Role of infection in chronic obstructive pulmonary disease progression in an immunosuppressed rat pneumonia model.

, an opportunistic fungal pathogen, is the primary cause of pneumonia (PCP), which affects immunocompromised individuals and leads to high morbidity and mortality. colonization is associated with development of chronic obstructive pulmonary disease (COPD) in patients with HIV infection, and also non-sufferers, and in primate models of HIV infection. However, the mechanisms underlying infection in the pathogenesis of COPD have yet to be fully elucidated.

[Study on pathogenicity of and its association with development of chronic obstructive pulmonary disease].

Objective: To investigate the pathogenicity of and its association with the development of chronic obstructive pulmonary disease (COPD).

Methods: The rat model of pneumonia (PCP) was induced by intraperitoneal injection with dexamethasone, which was confirmed by pathogenic detection. The pathologic changes of rat lung specimens were examined using conventional HE staining, and the expression of inflammatory cells were detected by flow cytometry in bron-choalveolar lavage fluid (BALF) and splenic tissues of the rat model of PCP.

Genotyping of Pneumocystis jirovecii by Use of a New Simplified Nomenclature System Based on the Internal Transcribed Spacer Regions and 5.8S rRNA Gene of the rRNA Operon.

Genotyping based on internal transcribed spacer 1 (ITS1) and ITS2 of the rRNA operon has played an important role in understanding the transmission and epidemiology of , one of the major opportunistic pathogens in individuals with AIDS and other immunocompromised individuals. The widespread use of this typing system has resulted in several problems, including inconsistent genotype nomenclatures, difficult data transferability, and complicated interpretation of the length variation in multiple homopolymeric tracts. The aim of this study was to establish a new, simplified genotype nomenclature system for based on the ITS1 and ITS2 sequences.

Synthetic p55 tandem DNA vaccine against Pneumocystis carinii in rats.

Pneumocystis spp. are opportunistic fungal pathogens that are closely associated with severe pneumonia and pulmonary complications in patients with impaired immunity. In this study, the antigenic epitopes of the gene encoding the 55 kDa antigen fragment of Pneumocystis (p55), which may play an important role in Pneumocystis pneumonia, were analyzed.

Investigation of Pneumocystis jirovecii colonization in patients with chronic pulmonary diseases in the People's Republic of China.

Background: The detection of Pneumocystis jirovecii DNA in respiratory specimen from individuals who do not have signs or symptoms of pneumonia has been defined as colonization. The role of P. jirovecii colonization in the development or progression of various lung diseases has been reported, but little information about P.

Clinical experience of individual surgical therapy in hypertensive basal ganglia hemorrhage.

Background: The aim of this article is to summarize the clinical experience stemming from the administration of different surgical therapies in hypertensive basal ganglia hemorrhage (HBGH) patients.

Methods: A series of 87 patients with HBGH who had received surgical therapy individually were enrolled in this study. The surgical therapies were stereotactic aspiration (SA), stereotactic aspiration plus fibrinolytic therapy (SA+F) and microsurgery with small bone window (MS), respectively.

Mini-Review of Published Reports on Coccidioidomycosis in China.

Coccidioidomycosis is a deep mycotic infection endemic to Americas. Although it has also been reported to occur in non-endemic areas, it has rarely been reported in China. We reviewed the literature on case reports of coccidioidomycosis in China from 1958 to 2015.

A pediatric case report and literature review of thelaziosis in China.

Thelaziosis is a zoonosis with regional epidemics, mainly present in oriental countries, with a majority of cases reported from China. We report a pediatric case of thelaziosis and present a literature review of Chinese case reports. The epidemiological features and clinical characteristics of thelaziosis in China are presented.

Emergency microsurgery for aneurysmal subarachnoid hemorrhage coexisting with brain hernia.

Aim: This work aims to summarize the experience in emergency microsurgery for patients with aneurysmal subarachnoid hemorrhage (SAH) that coexisted with brain hernia.

Material And Methods: A total of 26 patients with aneurysmal SAH complicated by brain hernia were subjected to emergency aneurysm clamping + decompressive craniectomy. 10 patients were diagnosed with aneurysmal SAH coexisted with brain hernia before operation.

Two cases of human thelaziasis as confirmed by mitochondrial cox1 sequencing in China.

Two special cases of human thelaziasis were reported in China: an old farmer with heavy infection by 36 worms and a 7-year-old boy with infection by eight worms. Thelazia callipaeda was morphologically identified and confirmed by mitochondrial cox1 gene sequencing.

Trichuriasis diagnosed by colonoscopy: case report and review of the literature spanning 22 years in mainland China.

Trichuriasis is soil-source parasitic disease, usually endemic in warm, humid, tropical and subtropical countries. We report a case of trichuriasis diagnosed by colonoscopy performed in a non-endemic area and review the literature on the colonoscopic diagnosis of Trichuris trichiura spanning 22 years (1989-2011) in mainland China. A total of 4382 trichuriasis cases were diagnosed by colonoscopy out of 41,337 patients who underwent colonoscopy.

[Allele genotype analysis of Plasmodium vivax merozoite surface protein 1 (PvMSP-1) from Dangdong, Liaoning Province].

Nested PCR method was used to amplify the Plasmodium vivax merozoite surface protein 1 (PvMSP-1) gene fragment containing the ICB5 and ICB6 region from Plasmodium vivax in Liaoning Province. The PCR products were digested by Pvu II restriction endonuclease and the digested fragments were observed by 1.5% agarose gel electrophoresis, and all followed by sequencing analysis and comparison.

Retrospective study of Pneumocystis pneumonia over half a century in mainland China.

A retrospective study was performed on case reports of Pneumocystis pneumonia (PCP) from 1959 to 2009 in mainland China. The epidemiological characteristics of PCP over half a century were investigated over two time spans. The first was from 1959, when the first incidence of PCP was reported, to 1984, before the emergence of AIDS in mainland China.

[Progress on molecular biology of Pneumocystis--for hundred years since its discovery].

2009 marks the 100th anniversary of the first description of Pneumocystis, an organism that was initially classified as a protozoan and later in 1988, was phylogenetically reclassified in the fungal kingdom. The organism was ignored for its first 50 years but that has subsequently been recognized as an important pathogen in immunocompromised patients, especially patients with acquired immune deficiency syndrome(AIDS). This paper reviewed recent progress on the molecular biology, involving in the life cycle and metabolism of the organism.

Exposure of immunocompetent adult mice to Pneumocystis carinii f. sp. muris by cohousing: growth of P. carinii f. sp. muris and host immune response.

There has been emerging evidence that immunocompetent hosts can harbor Pneumocystis in their lungs. The purpose of this study was to determine the kinetics of Pneumocystis carinii f. sp.

[Susceptibility and immune responses to Pneumocystis carinii infection in different strains of mice by contagious transmission].

Objective: To explore the susceptibility of different strains of mice to P. carinii infection and the host immune response to the organism.

Methods: C57BL/6 and BALB/c strains of mice (15 each) were exposed to SCID mice infected with P.