[An epidemiologic study on functional constipation among adult communities in Shanghai].

Objective: To determine the prevalence and risk factors of functional constipation (FC) by using Rome III criteria in the local adult communities.

Methods: A stratified randomized and community-based study by multi-stage cluster sampling was employed. A household survey was conducted from April to May 2010.

The efficacy of Combizym in the treatment of Chinese patients with dyspepsia: a multicenter, randomized, placebo-controlled and cross-over study: Shanghai Combizym Clinical Cooperative Group.

Objective: To evaluate the efficacy and safety of Combizym treatment in Chinese patients with dyspepsia.

Methods: In this multicenter, randomized, placebo-controlled cross-over study, a total of 151 patients (76 men and 75 women, mean age: 44.67 +/- 6.

[Risk factors of irritable bowel syndrome in adolescents in China].

Objective: To explore the risk factors for irritable bowel syndrome (IBS) among school adolescents in China.

Method: A stratified, randomized study by cluster sampling was conducted, which recruited 51,956 students from high and primary schools in Chinese cities. All students were requested to fill in a questionnaire.

[Effects of silencing connective tissue growth factor on rat transforming growth factor beta/Smads signal].

Objective: To investigate the effects of small interfering RNA targeting connective tissue growth factor (CTGF) on rat transforming growth factor beta (TGF beta)/Smads signal pathway.

Methods: Chemically synthetic siRNA targeting CTGF was transfected into HSC T6 and then they were injected into rat livers through their intraportal veins. At the same time these rats also received CCl4 subcutaneously every three days for 6 consecutive weeks.

[An epidemiologic study of irritable bowel syndrome among adolescents in China].

Objective: To explore the prevalence of irritable bowel syndrome (IBS) and its distribution characteristics among adolescents in China.

Methods: A stratified and randomized study by cluster sampling was employed, the study recruited 51 956 students from high and primary schools in different Chinese cities. All students were requested to fill in a questionnaire.

Suppressive effects of 17beta-estradiol on hepatic fibrosis in CCl4-induced rat model.

Aim: To investigate the pathway via which 17beta-estradiol (beta-Est) exerts suppressive effects on rat hepatic fibrosis.

Methods: In vivo study was done in CCl4-induced female hepatofibrotic rats. Fibrosis-suppressive effect of beta-Est (20 microg/kg/d) was evaluated in intact and ovariectomized rat models.