Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives.

A series of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives were synthesized. The results showed that compounds 9q and 10q can strongly inhibit Staphylococcus aureus DNA gyrase and Bacillus subtilis DNA gyrase (with IC(50s) of 0.125 and 0.

Comparative enantioseparation of seven triazole fungicides on (S,S)-Whelk O1 and four different cellulose derivative columns.

The comparative enantioseparation of seven chiral triazole fungicides on a Pirkle type (S,S)-Whelk O1 chiral column and four different cellulose derivative columns, namely cellulose tribenzoate (CTB), cellulose tris(4-methylbenzoate) (CTMB), cellulose triphenylcarbamate (CTPC), and cellulose tris(3,5-dimethylphenyl carbamate) (CDMPC), in normal phase mode is described. The seven triazole fungicides investigated were tebuconazole, hexaconazole, myclobutanil, diniconazole, uniconazole, paclobutrazol, and triadimenol. The chiral separation of each solute was investigated with ethanol, n-propanol, iso-propanol, and n-butanol, respectively, as polar modifier in the hexane mobile phase.

Separation and identification of cis and trans isomers of 2-butene-1,4-diol and lafutidine by HPLC and LC-MS.

The cis and trans isomers separation of 2-butene-1,4-diol and lafutidine were studied by HPLC on two kinds of chiral columns: (S,S)-Whelk-O 1 and ChiraSpher. The isomers of 2-butene-1,4-diol can be separated on both chiral columns while the isomers of lafutidine can only be resolved on ChiraSpher column. The influence of different type and amount of mobile phase modifier on the isomers separation was extensively studied.