Selenium inhibits high glucose- and high insulin-induced adhesion molecule expression in vascular endothelial cells.

Background: Initiation of an atherosclerotic lesion requires endothelial expression of adhesion molecules. Selenium (Se), a biologically essential trace element, can inhibit cytokine (e.g.

[The mechanism and implication of costimulatory molecules in dendritic cells in the development of asthma].

Objective: To exploring the role of costimulatory molecules in the development of asthma and its mechanisms.

Methods: Murine asthma model was established with ovalbumin (OVA) sensitization and challenge, and the model was confirmed by histological analysis of lung tissues, cell numbers and differentiations of bronchoalveolar lavage, serum OVA-specific IgE level and interleukin (IL)-4 and IL-5 production by splenic T cells. The purity of spleen-derived dendritic cells was assayed with fluorescein-actived cell sorter (FACS) by analyzing CD(11c) molecule.