Publications by authors named "ChunHua Liu"

Emodin has shown certain anti-rheumatoid arthritis (RA) activity in preliminary studies. However, the precise mechanisms of emodin's anti-RA effects, particularly its direct targets, remain unclear. This study aimed to evaluate the anti-RA activity of emodin and elucidate its potential mechanisms, with a specific focus on identifying its molecular targets.

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In infants, high fever is associated with robust microglial morphological changes, including process retraction and soma enlargement, which contribute to fever-induced seizures. The molecular mechanisms underlying dynamic process retraction during hyperthermia remain poorly understood. Using a hyperthermia-induced microglial activation model in postnatal day 8 mice, we identified the CXCL1-CXCR1 interaction as a key regulator of process retraction.

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Lactylation is widely involved in cellular processes and is pivotal in inflammation and immune regulation. However, the expression and clinical significance of lactylation in rheumatoid arthritis (RA) remain unclear. This study aimed to determine the role of lactylation in RA and its association with immune cell infiltration.

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The dual pressure of anthropogenic activities and frequent extreme weather events has triggered a transition from macrophyte to algal dominance in shallow lakes. Phosphorus (P) is the key driver of regime shifts that can lead to a decline in the stability and resilience of lake ecosystems. However, the mechanisms underlying such regime shifts, and the effects of state transitions on internal P loading during macrophyte restoration in large shallow eutrophic lakes, remain to be fully elucidated.

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Background: Oxidative stress is linked to cognitive decline in the elderly. Diet, as a key energy source, affects brain function and serves as a modifiable risk factor for cognitive decline.

Objective: This study investigates the relationship between the Oxidative Balance Score (OBS), which reflects diet and lifestyle impact on oxidative stress, and cognitive function in older adults.

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The gene ETV6 has been confirmed to be a genetic susceptibility gene for thrombocytopenia and leukemia. Here, we report a long-chain noncoding RNA AC010198.2 as a novel fusion partner of ETV6, showing a karyotype of del(12)(p13p11), with poor prognosis in a post-MPN AML that has never been reported, which may be an vital initial event in the transformation of MPN to AML and deterioration of disease.

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Purpose: Postherpetic neuralgia (PHN) is a type of refractory neuropathic pain that causes significant suffering, disability, economic loss, and medical burden. In this study, we aim to evaluate the efficacy and safety of interferon (IFN)-α1b injection into the intervertebral foramen of patients with PHN.

Patients And Methods: This is a study protocol for a randomized, double-blind placebo-controlled multicenter clinical trial.

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Background: Accurate differentiation between benign and malignant pancreatic lesions is critical for effective patient management. This study aimed to develop and validate a novel deep learning network using baseline computed tomography (CT) images to predict the classification of pancreatic lesions.

Methods: This retrospective study included 864 patients (422 men, 442 women) with confirmed histopathological results across three medical centers, forming a training cohort, internal testing cohort, and external validation cohort.

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Background: The efficacy of the 14-day esomeprazole-amoxicillin (EA) dual therapy in eradicating () has been widely discussed previously. Vonoprazan, a novel potassium-competitive acid blocker, presents rapid, potent, and long-lasting acid inhibitory effects compared to esomeprazole. However, there is currently a scarcity of direct comparisons between the 10-day vonoprazan-amoxicillin (VA) and the 14-day EA dual therapy for eradication.

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Objective: To identify the feasibility, acceptability, and effectiveness of web-based acceptance and commitment therapy (ACT) on health-related outcomes in patients with lung cancer.

Methods: A feasibility, prospective, parallel, individual-based, assessor-blinded randomized controlled trial was designed. This study was conducted at a third-level hospital in Sichuan Province, China.

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The release of nitrogen and phosphorus from sediments, known as internal nutrient loading, plays a crucial role in determining the eutrophic state of lakes and the timeframe for their ecological recovery. The restoration of submerged macrophytes is considered an effective measure to improve lake eutrophication. However, the impact of submerged macrophytes restoration on the storage and transformation mechanisms of nitrogen and phosphorus in lake sediment-water systems has not yet been systematically studied.

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Background: Triptans selectively agoniste 5-Hydroxytryptamine(5-HT) receptors and are widely used in the treatment of migraine. Nevertheless, there is a dearth of comprehensive real-world clinical research on the safety of triptans. In light of the growing prevalence of migraine, it is imperative to gain a deeper understanding of the true extent of adverse events (AEs) associated with triptans in the clinical management of migraine.

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Three new compounds, including two glycosides, named gerbelavinsides E/G (/), and a flavone, named gerbelavin G (), were isolated from 50% ethanol extract of . Their structures were elucidated based on HR-ESI-MS, IR, UV and NMR spectral data, and the absolute configurations of and were determined by ECD spectra. Three compounds were tested for their inhibition effect against LPS-induced NO production in RAW 264.

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L. (PO) has demonstrated notable efficacy in treating coronary heart disease. Previous research identified eight key active components in PO for cardiomyocyte protection, but the underlying mechanisms remained unclear; Methods: Network pharmacology and molecular docking were used to identify potential target proteins of PO's active components.

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Article Synopsis
  • Pins and its mammalian counterpart LGN are essential for asymmetric cell division (ACD) and act as a conformational switch through their TPR repeats and GoLoco motifs.
  • The study reveals that Pins' GoLoco motifs specifically bind to GDP-loaded Gα, with Pins capable of interacting with multiple Gα·GDP molecules, partially opening its autoinhibited structure.
  • Findings challenge previous beliefs by highlighting Gα's significant role in regulating Pins' conformation, clarifying its involvement in the ACD pathway.
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  • - The study aimed to create a contrastive language-image pretraining (CLIP) model that utilizes transfer learning and self-attention techniques to predict the tumor-stroma ratio (TSR) in pancreatic ductal adenocarcinoma from preoperative CT scans, which could help with cancer risk assessment and treatment strategies.
  • - A total of 207 patients were examined, and a new CLIP-adapter model was developed, which integrates various imaging features and was compared against existing traditional and deep learning models to evaluate prediction accuracy.
  • - Results indicated that the CLIP-adapter model, particularly the CLIP-adapter_ViT_Base_32 version, outperformed other models in predicting TSR, achieving a high accuracy and AUC
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  • - This study looked at how internet-based integrated care affects breastfeeding outcomes and emotional well-being in first-time mothers (primiparous women) who were treated at Baoji People's Hospital from July 2020 to September 2023.
  • - The researchers compared a group receiving internet-based care to a control group getting standard follow-up, finding that the internet care group had higher breastfeeding success rates and improved knowledge and confidence by six months postpartum.
  • - Key factors impacting breastfeeding included age, delivery method, and nipple condition as risks, while education level, job type, and frequent feeding helped support successful breastfeeding.
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  • Gerberae Piloselloidis Herba (GPH) has been shown to effectively treat allergic asthma, with specific components—luteolin, arbutin, and marmesin—demonstrating significant therapeutic potential, though their exact mechanism remains unclear.
  • In a study using an allergic asthma mouse model, treatment with the active component mixture and GPH resulted in decreased asthma symptoms, reduced inflammatory cell counts, and lower cytokine levels, alongside improvements in lung tissue health.
  • The mixture exhibited effects similar to dexamethasone and suppressed the PI3K/Akt signaling pathway, indicating its potential in modulating apoptotic processes in lung tissue, thereby alleviating allergic asthma symptoms.
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Myocardial fibrosis (MF) is a major cause of morbidity and mortality worldwide. Qili Qiangxin capsule (QLQX) is a traditional Chinese medicine (TCM) formula used for treating MF, QLQX can affect ventricular remodeling by regulating collagen deposition; however, the specific mechanism by which QLQX modulates collagen homeostasis remains unclear. Thus, this study aimed to explore the effect of QLQX on collagen fibers and its mechanism of action in rats after myocardial infarction (MI).

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Article Synopsis
  • The study examines the combined effects of sleep-related disorders (SRD) and hypertension (HTN) on cardiovascular disease (CVD), using data from the National Health and Nutrition Examination Survey (NHANES) involving over 33,000 participants.
  • Results show that both SRD (odds ratio (OR) = 1.90) and HTN (OR = 2.28) independently increase the risk of developing CVD, highlighting a significant association.
  • The research also identifies a significant interaction between SRD and HTN, suggesting that their combined presence increases the risk of CVD more than either condition alone, indicating that lifestyle management for both may be essential for heart health
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Hepatocellular carcinoma (HCC) tissue is rich in dendritic cells, T cells, B cells, macrophages, natural killer cells and cellular stroma. Together they form the tumor microenvironment (TME), which is also rich in numerous cytokines. Tumor‑associated macrophages (TAMs) are involved in the regulation of tumor development.

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Given the friction and drag reduction effects observed in various biological hexagonal structures in nature, a new design was implemented on the rubber surface of the stator of a submersible screw pump. This design featured a multilayer concentric hexagonal groove structure. Furthermore, a composite multilayer hexagonal structure integrating grooves and pits was also developed and applied.

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Conductive hydrogels, characterized by their unique features of flexibility, biocompatibility, electrical conductivity, and responsiveness to environmental stimuli, have emerged as promising materials for sensitive strain sensors. In this study, a facile strategy to prepare highly conductive hydrogels is reported. Through rational structural and synthetic design, silver nanowires (AgNWs) are incorporated into poly(N-acryloyl glycinamide) (PNAGA) hydrogels, achieving high electrical conductivity (up to 0.

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Autism spectrum disorder (ASD) is a general neurodevelopmental disease characterized by unusual social communication and rigid, repetitive behavior patterns. The purpose of this study was to investigate the effects of ASD on the alteration of neural oscillatory patterns and synaptic plasticity, which commonly supported a wide range of basic and higher memory activities. Accordingly, a prenatal valproic acid (VPA) exposure rat model was established for studying autism.

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