Publications by authors named "Chun-kang Yang"
Objective: To compare neoadjuvant chemotherapy (nCT) with CAPOX alone versus neoadjuvant chemoradiotherapy (nCRT) with capecitabine in locally advanced rectal cancer (LARC) with uninvolved mesorectal fascia (MRF).
Background Data: nCRT is associated with higher surgical complications, worse long-term functional outcomes, and questionable survival benefits. Comparatively, nCT alone seems a promising alternative treatment in lower-risk LARC patients with uninvolved MRF.
Article Synopsis
- A study was conducted to compare the short-term effectiveness of laparoscopic surgery versus open surgery for treating low rectal cancer, involving 1,070 patients randomized across 22 hospitals in China.
- The results showed similar rates of complete mesorectal excision between the two techniques, with minor differences in the rates of negative margins and lymph nodes retrieved.
- Overall, the findings indicate that laparoscopic surgery may have comparable outcomes to open surgery for low rectal cancer, but the differences in measures like sphincter preservation were not detailed.
Background: To investigate thymidine kinase 1(TK-1) and Ki67 expression levels of human colorectal carcinoma cells line SW480 after exposure to a simulated laparoscopic carbon dioxide (CO2) pneumoperitoneum environment at different pressures and lengths of exposure time.
Methods: The effects of the simulated laparoscopic CO2 pneumoperitoneum environment at different CO2 pressures (6, 9, 12, and 15 mmHg) and exposure times (2 and 4 h) on TK-1 and Ki67 of SW480 cells were assessed by flow cytometry and reverse transcription (RT-PCR). Cells cultured in a standard environment were used as the control group (at 37 °C, 5% CO2).
Background: The ability of pneumoperitoneum in laparoscopic surgery to promote proliferation and metastasis of colorectal cancer has become a focus of research in the field of minimally invasive surgery. The aim of this research was to investigate the effect of CO2 pneumoperitoneum under different pressures and exposed times on the expression of chemokine receptors in colorectal carcinoma cells.
Methods: We constructed an in vitro pneumoperitoneum model.
Recent evidence suggests the involvement of γ-synuclein in tumorigenesis and tumor progression. The present study was designed to further clarify the effects of γ-synuclein on the biological features of colon cancer cells in vitro and in vivo. We constructed the eukaryotic expression vector and siRNA vector and selected stable transfectants to respectively upregulate and downregulate γ-synuclein expression in SW1116 cells.
View Article and Find Full Text PDF[Clinical characteristics, diagnosis and treatment of hepatoid adenocarcinoma of the stomach].
Zhonghua Wei Chang Wai Ke Za Zhi
May 2007
Objective: To investigate the clinical characteristics,diagnosis and treatment of hepatoid adenocarcinoma of the stomach.
Methods: Clinical data of 13 hepatoid adenocarcinomas of the stomach, collected from 201 cases of gastric cancer, were analyzed retrospectively.
Results: Of the 201 gastric carcinomas, there were 13 AFP-producing adenocarcinomas of the stomach, the positive rate was 6.