[Study on Application of RVD Regimen Sequential Auto-HSCT in the Treatment of Multiple Myeloma Evaluated by Propensity Score Matching].

Objective: To investigate the application effect of sequential autologous hematopoietic stem cell transplantation (Auto-HSCT) with lenalidomide, bortezomib and dexamethasone (RVD) in the treatment of multiple myeloma (MM) evaluated by propensity score matching.

Methods: The clinical data of 49 MM patients treated with RVD scheme and followed-up for 36 months in the hospital from January 2015 to January 2021 were retrospectively analyzed and included in the control group, the clinical data of 54 MM patients who received RVD scheme and sequential Auto-HSCT scheme and completed 36 months of follow-up in the hospital during the same period were collected and included in the observation group. PSM method (1∶1, caliper value=0.

Potential effects of the nursing work environment on the work-family conflict in operating room nurses.

Background: The nursing working environment is an important subsystem in the hospital environment. A good working environment could have a positive impact on nurses. However, the work-family conflict and unsatisfactory working environment could significantly reduce their working enthusiasm, efficacy as well as the overall quality of the nursing, increase their fatigue, and thereby compromise their career status.

[Changes of Serum Gonadal Hormones Levels During Musk-secreting Period and Estrus of Moschus berezovskii].

Objective: To detect concentrations of serum gonadal hormones (testosterone, estradiol and progesterone) in musk-secreting period and estrus of Moschus berezovskii, and to study the association of serum gonadal hormones concentrations and musk-secreting.

Methods: The concentrations of serum gonadal hormones were detected with magnetic particle separation ELISA.

Results: During musk-secreting period, concentration changes of three serum gonadal hormones showed clear regularity, three crests occurred synchronously.

Clonal origin and evolution of myelodysplastic syndrome analyzed by dysplastic morphology and fluorescence in situ hybridization.

Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic stem/progenitor cells. As bone marrow cells are extremely diverse in these disorders, the origin and evolution of MDS clones are difficult to identify and trace. Cellular dysplasia is a distinct morphologic feature; however, whether the dysplastic cells represent abnormal clones or only nonspecific superficial phenomena remains to be clarified.

Development and validation of an rp-hplc method for simultaneous determination of Ramipril and Amlodipine in tablets.

An rp-hplc method for the simultaneous determination of Ramipril (RP) and Amlodipine (AL) in tablets was developed and validated by Chinese Pharmacopoeia 2010. The linearity of the proposed method was investigated in the range of 0.01-0.

[Study of the clonal origin and development of MDS by FISH analysis of dysplasia cells in bone marrow of patients with MDS].

This study was purpose to explore whether the dysplasia of myelodysplastic syndromes (MDS) is unspecific feature or results of the abnormal clone, and to provide the evaluation of abnormal clone changes in bone marrow cells of MDS patients. The dysplasia cells in bone marrow smears was analyzed by morphologic observation, the clonal origin and development in 16 cases of MDS with abnormality of chromosome karyotypes were investigated by FISH combined with morphologic observation. The results found that both the dysplastic and nondysplastic bone cells displayed abnormal clones in the erythroid and granulocytic cells.

Growth and differentiation effects of Homer3 on a leukemia cell line.

The Homer protein family, also known as the family of cytoplasmic scaffolding proteins, which include three subtypes (Homer1, Homer2, Homer3). Homer3 can regulate transcription and play a very important role in the differentiation and development for some tissues (e.g.

Improved chromatographic fingerprints for facile differentiation of two Ganoderma spp.

This paper addresses a comprehensive and comparative study of six phytochemical extraction methods for triterpenes from the fruiting body of Ganoderma spp. Quantitative analysis of extracts was performed by HPLC with photodiode array detection. In general, pressurized liquid extraction and microwave-assisted extraction under optimized conditions produce better yields, and the former also significantly reduces the total time of extraction and manipulation of a sample, as well as the amount of solvent used in comparison with conventional soxhlet, reflux, ultrasonic, and methanol-CO(2) supercritical fluid extractions.

[Analysis of dencichine by HPLC with pre-column derivatization].

Objective: To establish a reversed-phase high performance liquid chromatorgraphy (RP-HPLC) method for detecting the dencichine in Panax notoginseng extracts and drug preparations.

Method: Dencichine was extracted with the borate buffer (pH 9. 18) and the clear supernatant was used for the derivatization.

[Survey on the utilization of narcotic analgesics].

Unlabelled: To evaluate the prescription of narcotic analgesics by the medical staff of Nanfang Hospital.

Methods: Drug utilization index (DUI) was used to analyze the prescriptions of narcotic analgesics to both in- and out-patients in the year of 2000.

Results: Six kinds of narcotic analgesics were prescribed mostly to relieve renal biliary colic, cancer pain and cough in the year 2000 in Nanfang Hospital.