Publications by authors named "Chun-yan Li"

Thunb. (1784) is primarily distributed in eastern Asia,  has a total length of 152,778 bp and consists of a large single copy (LSC) region of 84,517 bp, a small single copy (SSC) region of 18,277 bp, and two inverted repeat (IRs) regions of 24,992 bp . The GC content is 37.

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, widely distributed in China, has a 152,467 bp chloroplast genome with a large single-copy (LSC) region of 83,473 bp, a small single-copy (SSC) region of 18,594 bp, a pair of inverted repeat regions (IRs) of 25,194 bp in length. The GC content is 36.46%.

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Article Synopsis
  • The study introduces a novel near-infrared (NIR) fluorescent probe designed for precise tumor localization and surgical navigation, improving outcomes in cancer surgeries.
  • This probe targets hepatocellular carcinoma cells and shows a significant emission shift in response to the enzyme γ-glutamyltranspeptidase (GGT), enhancing early cancer diagnosis and surgical imaging.
  • With its ability to detect tumors accurately and provide real-time imaging guidance during surgeries, this probe holds potential for improved surgical precision and patient outcomes in clinical settings.
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Ulcerative colitis (UC) is an inflammatory disease that leads to the overexpression of peroxynitrite (ONOO). Up to now, it has been a challenge to design a colon-targeted fluorescent probe with a large emission shift that can detect and image ONOO in UC mice. Here, a fluorophore (pyran-coumarin) is linked with cholic acid to develop a colon-targeted fluorescent probe () for the detection of ONOO.

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The high heterogeneity within and between breast cancer patients complicates treatment determination and prognosis assessment. Treatment decision-making is influenced by various factors, such as tumor subtype, histological grade, and genotype, necessitating personalized treatment strategies. Prognostic outcomes vary significantly depending on patient-specific conditions.

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The combination of chemotherapy and photodynamic therapy holds immense potential for achieving synergistic anti-tumor efficacy. However, challenges such as poor stability and premature drug release prior to reaching tumor sites impede the widespread application of this synergistic therapeutic approach. In this study, a novel ATP-responsive NIR fluorescence nanosystem (CDZ) for imaging-guided chemotherapy and PDT has been developed.

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Cancer, a pressing global health challenge, is characterized by its rapid onset and high mortality rates. Conventional treatment methods prove insufficient in achieving the desired therapeutic outcomes, underscoring the critical need to identify an effective and safe approach for cancer treatment. In this study, a copper-doped nanoparticle known as Cu-DOX@ZIF-90 is designed by incorporating copper(II) (Cu(II)) and encapsulating doxorubicin (DOX) within ZIF-90.

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A novel lactic acid bacterial strain (designated N163-3-2), isolated from traditional Chinese pickle ('Suan cai'), was characterized using a polyphasic approach. Strain N163-3-2 was most closely related to the type strains of Lacticaseibacillus baoqingensis, Lacticaseibacillus manihotivorans, and Lacticaseibacillus porcinae, having 97.9-98.

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Four Gram-stain-positive bacterial strains (designated 475-2, 46-6B, 778-2 and A810-3), isolated from traditional Chinese pickle, were characterized using a polyphasic taxonomic approach. Strain 475-2 was most closely related to the type strain of Lapidilactobacillus achengensis, having 99.9% 16S rRNA gene sequence similarity, 94.

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Ram sperm undergo a sequence of physiological and biochemical changes collectively termed as capacitation to perform oocyte fertilization. However, the protein changes induced by capacitation remain in need of further exploration. Thus, the present study investigated the comparative proteomic profiling in ram spermatozoa under non-capacitating (NC) and capacitating (CAP) conditions in vitro using a liquid chromatography-tandem mass spectrometry combined with tandem mass tag labeling strategy.

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Objective: To explore the effectiveness of a nutritional intervention in rescuers who screened positive for depression.

Methods: A randomized controlled trial design was employed. From June to August, 2022, 4,460 rescuers were screened using the Self-Rating Depression Scale (SDS), and 1,615 positive cases were identified.

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Although precise regulation of the crystalline structures of metal oxides is an effective method to improve their antibacterial activities, the corresponding mechanisms involved in this process are still unclear. In this study, three kinds of cuprous oxide (CuO) samples with different structures of cubes, octahedra, and rhombic dodecahedra (c-CuO, o-CuO, and r-CuO) have been successfully synthesized and their antibacterial activities are compared. The antibacterial activities follow the order of r-CuO > o-CuO > c-CuO, revealing the significant dependence of the antibacterial activities on the crystalline structures of CuO.

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Food safety is a serious issue worldwide and practical detection method is vital for the supervision of food safety. It is necessary to establish efficient and economical methods to detect antibiotics, especially antibiotics in complex systems. This study employs citric acid and m-phenylenediamine to synthesize N, P-codoped carbon dots (N, P-CDs) by a microwave-assisted method.

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The spatio-temporal variation characteristics and potential sources of carbonaceous aerosols in the Guanzhong Plain during the Spring Festival in 2023 were analyzed using inverse distance weighting spatial interpolation (IDW), secondary organic carbon (SOC) estimation, and potential source contribution factor analysis (PSCF), with the OC and EC in the PM of five cities: Xi'an, Baoji, Xianyang, Weinan, and Tongchuan as the research objects. The results showed that in terms of time distribution, (OC) was as follows: after the Spring Festival [(18.6 ±11.

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Article Synopsis
  • Psychological issues like anxiety and depression worsen symptoms and quality of life in COPD patients, making it essential to study comprehensive assessments in treating these conditions in the elderly.
  • The study compares two groups of COPD patients—one receiving routine care and the other receiving comprehensive assessments—looking at their symptoms, quality of life, and psychological factors.
  • Results show that the group receiving comprehensive assessments had improved quality of life and lower anxiety and depression scores compared to the control group, demonstrating the effectiveness of this approach in COPD care.
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Background: Glutathione (GSH), a highly abundant thiol compound within cells, plays a critical role in physiological processes and exhibits close correlation with cancer. Among molecular imaging technologies, most probes have relatively short emission wavelengths and lack photoacoustic imaging (PA) capability, resulting in the inability to obtain tissue images with high penetration depth. The presence of GSH in the tumor microenvironment neutralizes ROS, diminishing the therapeutic effect of PDT, thus resulting in often unsatisfactory therapeutic efficacy.

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A near-infrared fluorescent probe (TX-P) for detecting peroxynitrite is constructed. The probe has a near-infrared emission (725 nm), large Stokes shift (125 nm) and excellent sensitivity and selectivity. In addition, TX-P can be used to visualize ONOO in living cells, image ONOO in paw edema mice and evaluate anti-inflammatory drugs.

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Nitroreductase (NTR) overexpression often occurs in tumors, highlighting the significance of effective NTR detection. Despite the utilization of various optical methods for this purpose, the absence of an efficient tumor-targeting optical probe for NTR detection remains a challenge. In this research, a novel tumor-targeting probe (Cy-Bio-NO) is developed to perform dual-modal NTR detection using near-infrared fluorescence and photoacoustic techniques.

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Three Gram-stain-positive bacterial strains were isolated from traditional Chinese pickle and characterized using a polyphasic taxonomic approach. Results of 16S rRNA gene sequence analysis indicated that strain 74-4 was most closely related to the type strains of Lacticaseibacillus suibinensis and Lacticaseibacillus suilingensis, having 99.9% and 100% 16S rRNA gene sequence similarities, respectively, and that strains 419-1.

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Fatty liver disease affects at least 25 percent of the population worldwide and is a severe metabolic syndrome. Viscosity is closely related to fatty liver disease, so it is urgent to develop an effective tool for monitoring viscosity. Herein, a NIR fluorescent probe called MBC-V is developed for imaging viscosity, consisting of dimethylaniline and malonitrile-benzopyran.

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In 2018, Nouioui et al. proposed that Bifidobacterium coryneforme was a later synonym of Bifidobacterium indicum on the basis of the digital DNA-DNA hybridization (dDDH) value (85.0%) between B.

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A novel bifidobacterium (designated F753-1) was isolated from the gut of honeybee (). Strain F753-1 was characterized using a polyphasic taxonomic approach. Strain F753-1 was phylogenetically related to the type strains of , , , , and , having 98.

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Article Synopsis
  • Minimally invasive surgery uses advanced tools to treat issues in the body with smaller incisions, achieving similar outcomes to traditional surgery while reducing trauma and recovery time.
  • It is particularly beneficial for gastric cancer patients, offering options like endoscopic mucosal resection and laparoscopic techniques, which minimize blood loss and psychological stress.
  • Innovations in these techniques, such as band-assisted EMR and closed LECS, enhance precision and effectiveness for various stages of early gastric cancer treatment.
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