Effects of the Early Start Denver Model on emotional dysregulation and behavior problems in children with Autism spectrum disorder : Effects of the early start Denver model on emotional dysregulation and behavior problems in Chinese children with Autism spectrum disorder.

Background: Most previous studies have focused on the clinical efficacy after intervention of ESDM, particularly in core symptoms. However, only a few have paid attention to the effectiveness of ESDM on emotional dysregulation and behavior problems in children with ASD. This study aimed to explore the effect of the ESDM on addressing emotional dysregulation and behavior problems in children with ASD in China, as well as its correlation with core symptoms of ASD.

What do ultrasound vocalizations really mean in rats with different origins of pain?

Objectives: This study is to assess how 22 kHz and 50 kHz spontaneous ultrasound vocalization (USV) calls would be affected by different origins of pain so as to validate the use of USV in pain studies.

Methods: Five well-established rat models of pain were used to evaluate various parameters of spontaneous 22 kHz and 50 kHz calls in adult male rats in terms of both acute and chronic or inflammatory and neuropathic or somatic and visceral origins. The effects of local lidocaine blockade of the injection site and intraperitoneal administration of antidepressant (amitriptyline) and anticonvulsant (gabapentin) were examined as well in typical inflammatory and neuropathic pain models, respectively.

Conjugated Phthalocyanine-Based Mesoporous Covalent Organic Frameworks for Efficient Anodic Lithium Storage.

Organic anode materials have been recognized as promising candidates for low-cost and sustainable lithium-ion batteries (LIBs), which however suffer from the inferior cycling stability and low conductivity with unsatisfactory LIBs performance. Herein, two conjugated phthalocyanine-based covalent organic frameworks (COFs), namely CoPc-Ph-COF and CoPc-3Ph-COF, are synthesized by the nucleophilic substitution reaction of hexafluorophthalocyanine cobalt (II) (CoPcF) with 1,2,4,5-tetrahydroxybenzene and 9,10-dimethyl-2,3,6,7-tetrahydroxyanthracene, respectively. Powder X-ray diffraction and electron microscopy analysis reveal the crystalline porous structure of both COFs with a pore size of 1.

Additive manufacturing technology in the development of easy to swallow and digest foods for the elderly.

The ageing of the population is a major challenge for the world. The elderly face a number of functional deteriorations in the body during the ageing process. Among these, swallowing and digestion are the two biggest challenges that elderly individuals face.

Construction and Circularly Polarized Luminescence of Thiophene-Based Multiple Helicenes.

Thiophene-based monohelicene (), triple helicenes (), and hexapole helicenes () were synthesized via oxidative photocyclization and cascade Suzuki/intramolecular cyclization as the crucial steps. The enantiomers of , , and exhibited circularly polarized luminescence (CPL), and the luminescence dissymmetry factors () gradually increased from -5.1 × 10 to -2.

Development of fully automated models for staging liver fibrosis using non-contrast MRI and artificial intelligence: a retrospective multicenter study.

Background: Accurate staging of liver fibrosis (LF) is essential for clinical management in chronic liver disease. While non-contrast MRI (NC-MRI) yields valuable information for liver assessment, its effectiveness in predicting LF remains underexplored. This study aimed to develop and validate artificial intelligence (AI)-powered models utilizing NC-MRI for staging LF.

Computed tomography-based radiomics and body composition analysis for predicting clinically relevant postoperative pancreatic fistula after pancreaticoduodenectomy.

Background: Preoperative risk assessment of clinically relevant postoperative pancreatic fistula (CR-POPF) is still lacking. This study aimed to develop and validate a combined model based on radiomics, pancreatic duct diameter, and body composition analysis for the prediction of CR-POPF in patients undergoing pancreaticoduodenectomy (PD).

Methods: Multivariable logistic regression was used to construct a combined model in conjunction with radiomics score (Rad-score), pancreatic duct diameter, and visceral fat area/total abdominal muscle area index (VFA/TAMAI).

Case report: Recurrence of primary hepatic neuroendocrine tumors after resection of liver segments IV in 8 years follow-up.

Background: Primary hepatic neuroendocrine tumors (PHNETs) are an utterly rare entity. The diagnosis of PHNETs could legitimize when an extrahepatic primary NET must always be excluded. PHNETs can achieve a high survival rate after complete surgical resection, however, most patients still have an 18% risk of recurrence within 5 years after surgery.

The downregulation of SASH1 expression promotes breast cancer occurrence and invasion accompanied by the activation of PI3K-Akt-mTOR signaling pathway.

SASH1 (SAM and SH3 domain containing 1) has been increasingly reported as a tumor suppressor gene. However, there is limited research on the role of SASH1 in breast cancer. This manuscript aims to investigate the mechanism of SASH1 in the occurrence, development, and prognosis of breast cancer.

Indirect prediction of the 3D printability of polysaccharide gels using multiple machine learning (ML) models.

In this paper, the capabilities of NIR spectroscopy and LF-NMR data were compared for rapidly predicting the rheological properties of polysaccharide gels and assessing their printability. Seven machine learning (ML) models were established for rheological property prediction based on partial least squares regression (PLSR), support vector regression (SVR), back propagation artificial neural network (BPANN), one-dimensional convolutional neural network (1D CNN), recurrent neural network (RNN), long short-term memory (LSTM), and Transformer. The results showed that among the seven models, the SVR, BPANN, and 1D CNN models based on NIR spectroscopy effectively predicted the rheological parameters of polysaccharide gels, with the highest R in the prediction set reaching 0.

Engineering extracellular vesicles derived from endothelial cells sheared by laminar flow for anti-atherosclerotic therapy through reprogramming macrophage.

Extracellular vesicles (EVs) secreted by endothelial cells in response to blood laminar flow play a crucial role in maintaining vascular homeostasis. However, the potential of these EVs to modulate the immune microenvironment within plaques for treating atherosclerosis remains unclear. Here, we present compelling evidence that EVs secreted by endothelial cells sheared by atheroprotective laminar shear stress (LSS-EVs) exhibit excellent immunoregulatory effects against atherosclerosis.

Valnemulin restores colistin sensitivity against multidrug-resistant gram-negative pathogens.

Colistin is one of the last-resort antibiotics in treating infections caused by multidrug-resistant (MDR) pathogens. Unfortunately, the emergence of colistin-resistant gram-negative strains limit its clinical application. Here, we identify an FDA-approved drug, valnemulin (Val), exhibit a synergistic effect with colistin in eradicating both colistin-resistant and colistin-susceptible gram-negative pathogens both in vitro and in the mouse infection model.

Computed tomography (CT)-based skeletal muscle vertebral-related index to assess low muscle mass in patients with non-small cell lung cancer.

Background: Patients with lung cancer accompanied by sarcopenia may have a poor prognosis. Normally, low muscle mass associated with sarcopenia is assessed using the skeletal muscle index (SMI). It remains unclear whether the standardized skeletal muscle area (SMA) using 2-dimensional (2D) vertebral metrics (called the skeletal muscle vertebral related index, SMVI) could substitute for SMI when it is missing.

Porcine beta defensin 2 attenuates inflammatory responses in IPEC-J2 cells against Escherichia coli via TLRs-NF-κB/MAPK signaling pathway.

Background: Porcine beta defensin 2 (pBD2) is one of the porcine beta defensins that has antibacterial activity, and plays an important role in the immunomodulatory activity that protects cells from pathogens. It has been reported that pBD2 plays their immunomodulatory functions related to the TLR4-NF-κB signal pathways. However, it is not completely clear how pBD2 reduces the inflammatory response caused by pathogens.

Improvement of 3D printing age-friendly brown rice food on rough texture, swallowability, and in vitro digestibility using fermentation properties of different probiotics.

Probiotics can promote the balance of the intestinal microbial community and enhance the biological activity of food. They are beneficial to the health of elderly people. Therefore, five different probiotics (4% of the total weight) were added to pasted brown rice to study the printability, swallowability, and digestibility of fermented inks (at 40 °C for 10 h).

Sampling-rate calibration vs. equilibrium calibration for in vivo solid-phase microextraction: Analysis of neonicotinoids in bananas.

In vivo solid-phase microextraction (in vivo SPME) is an emerging fascinating sample pretreatment technique, but its quantitative correction method is different from the traditional correction methods, which has become a bottleneck limiting its development. At present, the sampling-rate calibration and equilibrium calibration are mainly used, however, their characteristics and applicability are not clear. In this study, the sampling-rate calibration and equilibrium calibration were evaluated in the case of the determination of neonicotinoids in bananas by in vivo SPME.

Diffusion-tensor magnetic resonance imaging as a non-invasive assessment of extracellular matrix remodeling in lumbar paravertebral muscles of rats with sarcopenia.

Background: Extracellular matrix (ECM) remodeling in skeletal muscle is a significant factor in the development of sarcopenia. This study aims to evaluate changes in ECM remodeling in the lumbar paravertebral muscles of sarcopenic rats using diffusion-tensor magnetic resonance imaging (DT-MRI) and compare them with histology.

Methods: Twenty 6-month-old female Sprague Dawley rats were randomly divided into the dexamethasone (DEX) group and the control (CON) group.