Publications by authors named "Chun-ting Qi"
Article Synopsis
- Receptor tyrosine kinases (RTKs) are important in cancer development, particularly in clear cell renal cell carcinoma (ccRCC), which makes up 75% of renal cell cancers; however, their activation and function in ccRCC were not fully understood before this study.* -
- The study analyzed RTK phosphorylation in ccRCC patient samples and established xenograft models in mice, revealing that ccRCC samples had distinct RTK phosphorylation patterns compared to cell lines and normal tissues, with 9 specific RTKs identified.* -
- Treatment with RTK inhibitors in the xenograft models effectively blocked tumor growth and signaling pathways, indicating that the phosphorylation patterns of RTKs in ccRCC are
Aim: To investigate the active constituents of Lignum Sappan (Caesalpinia sappan L.) on growth-related signaling and cell mitosis.
Method: The influence of the ethyl acetate (EtOAc) extract of Lignum Sappan and its constituents on growth-related signaling were evaluated by a luciferase assay in cells stably-transfected with NF-κB, STAT1, or STAT3 responsive luciferase reporter plasmid.
Aim: To examine the effect of GNTI [5'-guanidinyl-17-(cyclopropylmethyl)-6,7- dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan], a selective antagonist for the kappa opioid receptor, in the MK-801 (dizocilpine maleate)-induced behavioral model of psychosis in schizophrenia as a way to explore the involvement of the kappa opioid receptor in modulating psychotic symptoms of schizophrenia.
Methods: Two doses of MK-801 (0.3 mg/kg and 0.