Correlation of serum Orexin-A level with cognitive function and serum inflammatory cytokines in epileptic patients.

Objective: This study was designed to analyze the associations of serum Orexin-A level with cognitive function and serum inflammatory cytokines in epileptic patients.

Methods: Totally 77 epileptic patients treated in Suqian First Hospital between January 2019 and January 2022 were retrospectively analyzed as the observation group, and 65 healthy individuals who had a physical examination in Suqian First Hospital during the same period were enrolled as the control group. The Mini-Mental State Examination (MMSE) was conducted in participants in the two groups, and the enzyme-linked immunosorbent assay (ELISA) was conducted for quantifying serum Orexin-A, interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α).

Functionalized Ferroferric Oxide Nanomagnetic Beads for Extraction of Nucleic Acid and Its Application in Early Screening of Colorectal Cancer.

Early screening is an important way to reduce the incidence and mortality of colorectal cancer (CRC). Fecal DNA testing stands out among many screening methods due to its high sensitivity. However, at this stage, researchers have not found a high-efficiency method for fecal DNA extraction.

[High-resolution Estimation of Spatio-temporal Variation in PM Concentrations in the Beijing-Tianjin-Hebei Region].

This study developed a two-stage statistical model (linear mixed effect (LME) model+geographical weight regression (GWR) model) to determine the spatio-temporal variation of PM concentrations in the Beijing-Tianjin-Hebei (BTH) region with full-coverage, high resolution, and high accuracy. The model employs multi-angle implementation of atmospheric correction aerosol optical depth (MAIAC AOD) data, with a 1 km spatial resolution, as the main predictor and meteorological data/land-use data as the auxiliary predictors. To determine the characteristics of heavy PM pollution in the BTH region, unique predictors such as AOD were also introduced into the two-stage model.

Value of Magnetic Resonance Diffusion Tensor Imaging Combined with Quantitative Electroencephalogram in Diagnosis of Neurocognitive Impairment in Patients with White Matter Demyelination.

This paper aimed to explore the clinical value of combined adoption of magnetic resonance diffusion tensor imaging (DTI) and quantitative electroencephalogram (QEEG) in assessing microstructure changes and mild neurocognitive dysfunction in patients with white matter demyelination. 128 cases of white matter demyelination admitted to the hospital from October 2018 to October 2019 were rolled into the research group, and 100 healthy patients physically examined during the same period were rolled into the control (ctrl) group. QEEG and magnetic resonance DTI examinations were performed for all patients.

[Combination of apparent diffusion coefficient and amplitude-integrated electroencephalogram to predict the outcome of comatose patients with severe traumatic brain injury].

Objective: To examine whether the combination of quantitative regional apparent diffusion coefficient (ADC) and amplitude-integrated electroencephalogram (aEEG) can predict the outcome of comatose patients with severe traumatic brain injury (sTBI).

Methods: A prospective study was conducted. The patients with coma caused by sTBI [Glasgow coma scale (GCS) < 8] admitted to Suqian First Hospital from January 2016 to June 2019 were enrolled.

Response of the critically endangered Przewalski's gazelle (Procapra przewalskii) to selenium deprived environment.

Selenium (Se) is an essential mineral nutrient for animals. Se deprivation can lead to many disorders and even death. This study investigated the response of Przewalski's gazelle (P.

Effects of Nano-copper on Antioxidant Function in Copper-Deprived Guizhou Black Goats.

Guizhou black goats are essential to the production system in the Wumeng prairie in the Western China. This study aimed to determine the influence of nano-copper on antioxidant system in copper-deprived Guizhou black goats. We analyzed mineral contents in soil, forage, and goats' tissues.

Responses of Chinese Merino Sheep (Junken Type) on Copper-Deprived Natural Pasture.

To research responses of Chinese Merino Sheep (Junken type) to copper-deprived natural pasture, we analyzed mineral contents in soil, forage, and sheep tissues. Physiological and biochemical parameters were also determined. Results showed that copper concentrations in soil and forage from affected pastures were significantly lower than those in healthy ranges (P < 0.

Limb-shaking transient ischemic attack with facial muscles involuntary twitch successfully treated with internal carotid artery stenting.

Introduction: Limb-shaking transient ischemic attack (LS-TIA) is a clinical disease with severe carotid stenosis, which is characterized by unilateral rhythmic dance or tremor like involuntary movements of arms and/or legs, but facial muscles are usually unaffected.

Methods: Today, we report a 42-year-old man with transient ischemic attack who suffered from right limb shaking and right facial muscle twitching due to the obvious stenosis of left internal carotid artery (ICA). Written informed consent was obtained from participants according to the Declaration of Helsinki, and a local ethic committee approved the study.

Effects of Nano-Zinc on Immune Function in Qianbei-Pockmarked Goats.

Qianbei-pockmarked goats are vital to the production system of western China. This study aimed to determine the influence of nano-zinc on immune function in zinc-deprived goats. We analyzed the mineral concentrations in soil, forage, and animal tissue.

Responses of Przewalski's Gazelle (Procapra przewalskii) to Zinc Nutrition in Physical Habitat.

To study responses of Procapra przewalskii to zinc (Zn) nutrition in physical habitat, we analyzed the content of mineral elements in soil, forage, and animal tissues. Physiological and biochemical indexes were also determined. The results showed that Zn contents in the soil and forage from affected pasture were significantly lower (P < 0.

Effects of Nano-Copper Poisoning on Immune and Antioxidant Function in the Wumeng Semi-Fine Wool Sheep.

The Wumeng semi-fine wool sheep is vital to the production system of the Wumeng mountainous area in Southwest China. To study the effect of nano-copper poisoning in the Wumeng semi-fine wool sheep, nano-copper poisoning model was established in sheep. We determined blood physiological and biochemical parameters, immune indexes, and antioxidant indicators.

Effect of Heavy Metal Contamination in the Environment on Antioxidant Function in Wumeng Semi-fine Wool Sheep in Southwest China.

Many environmental accidents have led to worldwide heavy metal pollution, raising concern about heavy metal toxicity in Southwest China. To study the effects of Cd and Pb in the environment on antioxidant function in Wumeng semi-fine wool sheep, contents of Cu, Zn, Mn, Mo, Fe, Se, Cd, and Pb were measured in irrigation water, soil, herbage, and animal tissues. Hematological and biochemical parameters were also determined.

Effects of Environmental Zinc Deficiency on Antioxidant System Function in Wumeng Semi-fine Wool Sheep.

The purpose of this study was to explore the effect of zinc deficiency on the antioxidant system function in Wumeng semi-fine wool sheep. The content of mineral elements in soil, forage, and animal tissues were analyzed by inductively coupled plasma atomic emission spectrometry. The blood parameters were analyzed by automatic blood cell analyzer, and the serum biochemical indexes were analyzed by automatic biochemical analyzer.

Studies of Selenium Deficiency in the Wumeng Semi-Fine Wool Sheep.

Wumeng semi-fine wool sheep are affected by a disease, characterized by emaciation, stiffness and trembling of the limbs, weakness and inability to stand, and sudden death. The objective of the study was to determine possible relationships between the disease and mineral deficiencies. Samples of wool, blood, and liver were collected from affected and healthy sheep.

iTRAQ-based proteomic analysis to identify molecular mechanisms of the selenium deficiency response in the Przewalski's gazelle.

The Przewalski's gazelle shows long-term survival in a selenium (Se)-deficient environment, but fails to exhibit obvious pathological manifestations. To reveal proteomic changes in the Przewalski's gazelle in response to Se-deficiency, twenty Przewalski's gazelle were randomly divided into control group and Se-deficient group. After induction of Se-deficiency animal model, blood samples were collected from eight animals.

The comparison of clonidine, arginine and both combined: a growth hormone stimulation test to differentiate multiple system atrophy from idiopathic Parkinson's disease.

This study was aimed at comparing the diagnostic accuracy of the growth hormone (GH) response to clonidine, arginine and both combined in order to establish a more reliable test to differentiate parkinsonism type multiple system atrophy (MSA-p) from Parkinson's disease (PD). Twenty-four patients with MSA-p and 26 cases with PD entered the study. They were submitted to treatments of clonidine, arginine and a combination of the two in a random manner on three different nonconsecutive days.

Sinomenine, an antirheumatic alkaloid, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalolmyelitis.

The therapeutic value of an antirheumatic alkaloid, sinomenine (SIN), was investigated in the acute experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). SIN is a bioactive alkaloid derived from the Chinese medicinal plant, Sinomenium acutum REHDER & E. H.