Publications by authors named "Chun-Ming Zou"
Behav Brain Res
March 2022
Article Synopsis
- - This study investigates the antidepressant-like effects of Berberine (BBR), an alkaloid from the Chinese herb Huanglian, focusing on its influence on the kynurenine/serotonin pathway in a mouse model of depression.
- - The researchers established a chronic unpredictable mild stress model over 21 days and treated the mice with BBR in varying dosages alongside a control and fluoxetine (an established antidepressant), measuring behavioral changes and chemical levels in the hippocampus.
- - Results showed that BBR improved depressive symptoms by altering levels of key neurotransmitters and reducing the expression of enzymes associated with depression, such as IDO1 and MAOA, while enhancing those related to serotonin production.
