Publications by authors named "Chun-Ming Jia"
[Establishment and application of screening methods for non-agonist PPARγ ligand].
Yao Xue Xue Bao
December 2014
Article Synopsis
- Researchers developed in-vitro assay methods to assess how compounds interact with the peroxisome proliferator-activated receptor gamma (PPARγ), an important target for various metabolic disorders.
- They created specific plasmids for testing both the gene expression triggered by PPARγ and the binding activity of various compounds using a competitive binding assay technique called time-resolved fluorescence resonance energy transfer (TR-FRET).
- Among tested compounds, ZLJ01 was identified as having strong binding affinity to PPARγ without triggering gene activation, and it showed promise in enhancing insulin-stimulated glucose uptake in liver cells in preliminary tests.
This study aimed to analyze the effects and potential mechanisms of pioglitazone on triglyceride and cholesterol metabolism in obese diabetic KKAy mice. Pioglitazone was orally administered to KKAy mice over 30 days. Compared to C57BL/6J mice, KKAy mice developed obvious insulin resistance, hepatic steatosis, and hyperlipidemia.
View Article and Find Full Text PDF