Publications by authors named "Chun-lian Liang"
Article Synopsis
- Idiopathic pulmonary fibrosis (IPF) is a serious lung disease with a high death rate; the adapter protein Disabled-2 (DAB2) plays a role in cell adhesion and is differentially expressed in fibrotic lungs.
- In a mouse model of pulmonary fibrosis induced by bleomycin, DAB2 levels increased in fibrotic tissue, and its co-localization with α-smooth muscle actin indicated a role in fibrosis progression.
- The study highlights DAB2's involvement in the activation of the IGF-1R/PI3K/Akt signaling pathway, suggesting it may be crucial for understanding and potentially targeting IPF mechanisms.
Hyperglycemia is a major factor in vascular endothelial injury that finally leads to a cardiovascular event. Steroid receptor coactivators (SRCs) are a group of non-DNA binding proteins that induce structural changes in steroid receptors (nuclear receptors) critical for transcriptional activation. SRCs, namely, SRC-1, SRC-2, and SRC-3, are implicated in the regulation of vascular homeostasis.
View Article and Find Full Text PDF[Significance and effect of Glucosidorum Tripterygii tororum on expressions of Foxp3 in regulatory T cells in type 1 diabetic rat model].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
March 2008
Aim: To investigate the significance and effect of Glucosidorum Tripterygii tororum (GTT) on the expressions of Foxp3 in CD4(+)CD25(+) regulatory T cells (Tr) in type 1 diabetic rat model.
Methods: 48 rats were divided evenly into 3 groups by random. Diabetic model was developed by multiple low dose intraperitoneal injection of streptozotocin in group II, III, and group I was treated as normal control.