Spontaneous Regression of Cervical Intraepithelial Neoplasia 2: A Meta-analysis.

Background: Cervical intraepithelial neoplasia (CIN) is a precancerous condition that, if progresses, can cause cervical cancer. Less severe forms such as CIN1 regress spontaneously for most of the cases, but for high-grade CIN (CIN2 or CIN3), have higher potentials for progression.

Objective: Aim of the present study was to obtain reliable estimates of spontaneous regression and progression rates of CIN2.

[Clonality detection of cervical cancer and cervical intraepithelial neoplasia by human androgen receptor gene analysis].

Objective: To assess the clonality of cervical cancer and cervical intraepithelial neoplasia (CIN) by the study of X-chromosome inactivation pattern with human androgen receptor gene (HUMARA) analysis.

Methods: Tissue DNA from samples of 26 invasive cervical cancers (9 in stage I, 10 in stage II and 7 in stage III), 31 CINs (12 CINI, 10 CIN II and 9 CIN III) and 33 normal cervixes was extracted, and then digested with methylation sensitive restriction endonuclease Hha I. HUMARA fragment was amplified with PCR method and PCR product was electrophoresed.