Pathological and metabolic alterations co-exist and co-develop in the progression of chronic pancreatitis (CP). The aim of the present study was to investigate the metabolic characteristics and disease severity of a rat model of CP in order to determine associations in the observed pathology and the metabolites of CP using high-resolution magic-angle spinning nuclear magnetic resonance spectroscopy (HR-MAS NMR). Wistar rats (n=36) were randomly assigned into 6 groups (n=6 per group).
View Article and Find Full Text PDFBackground: To investigate the monoexponential and biexponential apparent diffusion parameters in different anatomical regions of the healthy pancreas using intravoxel incoherent motion (IVIM) diffusion weighted imaging (DWI).
Methods: Fifty-seven healthy volunteers (age, 45.0 ± 10.
The etiology and pathogenesis of pancreatitis remains unclear. In the presence of pancreatic inflammation, metabolite abnormalities appear before transformation of tissue structure and changes in functions occur. Detection of abnormalities in metabolite levels facilitates a greater understanding of the pathophysiological events and aids in the early diagnosis of the disease.
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