Bone morphogenetic protein and activin membrane-bound inhibitor overexpression inhibits gastric tumor cell invasion via the transforming growth factor-β/epithelial-mesenchymal transition signaling pathway.

Gastric carcinoma is one of the most common human malignancies and remains the second leading cause of cancer-associated mortality worldwide. Gastric carcinoma is characterized by early-stage metastasis and is typically diagnosed in the advanced stage. Previous results have indicated that bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) overexpression has been demonstrated to inhibit growth and metastasis of gastric cancer cells.

GP73 level determines chemotherapeutic resistance in human hepatocellular carcinoma cells.

GP73 is a new hepatocellular carcinoma (HCC) marker, which is highly expressed in hepatocellular carcinoma and closely relates to prognosis. This study was to investigate the effects of GP73 on cellular proliferation, apoptosis, oxaliplatin (OXA) resistance and secretory clusterin (sCLU) of HCC cells. Western blot and immunofluorescence was used to detect the expression of GP73 in 8 types of commonly used HCC cell lines.

APE1 overexpression is associated with poor survival in patients with solid tumors: a meta-analysis.

APE1 is known as a key mediator of DNA damage repair pathways, and its clinical significance in different types of cancer is well studied. Herein, we performed a meta-analysis to determine the association of APE1 expression and survival in different types of solid cancer. We searched all eligible publications in PubMed, Web of Science and Embase platforms from inception to January 2017 and found 15 relevant manuscripts.

The clinical significance and biological function of large tumour suppressor 2 in hepatocellular carcinoma.

Objectives: Present evidence has suggested that large tumour suppressor 2 (LATS2) is abnormally expressed in most human cancer. However, the clinical and prognostic value in hepatocellular carcinoma (HCC) is still unknown.

Materials And Methods: Large tumour suppressor 2 mRNA and protein expression levels in HCC tissues and cell lines were detected by qRT-PCR, immunohistochemistry or Western blot.

Intraperitoneal Perfusion Therapy of Endostar Combined with Platinum Chemotherapy for Malignant Serous Effusions: A Meta-analysis.

Background: Malignant serous effusions (MSE) are one complication in patients with advanced cancer. Endostar is a new anti-tumor drug targeting vessels which exerts potent inhibition of neovascularization. This study aimed to systematically evaluate the efficacy and safety of intraperitoneal perfusion therapy of Endostar combined with platinum chemotherapy for malignant serous effusions (MSE).

Clinical efficacy of bevacizumab concomitant with pemetrexed in patients with advanced non-small cell lung cancer.

Objective: To observe the clinical efficacy of bevacizumab concomitant with pemetrexed in patients with advanced non-small cell lung cancer (NSCLC).

Materials And Methods: A total of 72 patients were randomly divided into a combination group (pemetrexed+bevacizumab, n=36) and a pemetrexed group (n=36) and assessed for disease control (CR+PR+SD) after 4-cycles of first-line GP chemotherapy (gemcitabine+cisplatin). Clinical efficacy, progression-free survival time (PFS), overall survival time (OS), overall response rate (ORR), disease control rate (DCR) and rate of adverse responses between two groups were observed and compared.

[Study on preparation of total flavones in Glechoma longituba sustained-release tablets and its in vitro release].

Objective: To study the preparation of total flavones in Glechoma longituba sustained-release tablets and evaluate its releasing features in vitro.

Methods: Orthogonal experiment (L(9)3(4)) was used to optimize the process of preparation of total flavones in Glechoma longituba sustained-release tablets. Investigated the release effect in vitro of optimization test result.

[Studies on purification process of total flavones from Glechoma longituba with macroporous adsorption resin].

Objective: To study the purification process of total flavones from Glechoma longituba with macroporous adsorption resin.

Methods: The eluting power and purified ratio of total flavones were selected as indices, the adsorbility and eluting parameters of the process were studied.

Results: The best result that the purity of total flavones from Glechoma longituba could reach 68.

[Circulated extraction of flavonoids from Glechoma longituba by ultrasonic wave].

Objective: To investigate the optimum condition of extraction for the flavonoids in Glechoma longituba by ultrasonic wave.

Method: Using orthogonal test, the effects of ultrasonic power, ultrasonic time, extraction temperature and solvent concentration were considered, the comprehensive evaluation was guided by the content of the flavonoids determined by ultraviolet spectrophotometer.

Result: The optimum condition was as follow: ultrasonic power; 800 W, ultrasonic time 90 min, extraction temperature 40 degrees C, solvent concentration 65%.