Increased physical activity frequency in primary school adolescents is related to reduced risk of self-reported adverse mental health symptoms.

Purpose: The sedentary lifestyle and mental health issues of primary school students are major public health issues in China and globally. Some studies have shown that regular physical activity is beneficial to health, but there are few epidemiological investigations on the relationship between physical activity and psychological problems. The purpose of this study is to explore the relationship between physical activity and mental health.

Altered Nigral Amide Proton Transfer Imaging Signal Concordant With Motor Asymmetry in Parkinson's Disease: A Multipool CEST MRI Study.

Asymmetry is a natural characteristic of Parkinson's disease (PD), which can be used to distinguish PD from atypical parkinsonism. Chemical exchange saturation transfer (CEST) has demonstrated value in reflecting the subtle changes related to neuron loss and abnormal protein accumulation in PD but has not been used to investigate asymmetry in PD. This study aimed to examine asymmetrical changes in the mesencephalic nucleus of PD patients with motor asymmetry using four-pool CEST analysis and to explore the relationship between imaging asymmetry and motor asymmetry.

Mogroside V protects Lipopolysaccharides-induced lung inflammation chicken via suppressing inflammation mediated by the Th17 through the gut-lung axis.

Lipopolysaccharide (LPS) exposure triggers pulmonary inflammation, leading to compromised lung function in broiler. As amplified by policy restrictions on antibiotic usage, seeking antibiotic alternatives has become imperative. Mogroside V (MGV) has been reported to have a beneficial role in livestock and poultry production due to its remarkable anti-inflammatory effects.

Strong and Tough Self-Healing Elastomers via BTA-Mediated Microstructure and Metal-ligand Coordination.

Creating elastomers with high strength, toughness, and rapid self-healing remains a key challenge. These seemingly contradictory properties require innovative design strategies. Herein, a novel approach is proposed by simultaneously incorporating a unique triple hydrogen bond unit, benzene-1,3,5-tricarboxamide (BTA), and imidazole-Zn dynamic coordination into the elastomer.

Dynamics of antibiotic resistance in poultry farms via multivector analysis.

This study examines the distribution of microbial communities and antibiotic resistance genes (ARGs) across various vectors in poultry farm environments. The results show that airborne particulate matter (PM) and soil harbor the highest counts of microbial genes, exceeding those found in poultry visceral samples, which display lower microbial diversity and ARG levels. This highlights environmental vectors, particularly soil and PM, as major reservoirs for ARGs.

Supine bicycle stress echocardiography at low altitude for identification of susceptibility to acute mountain sickness.

Background: Exposure to high altitude may unpredictably lead to acute mountain sickness (AMS). The purpose of this study was to identify the predictors of AMS at low altitude by exercise stress echocardiography (ESE).

Methods: A total of 40 healthy adults were enrolled and underwent comprehensive supine bicycle ESE at low altitude, including pulmonary vascular resistance (PVR), right ventricular (RV) area index at the end of diastole (RVEDAi), B-lines, and inferior vena cava (IVC) diameter.

Distribution and environmental dissemination of antibiotic resistance genes in poultry farms and surrounding ecosystems.

Antibiotic resistance poses a significant threat to human and animal health worldwide, with farms serving as crucial reservoirs of Antibiotic Resistance Genes (ARGs) and Antibiotic-resistant bacteria. However, the distribution of ARGs in poultry farms and their transmission patterns in the environment remain poorly understood. This study collected samples of aerosol microorganisms, cloacal matter, soil, and vegetables from poultry farms and surrounding environments at three different distances.

Declining Influenza Vaccination Uptake, Attitudes, and Knowledge Among Healthcare Workers in Chengdu, China, in the Post-COVID-19 Era.

Purpose: Despite the benefits of influenza vaccination, particularly for healthcare workers (HCWs) at higher risk, vaccination coverage among HCWs in China remains low. This study aims to provide updated insights into the knowledge, attitudes, practices, and barriers related to influenza vaccination among HCWs in China post-COVID-19 era, to inform strategies for improving vaccination rates and healthcare safety.

Methods: A cross-sectional survey was conducted between December 2023 and January 2024 at two tertiary hospitals in Chengdu, China.

Administration time modify the anxiolytic and antidepressant effects of inulin via gut-brain axis.

An imbalance in the microbiota-gut-brain axis exerts an essential effect on the pathophysiology of depressive and anxiety disorders. Our previous research revealed that the timing of inulin administration altered its effects on chronic unpredictable mild stress (CUMS)-induced anxiety and depression. However, it is still unclear if the gut-brain axis is primarily responsible for these effects.

polymorphisms and endometrial cancer risk: validation of identified loci and evaluation of novel variants.

Background: This study aimed to validate HNF1B single nucleotide polymorphisms (SNPs) associated with endometrial cancer risk in a Chinese Han population and explore novel SNPs. Our findings enhance the understanding of genetic components and are crucial for detection strategies and personalized medicine.

Methods: We genotyped four HNF1B SNPs in 637 patients and 667 controls using Agena MassARRAY.

Guiding adjuvant radiotherapy in stage III endometrial cancer: a prognostic model based on SEER.

Background: The effect of overall survival (OS) with adjuvant radiotherapy in stage III endometrial cancer (EC) remains controversial, and the adverse invents were unignorable.

Methods: A total of 4,064 stage III EC patients who underwent adjuvant chemotherapy post-operatively were selected from Surveillance, Epidemiology, and End Results (SEER) Program. Independent risk factors were identified through Cox regression models.

LPM682000012, a Synthetic Neuroactive Steroid That Ameliorates Epileptic Seizures by Downregulating the /NF-κB Signaling Pathway.

Epilepsy is characterized by abnormal neuronal firing in the brain. Several therapeutic strategies exist for epilepsy; however, several patients remain poorly treated. Therefore, the development of effective treatments remains a high priority in the field.

Oxidative Stress in Poultry and the Therapeutic Role of Herbal Medicine in Intestinal Health.

The intensive broiler farming model has accelerated the development of the poultry farming industry. However, it has also inevitably brought about many stressors that lead to oxidative stress in the organism. The intestine is the leading site of nutrient digestion, absorption, and metabolism, as well as a secretory and immune organ.

Effects of Essential Oil Blends Supplementation on Growth Performance, Meat Physiochemical Parameters, Intestinal Health and Lipid Metabolism of Weaned Bamei Piglets.

The benefits of plant essential oils (EO) on the health of animals have been frequently reported, but their alteration of lipid metabolism in obese pigs has yet to be explored. This study aimed to assess the impact of EO blends (oregano, cinnamon and lemon oils) on growth performance, meat physicochemical parameters, intestinal health and lipid metabolism in the small intestine of weaned Bamei (a kind of obese-type pig) piglets. One hundred and forty-four male 60-day-old weaned Bamei piglets were randomly assigned to three groups of six replicates each: CON (basal diet), T1 (basal diet + 250 mg/kg EO), and T2 (basal diet + 500 mg/kg EO) over 28 days.

LDH-derived CoNiTe dispersed in 3D carbon sheets as a separator modifier to enable kinetics-accelerated lithium-sulfur batteries.

Lithium-sulfur batteries are considered powerful candidates for the next generation of advanced energy-storage systems owing to their high energy density and theoretical specific capacity. However, their practical commercial feasibility has been hampered by their sluggish kinetics and severe shuttle effect. Hence, a novel hybrid comprising NiCo-LDH-derived CoNiTe nanoparticles grafted on 3D carbon sheets was rationally constructed through facile steps and served as a functional separator modifier for a lithium-sulfur battery.

C. elegans PPEF-type phosphatase (Retinal degeneration C ortholog) functions in diverse classes of cilia to regulate nematode behaviors.

Primary (non-motile) cilia represent structurally and functionally diverse organelles whose roles as specialized cellular antenna are central to animal cell signaling pathways, sensory physiology and development. An ever-growing number of ciliary proteins, including those found in vertebrate photoreceptors, have been uncovered and linked to human disorders termed ciliopathies. Here, we demonstrate that an evolutionarily-conserved PPEF-family serine-threonine phosphatase, not functionally linked to cilia in any organism but associated with rhabdomeric (non-ciliary) photoreceptor degeneration in the Drosophila rdgC (retinal degeneration C) mutant, is a bona fide ciliary protein in C.

Impact of continuous care on quality life of patients with inflammatory bowel disease based on multi-disciplinary cooperation on WeChat platform.

Background: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is characterized by chronic recurrent intestinal inflammation, and its primary clinical manifestations are abdominal pain, diarrhea, hematochezia, etc., which seriously affects patients' quality of life.

Objective: To explore the impact of continuing empowerment education based on Roy's adaptation theory on disease uncertainty and self-management ability in patients with inflammatory bowel disease.

Fabrication and Mechanism Insight of Multidimensional Coupled Metal-Free van der Waals Heterostructures for Enhanced Photocatalytic Hydrogen Evolution.

It is an arduous issue to significantly improve the charge separation efficiency of polymer photocatalysts due to their inherently high exciton binding energy. Herein, based on an interfacial coupling and atom diffusion strategy, a metal-free 3D/2D van der Waals (VdW) heterojunction is fabricated through the modification of rich-vacancy wrinkle-like S (Vs-S) microspheres on the surface of S-doped polymeric carbon nitride (S-PCN) nanosheets. The insight into the mechanism reveals that the interfacial coupling effect induces a strong built-in electric field from S-PCN to Vs-S, and the carrier transfer behavior abides by the type-II charge transfer pathway, thereby dramatically improving the separation efficiency and transport kinetics of photogenerated carriers.

Complement activation targeted inhibitor C2-FH ameliorates acetaminophen-induced liver injury in mice.

Background: Complement activation is recognized as an important factor in the progression of liver damage caused by acetaminophen (APAP). However, the role of the complement inhibitor C2-FH in APAP-induced liver injury remains unclear.

Aim: To explore C2-FH in protecting against APAP-induced liver injury by inhibiting complement activation.

Deoxynivalenol mycotoxin dietary exposure on broiler performance and small intestine health: A comprehensive meta-analysis.

The effect of DON mycotoxins on broiler production performance and the small intestine is a critical factor in the health and well-being of broilers. Several studies have been conducted on this topic and have reported varying results and conclusions. Therefore, it is necessary to conduct systematic reviews and meta-analyses to thoroughly examine and draw unique conclusions.

Protective Effects of Astaxanthin against Oxidative Stress: Attenuation of TNF-α-Induced Oxidative Damage in SW480 Cells and Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in C57BL/6 Mice.

In this study, we investigated the protective effects of astaxanthin (AST) against oxidative stress induced by the combination of azoxymethane (AOM) and dextran sulfate sodium (DSS) in colitis-associated cancer (CAC) and TNF-α-induced human colorectal cancer cells (SW480), as well as the underlying mechanism. In vitro experiments revealed that astaxanthin reduced reactive oxygen species (ROS) generation and inhibited the expression of Phosphorylated JNK (P-JNK), Phosphorylated ERK (P-ERK), Phosphorylated p65 (P-p65), and the NF-κB downstream protein cyclooxygenase-2 (COX-2). In vivo experiments showed that astaxanthin ameliorated AOM/DSS-induced weight loss, shortened the colon length, and caused histomorphological changes.

A methodological guide for implementing and interpreting results of probabilistic analysis.

Introduction: Probabilistic analysis, also referred to as probabilistic sensitivity analysis (PSA), is used extensively in cost-effectiveness evaluations of health technologies. We present methodological guidance for implementing probabilistic analysis and interpreting its results for policy and decision-making.

Methods: We review the methodological issues related to common practices in probabilistic analysis, explore aspects that are currently not widely addressed in the health economics literature, and provide an overview of recent methodological developments.