, annotated datasets.
- This study introduces a comprehensive pelvic CT dataset with 1184 volumes and proposes a deep learning network to segment key pelvic bones while also incorporating an effective post-processing technique using signed distance functions (SDF).
- Results show that the method is highly effective, yielding excellent accuracy metrics and promising improvements in segmentation outcomes, with plans to share the dataset and tools with the wider research community.
Enhanced removal of Cr(VI) using a modified environment-friendly adsorbent.
Water Sci Technol
February 2021
Article Synopsis
- - Chitosan was modified using ferric chloride and sodium laurylsulfonate to create an enhanced adsorbent, CS-Fe-SLS, which effectively removes chromium (Cr(VI)) from solutions.
- - The study found optimal conditions for adsorption at a pH of 3.0, an equilibrium time of 120 minutes, and noted interactions involving both physical and chemical processes, with maximum adsorption capacity reaching 131.91 mg/g.
- - Characterization techniques revealed significant differences between CS-Fe-SLS and regular chitosan, with CS-Fe-SLS having lower crystallinity and better Cr(VI) removal efficiency, partly due to the conversion of some Cr(VI) to Cr
Article Synopsis
- Most therapeutic recombinant proteins are produced in mammalian cell lines like CHO and HEK293F, but proteins from CHO may cause immune responses due to different glycan structures.
- This study tested eight common promoters in HEK293F cells to find which one yields the highest expression of recombinant proteins, revealing that the CAG promoter combined with the CMV enhancer produced the best results.
- Additionally, using mild hypothermia post-transfection further boosted the expression levels, confirming that the CAG promoter is highly effective in producing recombinant proteins in HEK293F cells.
Article Synopsis
- Multicistronic vectors improve transgene expression in CHO cells and help balance gene expression levels.
- This study explored the impact of two 2A peptides (P2A and T2A) on the expression of linked eGFP and RFP genes in CHO cells using tricistronic vectors.
- Results showed that P2A significantly boosted the expression of both fluorescent proteins compared to T2A, indicating its potential for enhancing recombinant protein production in CHO systems.
Article Synopsis
- The study aimed to assess the effectiveness of a bi-planar robot navigation system in placing cannulated screws for femoral neck fractures compared to conventional freehand surgery.
- During the trial with 60 patients, the robot-assisted surgery showed significantly less fluoroscopy and operation time, along with fewer adjustments needed for guide pins, resulting in better alignment and accuracy of the screws.
- Follow-up results indicated that although both methods had some complications, the robotic approach had a lower incidence of major issues like femoral head necrosis and nonunion compared to the freehand method.
Article Synopsis
- The study investigates thermal runaway (TR) and how it behaves in large lithium-ion batteries under different states of charge (SOC).
- Experiments using an advanced calorimeter reveal that TR begins at the front surface of the battery and spreads throughout, with a significantly shorter propagation time at 100% SOC compared to 50% SOC.
- The findings highlight that batteries at full charge exhibit intense combustion, whereas those at half charge produce more smoke, emphasizing the importance of SOC in the safety design of battery modules.
Article Synopsis
- Nonviral episomal vectors, particularly those using matrix attachment regions (MARs) and cytomegalovirus (CMV) promoters, offer a promising approach for gene therapy, but the CMV promoter often faces silencing issues over time.
- In this research, CHO cells (Chinese hamster ovary cells) and those lacking DNA methyltransferase showed enhanced transgene expression and stability when either treated with a DNA methylation inhibitor or genetically modified.
- The findings demonstrate that reducing DNA methyltransferase levels—notably in Dnmt3a-deficient cells—can improve the long-term expression and retention of transgenes in episomal vectors, especially when cultured for extended periods.
Article Synopsis
- * Traditional surgical methods like open reduction internal fixation have risks such as excessive bleeding and infection, prompting the rise of minimally invasive techniques like percutaneous lag screw placement that are effective but present challenges due to the complex pelvic anatomy.
- * Robotic-assisted surgery enhances the accuracy of screw placement by using preoperative imaging and real-time tracking, thereby minimizing the risks of misplacement, nerve damage, and radiation exposure associated with traditional methods; this guide illustrates the use of the TiRobot system to standardize robotic applications in orthopedic procedures.
Two human MARs effectively increase transgene expression in transfected CHO cells.
J Cell Mol Med
February 2019
Article Synopsis
- Matrix attachment regions (MARs) improve transgene expression in CHO cells, but their full functionality and mechanism are not well understood.
- This study identified two effective MAR elements from human DNA, MAR-3 and MAR-7, which demonstrated enhanced expression of the enhanced green fluorescent protein (eGFP) when used in transfected CHO cells.
- Results indicated that cells with MAR-containing vectors showed higher eGFP expression levels, and MAR-7 outperformed MAR-3, suggesting that the presence of MARs increases both eGFP copy numbers and mRNA expression.
Article Synopsis
- The authors requested the retraction of their paper.
- The retraction indicates that the paper is no longer considered valid or credible.
- Readers should disregard the findings and conclusions of the retracted paper.
[Effects of Different Promoters and Combinations on Transgene Expression of Recombinant CHO Cells].
Sichuan Da Xue Xue Bao Yi Xue Ban
January 2018
Article Synopsis
- The study aims to investigate how different promoters and matrix attachment regions (MAR) affect transgene expression in CHO cells.
- It combines various promoters with a MAR in expression vectors, transfects them into cells, and measures the expression of enhanced green fluorescent protein (eGFP) using flow cytometry and qPCR.
- Results reveal that the tested promoter is more effective than another, and the presence of MAR enhances transgene expression by increasing gene copy numbers.
Article Synopsis
- Low-level and unstable transgene expression in CHO cell systems is a common problem, but matrix attachment regions (MARs) can enhance these expression levels, requiring further research for optimization.
- In a study analyzing two new MARs and MAR-6, one new element, the human CSP-B MAR, was identified as significantly boosting transgene expression in recombinant CHO cells.
- Bioinformatics suggested that specific elements within the MAR sequences, NFAT and VIBP, may play a role in this enhancement of eGFP expression.