Publications by authors named "Chun-Yu Han"

Article Synopsis
  • - The study focuses on Nevoid basal cell carcinoma syndrome (NBCCS), a rare condition linked to high rates of basal cell carcinoma, potentially caused by mutations in the PTCH1 gene.
  • - Researchers identified a new nonsense mutation in the PTCH1 gene in a mother and her daughter, both of whom also had ovarian mature teratomas.
  • - Treatment outcomes showed persistent issues for both individuals, underscoring the complex effects of the mutation and related health challenges.
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  • A study identified key genomic regions and genes related to soybean seed size and oil traits from 286 soybean accessions using various genetic analysis methods.
  • The research revealed 952 candidate domestication regions (CDRs) and 538 candidate improvement regions (CIRs), which were further integrated with previous research to identify a total of 1469 loci and 433 QTL clusters.
  • The study highlighted 7 domestication and 7 improvement genes linked to these traits, suggesting that trait changes are influenced by elite haplotypes, mutations, and expression factors, providing valuable insights for future soybean breeding efforts.
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Plant-associated microbes have been reported as important but overlooked drivers of plant-herbivorous insect interactions. Influence of plant-associated microbes on plant-insect interactions is diverse, including beneficial, detrimental, and neutral. Here, we determined the effects of three Penicillium fungi, including Penicillium citrinum, Penicillium sumatrense, and Penicillium digitatum, on the oviposition selection and behavior of the yellow peach moth (YPM), Conogethes punctiferalis (Guenée).

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Article Synopsis
  • Techniques for tracking RNAs in living cells have evolved, with recent advancements including fluorescent protein-labeled Cas9 and Cas13, although they struggle with background noise issues.
  • The study introduced a novel Cas6-based fluorescence complementation (Cas6FC) platform that detects target RNAs in vivo using a split-Venus system, resulting in minimal background noise.
  • Cas6FC is highly sensitive, requiring just a single copy of the target RNA's binding sequence to activate fluorescence, enhancing both the detection capabilities and preserving target RNA integrity.
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Background: Keratinized gingival insufficiency is a disease attributed to long-term tooth loss, can severely jeopardizes the long-term health of implants. A simple and effective augmentation surgery method should be urgently developed.

Case Summary: A healthy female patient, 45-year-old, requested implant restoration of the her left mandibular first molar and second molar.

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Unlabelled: Flowering time (FT) and plant height (PH) are important agronomic traits in soybean. However, their genetic foundations are not fully understood. Thus, in this study, a total of 106,013 single nucleotide polymorphisms in 286 soybean accessions were used to associate with the first and full FT (FT1 and FT2) and PH in 4 environments and their BLUP values using 6 multi-locus genome-wide association study methods.

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100-seed weight (100-SW) in soybeans is a yield component trait and controlled by multiple genes with different effects, but limited information is available for its quantitative trait nucleotides (QTNs) and candidate genes. To better understand the genetic architecture underlying the trait and improve the precision of marker-assisted selection, a total of 43,834 single nucleotide polymorphisms (SNPs) in 250 soybean accessions were used to identify significant QTNs for 100-SW in four environments and their BLUP values using six multi-locus and one single-locus genome-wide association study methods. As a result, a total of 218 significant QTNs were detected using multi-locus methods, whereas eight QTNs were identified by a single-locus method.

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Background: The single-nucleotide polymorphisms (SNPs) of apurinic/apyrimidinicendonuclease 1 (APE1), which has been implicated in cancers and the DNA base excision repair (BER) process, have not been thoroughly investigated in association with the risks of oxidative stress-related vitiligo.

Objectives: The aim of this study is to investigate associations between APE1 single-nucleotide polymorphisms 141T >G and 1349T >G and risk and prognosis of vitiligo.

Material And Methods: From June 2013 to June 2015, a total of 460 vitiligo patients were randomly recruited as a case group; 200 of these patients received narrow bound ultraviolet B (NB-UVB) treatment.

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Winter flooding events are common in some rivers and streams due to dam constructions, and flooding and waterlogging inhibit the growth of trees in riparian zones. This study investigated sex-specific morphological, physiological and ultrastructural responses to various durations of winter flooding and spring waterlogging stresses, and post-flooding recovery characteristics in Populus deltoides. There were no significant differences in the morphological, ultrastructural and the majority of physiological traits in trees subjected to medium and severe winter flooding stresses, suggesting that males and females of P.

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BEX2 (Brain expressed X-linked protein 2), a 13 kDa protein, is highly expressed in brain and testis. It is reported that the protein expression of BEX2 dramatically alters during the embryo development, but little is known about its function. By means of yeast two-hybrid screening, we isolated that INI1/hSNF5 was a binding partner for BEX2, a key component of SWI/SNF chromosome remolding complex.

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