Publications by authors named "Chun-Ling Wang"
Article Synopsis
- The study investigates how ferroptosis, a type of cell death linked to oxidative stress, contributes to radiation-induced pulmonary fibrosis through the Nrf2/SLC7A11/GPX4 signaling pathway.
- Fifty Wistar rats were divided into groups, with some subjected to radiation to create a model of lung fibrosis and others given extracts from Angelicae Sinensis Radix and Astragali Radix for 30 days.
- Results indicated that radiation significantly impacted lung tissue by increasing markers of oxidative stress (like Fe²⁺ and MDA), while damaging lung structure and raising levels of reactive oxygen species, suggesting potential therapeutic effects of the herbal extracts.
[Analysis of Factors Influencing Overall Survival and Prognosis of AML Patients Over 50 Years Old].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2024
Objective: To explore the overall survival and prognostic factors of patients over 50 years old with acute myeloid leukemia (AML).
Methods: The clinical data of 222 AML patients aged over 50 years in our hospital from January 2016 and June 2021 were retrospectively analyzed. Kaplan-Meier method was used to evaluate the overall survival (OS) rate, and Cox regression model to evaluate the prognostic factors.
Article Synopsis
- Scientists wanted to see if combining arsenic compounds with a medicine called imatinib could help people with chronic myeloid leukemia (CML) better than just using imatinib alone.
- They did a study with 191 patients who were recently diagnosed, giving some a mix of arsenic and imatinib while others got a placebo with imatinib.
- After following the patients for over four years, they found that while both treatments worked similarly, the combination treatment might help more people achieve better results after 12 months.
[Real-World Efficacy and Safety of China-Made Flumatinib Mesylate in the Treatment of Chronic Myeloid Leukemia in Chronic Phase].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2024
Article Synopsis
- * It involved 42 patients, 14 of whom were newly diagnosed, and results showed significant positive responses after 3, 6, and 12 months of treatment, including complete hematological responses in the majority of patients.
- * The research concluded that flumatinib mesylate demonstrated strong short-term effectiveness and a manageable safety profile in patients, whether used as a first-line treatment or during conversion from other therapies.
Objective: To observe the efficacy and safety of CLAE intensive chemotherapy followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with relapsed/refractory acute leukemia (R/R AL).
Methods: CLAE regimen [cladribine 5 mg/(m·d), d 1-5; cytarabine 1.5 g/(m·d), d 1-5; etoposide 100 mg/(m·d), d 3-5] followed by allo-HSCT was used to treat 3 R/R AL patients.
[Effect of CXCR4 on the Treatment Response and Prognosis of Carfilzomib in Multiple Myeloma].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
April 2022
Article Synopsis
- The study investigates how the CXCR4 gene influences the effectiveness of Carfilzomib (CFZ) treatment in patients with multiple myeloma (MM).
- Researchers analyzed data from CFZ-resistant and parental MM cell lines to identify key genes related to CFZ resistance using microarray data and protein-protein interaction networks.
- Findings reveal that high levels of CXCR4 expression are linked to increased relapse rates and decreased overall survival in MM patients, suggesting CXCR4 could be a target for improving treatment responses in resistant cases.
[Efficacy of Micro-Transplantation Consolidation Therapy for Patients with Acute Myeloid Leukemia after Complete Remission].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
April 2021
Objective: To investigate the efficacy and safety of micro-transplantation in acute myeloid leukemia (AML).
Methods: The clinical data of 13 adult AML patients who received micro-transplantation as consolidation therapy from July 2014 to October 2019 was retrospectively analyzed, and the adverse reactions and efficacy of micro-transplantation were followed up.
Results: Eight patients received micro-transpantation were still in complete remission, 5 patients relapsed after micro-transplantation, 1 of them received umbilical cord blood micro-transplantation after remission by reinduction, and all of the 13 patients have survived till now.
[Significance of Targeted Sequencing Assay for Patients with Suspected Myeloid Malignancies].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2020
Article Synopsis
- The study aimed to evaluate the importance of a targeted next-generation sequencing test for diagnosing myeloid malignancies in patients with blood disorders.
- A total of 39 patients were analyzed, with 70.8% of those diagnosed with myeloid malignancies showing positive mutations, particularly in genes like ASXL1, TET2, and RUNX1.
- The findings indicated that the targeted sequencing can enhance diagnosis and potentially guide treatment for patients, especially for those with myelodysplastic syndromes.
[Clinical Analysis of 66 Patients with Essential Thrombocytopenia].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2020
Article Synopsis
- The study aimed to analyze clinical characteristics of 66 newly diagnosed essential thrombocytopenia (ET) patients, focusing on their mutation status (JAK2, CALR, MPL, or none).
- Results showed that 69.7% had JAK2 mutations, with the average age significantly higher (63.2 years) than those with CALR mutations (51.8 years) or negative mutations (50.2 years).
- The CALR mutation group exhibited lower white blood cell (WBC) and hemoglobin (Hb) levels, while 30.3% of all patients experienced thrombus or embolism, with some also facing complications like hyperkalemia.
[Therapeutic Response and Prognosis of Adult Acute Myeloid Leukemia with Chromosome Karyotype Abnormalities].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2019
Article Synopsis
- The study aimed to analyze the effectiveness and prognosis of acute myeloid leukemia (AML) patients based on chromosome karyotype abnormalities by investigating clinical features and treatment responses in 91 patients.
- Results showed that while there was no significant difference in complete remission and overall response rates between patients with normal and abnormal karyotypes, those with abnormal karyotypes experienced higher recurrence rates and longer relapse-free survival for normal karyotype patients.
- The conclusion drawn indicates that having an abnormal karyotype is an independent prognostic factor in AML, with a particular mention that monosomal karyotypes are associated with poorer outcomes and higher recurrence rates.
Article Synopsis
- Characterizing the functions of short protein sequences is a complex problem that researchers are aiming to solve.
- The authors suggest mapping the physicochemical properties of amino acids onto unit spheres for quantitative representation of protein sequences.
- Their approach shows improved prediction of cell-penetrating peptides and is accessible via a web server for automatic calculations of the features.
Chitinophaga flava sp. nov., isolated from monsoon evergreen broad-leaved forest soil.
Int J Syst Evol Microbiol
March 2019
A Gram-stain-negative, aerobic, non-motile strain, K3CV102501, was isolated from a soil sample collected from the monsoon evergreen broad-leaved forest of Dinghushan Biosphere Reserve located in Guangdong Province, PR China. The primal colony of strain K3CV102501 was very similar to the fruiting body of myxobacteria on the original isolation plates. Young cultures of strain K3CV102501 contained long (2-4×0.
View Article and Find Full Text PDFAim: The purpose of this study was to investigate the possible mechanisms of genistein (GEN) and daidzein (DAI) in inducing apoptosis of colon cancer cells by inhibition of lipid droplets (LDs) accumulation.
Methods: HT-29 cells were used and treated by GEN or DAI in this paper. LDs accumulation was induced and inhibited by oleic acid (OA) and C75, respectively.
Article Synopsis
- The study investigates the effect of Danshen extract on levels of Lp-PLA, a biomarker linked to increased coronary artery disease risk, in patients with stable angina pectoris.
- It involves a randomized, single-blind, placebo-controlled design with 156 participants, who will either receive Danshen extract or placebo during hospitalization and then an open-label treatment after discharge.
- Primary outcomes include changes in serum Lp-PLA levels, while secondary outcomes focus on improvements in angina frequency and carotid intima-media thickness, with the potential to provide evidence for the benefits of Danshen extract in treating stable angina.
[Differential Regulation of Bruton's Tyrosine Kinase by the Ubiquitin Pathway].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2017
Article Synopsis
- The study aimed to understand how Bruton's tyrosine kinase (Btk) is regulated and its underlying mechanisms.
- Researchers used various treatments to assess the mRNA and protein levels of Btk and found that its expression is influenced by factors like proteasome inhibitors and phorbol esters (PMA).
- The results indicate that Btk is regulated through ubiquitination, particularly by the E3 ligase Cbl, impacting its stability and activation in cells.
Background: Intrinsically unstructured or disordered proteins function via interacting with other molecules. Annotation of these binding sites is the first step for mapping functional impact of genetic variants in coding regions of human and other genomes, considering that a significant portion of eukaryotic genomes code for intrinsically disordered regions in proteins.
Results: DisBind (available at http://biophy.
About 90% of tuberculosis (TB) patients latently infected with Mycobacterium tuberculosis (Mtb) show no symptoms, yet have a 10% chance in lifetime to progress active TB. Nevertheless, current diagnosis approaches need improvement in efficiency and sensitivity. The objective of this work was to detect potential signatures for active TB to further improve the understanding of the biological roles of functional modules involved in this disease.
View Article and Find Full Text PDFBackground: Chronic hepatitis B (CHB) remains a major public health problem worldwide, and the prevalence of CHB patients with hepatic steatosis is gradually increasing. Noninvasive approaches for the assessment of hepatic steatosis have been developed as alternatives to liver biopsy.
Objectives: This study evaluated the diagnostic performance of the fat attenuation parameter (FAP) measured by transient elastography (FibroTouch) and a new algorithm to assess hepatic steatosis in CHB patients, in comparison to liver biopsy as the gold standard.
[Influence of Co-inhibiting mTORC2 and HSP90 on Proliferation Apoptosis of Multiple Myeloma Cells].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2016
Article Synopsis
- The study investigates how combining inhibitors of mTORC2 and HSP90 affects the growth and death of multiple myeloma (MM) cells using the U266 cell line.
- Treatment with rapamycin and 17-AAG showed that both drugs could slow down cell growth, with their combined use being more effective than each one alone or a control group.
- The findings indicate that the combination therapy not only enhances apoptosis (cell death) but also alters key protein levels, suggesting a promising strategy for treating multiple myeloma.
[Expression of Btk and NFκB in Acute Lymphoblastic Leukemia Cells and Its Significance].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2016
Article Synopsis
- The study aimed to investigate the roles of Btk and NFκB in acute lymphoblastic leukemia (ALL) by analyzing their expression levels in leukemia cells from patients.
- Results showed that higher levels of Btk and NFκB were found in newly diagnosed ALL patients compared to those in remission, indicating a correlation with disease progression.
- The findings suggest that Btk and NFκB could be important targets for therapy and useful indicators for predicting outcomes in ALL.
Article Synopsis
- Microencapsulation enhances the survival of probiotics like Lactobacillus rhamnosus GG (LGG) in challenging gastrointestinal conditions and while stored in yogurt.
- The method involves cross-linking soy protein isolate using transglutaminase, embedding the bacteria, and freeze-drying, achieving a high encapsulation yield of 67.4%.
- Results show microencapsulated LGG outperforms free cells in survival rates under harsh conditions such as low pH and bile salts, with 14.5% survival during yogurt storage.
Article Synopsis
- Eukaryotic cells have a response mechanism called the endoplasmic reticulum stress (ERS) response to manage unfolded proteins, mainly involving the protein kinase PERK, which regulates protein synthesis through eIF2α phosphorylation.
- The study focuses on how the PERK-eIF2α-ATF4 signaling pathway influences the osteogenic differentiation of periodontal ligament cells (PDLCs) when subjected to mechanical forces, simulating orthodontic treatment.
- Results showed that applying cyclic mechanical force enhances the expression of osteoblast markers and promotes differentiation via this signaling pathway, while PERK knockout cells exhibited inhibited differentiation, highlighting the pathway’s crucial role.
Article Synopsis
- A genome-shuffled strain of Candida versatilis S3-5 was tested for its fermentation performance during soy sauce production compared to a wild-type strain.
- The S3-5 strain produced ethanol more rapidly and in larger quantities than the WT, along with higher levels of organic acids like malic, citric, and succinic acids.
- Additionally, S3-5 generated significantly more flavor compounds, particularly esters, suggesting it has better metabolic capabilities and could be beneficial as a salt-tolerant yeast in fermentation processes.
Most natural protein sequences have resulted from millions or even billions of years of evolution. How they differ from random sequences is not fully understood. Previous computational and experimental studies of random proteins generated from noncoding regions yielded inclusive results due to species-dependent codon biases and GC contents.
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