Publications by authors named "Chun-Shen Shen"
Background: Recent genome-wide association studies (GWAS) have identified genes or loci affecting lipid levels. Given the difference in allele frequencies and linkage disequilibrium patterns across the populations, a GWAS was conducted using the Illumina 550K in a Japanese population (n=900) in search of population-specific genetic variations associated with high-density lipoprotein (HDL)-cholesterol.
Methods And Results: Among the 368,274 single nucleotide polymorphisms (SNPs) with a minor allele frequency of at least 0.
The Dahl salt-sensitive (DS) rat is the most prevalently used animal model of salt-sensitive hypertension. The purpose of the present study was to test the hypothesis that mitochondrial DNA (mtDNA) polymorphisms influence blood pressure in DS rats. We produced two strains of female F1 rats, one from female DS and male Lewis rats (DL) and the other from Lewis female and DS male rats (LD).
View Article and Find Full Text PDFECA39 is a novel distant metastasis-related biomarker in colorectal cancer.
World J Gastroenterol
September 2006
Aim: To investigate the possible role of polysaccharide-K (PSK) -related markers in predicting distant metastasis and in the clinical outcome of colorectal cancer (CRC).
Methods: Firstly, we used protein microarrays to analyze the in vitro expression profiles of potential PSK-related markers in the human colorectal adenocarcinoma cell line SW480, which carries a mutant p53 gene. Then, we investigated the clinical implications of these markers in the prognosis of CRC patients.
Article Synopsis
- Psoriasis is a chronic skin disorder characterized by rapid skin cell production and inflammation, with little understanding of the mechanisms behind these changes.
- The p63 transcription factor, important for maintaining skin stem cells and linked to various skin conditions, was studied to see its role in psoriasis.
- The study found p63 is involved in early changes in psoriatic skin, showing increased activity in the thickened areas and suggesting its role in epidermal remodeling and the elongation of rete ridges.
Article Synopsis
- Keratinization is a specialized type of cell death (apoptosis) that helps form the outer layer of skin (stratum corneum) as keratinocytes die.
- Apoptosis in keratinocytes happens during normal skin development and in response to stressors like genetic issues or UVB exposure.
- The chapter outlines a method called nick-end labeling to detect DNA fragmentation, helping to identify apoptotic cells in skin samples.