Incorporating Circulating Plasma Interleukin-10 Enhanced Risk Predictability of Mortality in Acute Type A Aortic Dissection Surgery.

Background: Acute type A aortic dissection (TAAD) is a life-threatening cardiovascular emergency with a high mortality rate. The peri-operative factors influencing in-hospital mortality among surgically treated TAAD patients remain unclear. This study aimed to identify key peri-operative risk factors associated with in-hospital mortality.

TREM2 modulates macrophage pyroptosis and inflammatory responses to ameliorate aortic valve calcification.

Background: Calcific aortic valve disease (CAVD) leads to valve thickening and calcification. Valvular interstitial cells (VICs) play a crucial role in valve homeostasis and their differentiation into osteoblast-like cells is influenced by macrophages. Triggering receptor expressed on myeloid cells 2 (TREM2) is involved in lipid metabolism and inflammation, but its role in CAVD remains unclear.