The association between type 1 diabetes mellitus and the risk of immunoglobulin A nephropathy: a Mendelian randomization study.

Objective: To investigate the potential causal relationship between type 1 diabetes mellitus (T1DM) and IgA nephropathy (IgAN) to deepen understanding of the association between these two conditions and to provide a scientific basis for future preventive and therapeutic strategies.

Methods: This study employed Mendelian randomization (MR) analysis, using single nucleotide polymorphisms (SNPs) derived from genome-wide association studies (GWAS) as genetic instrumental variables (IVs), to assess the association between T1DM and IgAN. The analytical approaches included univariable and multivariable MR, along with sensitivity analyses such as Mendelian randomization-Egger (MR-Egger) and Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO), to evaluate the impact of heterogeneity and pleiotropy.

[Spatiotemporal dynamics of forest cover and its response to climate change in Shandong Province, China during 2000-2022.].

Accurately capturing the spatiotemporal dynamics of regional forest cover and its response to climate change is of great significance for forest resource management and ecological environment protection. We used statistical methods such us linear regression and correlation analysis, as well as remote sensing change monitoring to investigate the spatiotemporal dynamics of forest cover and its response to climate change from 2000 to 2022 in Shandong Province based on MODIS VCF products and meteorological data. The results showed that the forest co-verage and forest area in Shandong Province increased from 43.

Regulating the Topologies and Photoresponsive Properties of Lanthanum-Organic Frameworks.

Metal-organic frameworks (MOFs) show potential application in many domains, in which photochromic MOFs (PMOFs) have received enormous attention. Researchers mainly utilize photoactive ligands to build PMOFs. Recently, the mixed electron donating and accepting ligands strategies have also been used to construct PMOFs driven by the electron transfer between nonphotochromic moieties.

The role of Interleukin-22 in severe acute pancreatitis.

Severe acute pancreatitis (SAP) begins with premature activation of enzymes, promoted by the immune system, triggering a potential systemic inflammatory response that leads to organ failure with increased mortality and a bleak prognosis. Interleukin-22 (IL-22) is a cytokine that may have a significant role in SAP. IL-22, a member of the IL-10 cytokine family, has garnered growing interest owing to its potential tissue-protective properties.

Two different autorefractors for vision screening in children and adolescents.

Aim: To compare the consistency of two autorefractors (Tianle RM-9000 and Topcon KR-800) for school-age myopia children, and to provide a basis for largescale data analysis and comparison.

Methods: The refractive error in 909 subjects (age 4-18y) were measured using both autorefractors without cycloplegia. The data were analyzed using Fourier decomposition and the correlation coefficients, intraclass correlation coefficients (ICC), and Bland-Altman limits of agreement (LoA) for each parameter were calculated.

A biomarker panel of C-reactive protein, procalcitonin and serum amyloid A is a predictor of sepsis in severe trauma patients.

Severe trauma could induce sepsis due to the loss of control of the infection, which may eventually lead to death. Accurate and timely diagnosis of sepsis with severe trauma remains challenging both for clinician and laboratory. Combinations of markers, as opposed to single ones, may improve diagnosis.

Assessing the phylogenetic relationship among varieties of (Meliaceae) in sympatry with chloroplast genomes.

is an endangered species due to over-cutting and low natural regeneration in China. Its genetic conservation is of an increasing concern. However, several varieties are recognized according to the leaf and flower traits, which complicates genetic conservation of .

The experience of diabetic retinopathy patients during hospital-to-home full-cycle care: A qualitative study.

Background: Diabetic retinopathy (DR) is one of the major blinding eye diseases worldwide. Psychological, emotional and social problems of DR patients are prominent. The aim of this study is to explore the experiences of patients with different phases of DR from hospital to home based on the "Timing It Right" framework, and to provide a reference for formulating corresponding intervention strategies.

Reduced Graphene Oxide Derived from Low-Grade Coal for High-Performance Flexible Supercapacitors with Ultrahigh Cyclability.

Preparation of reduced graphene oxide (RGO) from abundant and inexpensive low-grade coal is regarded as one of the most promising methods for utilizing this resource in a high-value and environmentally sustainable manner. As the main precursor for the fabrication of RGO, graphene oxide (GO) can be extracted from low-grade coal such as lignite, but its size is just in the range of tens to hundreds of nanometers, which limits its practical application. Herein, we demonstrate that large-size RGO sheets can be prepared in large quantities by the pretreatment of lignite using the high temperature-high pressure (HTHP) method.

Label recovery and label correlation co-learning for multi-view multi-label classification with incomplete labels.

Multi-view multi-label learning (MVML) is an important paradigm in machine learning, where each instance is represented by several heterogeneous views and associated with a set of class labels. However, label incompleteness and the ignorance of both the relationships among views and the correlations among labels will cause performance degradation in MVML algorithms. Accordingly, a novel method, - - (MV2ML), is proposed in this paper.

Effects of dietary supplementation with N-carbamylglutamate on maternal endometrium and fetal development during early pregnancy in Inner Mongolia white cashmere goats.

This study investigated the effects of dietary supplementation with N-carbamylglutamate (NCG) on maternal endometrium and fetal development during early pregnancy of Inner Mongolia white cashmere goats. Forty-eight pregnant Inner Mongolia white cashmere goats (average age 3 years old, average lactation parity 2, and average body weight 43.81 ± 2.

[Differences in the tolerance and accumulation of arsenate in the consortia with various proportions of and ].

We constructed consortia of and with various alga-bacterium ratios (1:0, 1:1, 1:2, 1:3, 1:4). After being treated with arsenate [As(Ⅴ)] for 7 d, we measured the growth, As accumulation, adsorption and absorption, and As speciation transformation of consortia. Results showed that the chlorophyll content, dry weight, and specific growth rate of the symbiont increased significantly with increasing ratio after the As(Ⅴ) treatment, being 1.

Flavonoids in myocardial ischemia-reperfusion injury: Therapeutic effects and mechanisms.

Ischemic heart diseases are one of the major causes of death worldwide. Effective restoration of blood flow can significantly improve patients' quality of life and reduce mortality. However, reperfusion injury cannot be ignored.

Identifying Acetylation Protein by Fusing Its PseAAC and Functional Domain Annotation.

Acetylation is one of post-translational modification (PTM), which often reacts with acetic acid and brings an acetyl radical to an organic compound. It is helpful to identify acetylation protein correctly for understanding the mechanism of acetylation in biological systems. Although many acetylation sites have been identified by high throughput experimental studies via mass spectrometry, there still are lots of acetylation sites need to be discovered.

Effects of photoperiod on circadian clock genes in skin contribute to the regulation of hair follicle cycling of Inner Mongolia white cashmere goats.

This study investigated how the effects of photoperiod on circadian clock genes in the skin contribute to the regulation of hair follicle cycling of Inner Mongolia white cashmere goats. Twenty-four female (non-pregnant) Inner Mongolia white cashmere goats aged 1 - 1.5 years old with similar live weights (mean, 20.

Photo-controlled reversible secondary self-assembly of supramolecular nanosheets and their drug delivery behavior.

Supramolecular nano-drug delivery systems with stimuli-responsive features have attracted extensive attention in photodynamic therapy. In this work, a new kind of photo-controlled reversible two dimensional (2D) nanosheet was constructed by cucurbit[8]uril (CB[8])-mediated ternary complexation with lanthanide complexes, azobenzene quaternary ammonium salt and sodium dodecyl sulfonate, which exhibited rapid morphological transformation and high drug loading capacities. The constructed supramolecular secondary self-assembly system has become a very promising candidate as a drug nanocarrier.

[Cell suspension examination versus histopathological technique in detecting sperm in the testis tissue of non-obstructive azoospermia patients undergoing testicular sperm aspiration].

Objective: To explore the clinical selection and application of cell suspension examination (CSE) or histopathological technique (HPT) in detecting sperm in the testis tissue obtained by testicular sperm aspiration (TESA) in patients with non-obstructive azoospermia (NOA).

Methods: Totally, 1 006 NOA patients underwent TESA and their testis tissues were subjected to CSE or HPT for sperm detection. Based on the results of CSE, the testicular tissue samples were divided into groups A (with sperm, n = 567) and B (without sperm, n = 439) and the results were compared with those of HPT.

Effects of photoperiod on nutrient digestibility, hair follicle activity and cashmere quality in Inner Mongolia white cashmere goats.

Objective: This study investigated the effects of photoperiod on nutrient digestibility, hair follicle (HF) activity and cashmere quality in Inner Mongolia white cashmere goats.

Methods: Twenty-four female (non-pregnant) Inner Mongolia white cashmere goats aged 1 to 1.5 years old with similar live weights (mean, 20.

[Effects of Seasonal Asymmetric Warming on Soil CO Release in Karst Region].

Seasonal asymmetric warming is one of the distinguishing features of global warming. However, if this feature is not considered in studying the effects of global changes on terrestrial ecosystems, it might probably cause misunderstanding of these studies. The releasing features of soil CO in Karst regions under various warming scenarios were simulated following a four-year continuous warming period using infrared radiators.

[Short-term Mechanism of Warming-induced Stability for Organic Carbon in the Karst Plateau Soil].

Elucidating the mechanisms of warming-induced stability for soil organic C is one of the keys for evaluating the tendency of soil C sources/sinks in projected global warming models. Organic C densities in soil, and soil physical and biochemical fractions, under different warming scenarios in the Karst Plateau were investigated following a 4-yr continuous warming using infrared radiators, density fractionation and acid hydrolysis. Six treatments were arranged: no warming (ambient temp, CK); symmetric warming (ambient+2.

[Level of serum inhibin B for predicting the results of testicular sperm extraction in azoospermia patients].

Objective: To investigate the value of serum inhibin B (InhB) in predicting the results of testicular sperm extraction (TESE) in patients with azoospermia.

Methods: This study included 191 cases of obstructive azoospermia (OA), 360 cases of nonobstructive azoospermia (NOA), and 100 male controls with normal semen parameters. According to whether sperm was found in TESE, the NOA patients were divided into a sperm-absence group (TESE－, n=127) and a sperm-presence group (TESE+, n=233).

[Clinical analysis of 15 851 children at risk of inherited metabolic diseases].

Objective: To explore the value of urine gas chromatography-mass spectrometry (GC-MS) in the screening of children at risk of inherited metabolic diseases (IMD), and to identify the disease spectrum of IMD and the clinical characteristics of children with IMD.

Methods: The clinical data of 15 851 children at risk of IMD who underwent urine GC-MS in the Tianjin Children's Hospital between February 2012 and December 2016 were retrospectively analyzed.

Results: In the 15 851 children, 5 793 (36.