Publications by authors named "Chun-yiu Jack Cheng"
Article Synopsis
- * This study used a vertebral landmark extraction method and a Feedforward Neural Network (FNN) to predict scoliosis progression in 79 AIS patients, achieving a mean absolute error of 1.5 degrees in intervertebral angle progression and a strong correlation of 0.86 with predicted Cobb angles.
- * The FNN showed high accuracy (0.85) in classifying different Cobb angle ranges, indicating its potential for enhancing tailored treatments, although addressing issues like over-fitting could further improve results.
Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity that is associated with low bone mineral density (BMD). Vitamin D (Vit-D) supplementation has been suggested to improve BMD in AIS, and its outcomes may be related to genetic factors. The present study aimed to (a) investigate the synergistic effect between a low BMD-related gene (wingless-related integration site 16, ) and two important Vit-D pathway genes (Vit-D receptor, and Vit-D binding protein, ) on serum Vit-D and bone qualities in Chinese AIS patients and healthy adolescents, and (b) to further investigate the effect of ablating on the cortical bone quality and whether diets with different dosages of Vit-D would further influence bone quality during the rapid growth phase in mice in the absence of .
View Article and Find Full Text PDFObjective: To investigate the microstructure of trabecular bone in adolescent idiopathic scoliosis (AIS) and age-matched congenital scoliosis (CS), and to evaluate the bone mineral status of CS patients compared with normal controls and AIS patients.
Methods: This study included 15 AIS and 16 CS female patients and 35 healthy female adolescents. Corrective surgery was indicated for the AIS and CS patients, from whom iliac crest biopsies were collected during autograft harvesting, and scanned by micro-computer tomography.
Objective: To evaluate the trabecular bone micro-structure from different sites of spine in adolescent idiopathic scoliosis patients. The target site consisted of the bilateral facet joints from apical vertebrae and from end vertebrae.
Methods: Nine AIS patients with mean age 14.