Pd-Catalyzed Remote Site-Selective and Stereoselective C(Alkenyl)-H Alkenylation of Unactivated Cycloalkenes.

A palladium-catalyzed alkenylation involving remote δ-position C(alkenyl)-H activation of cycloalkenes reacting with electron-deficient alkenes is described. This method features excellent site selectivity and stereoselectivity to efficiently afford only -selective highly substituted 1,3-diene derivatives with extra-ligand-free and good functional group tolerance including estrone and free N-H tryptamine under weakly alkaline conditions. Mechanistic studies suggest that picolinamide as a bidentate directing group enables the formation of unique alkenyl palladacycle intermediates.

[Identification on Herba Hyperici Japonici and its adulterant].

Objective: To study the identification of Herba Hyperici Japonici and its adulterant.

Methods: Herba Hyperici Japonici and Herba Hyperici graminei were identified by traditional and modern identification.

Results: Both of them showed difference in exterior character, microscope characteristic, TLC, UV and HPLC fingerprint graphics.

[Application of reversed pedicled submental island flap].

Objective: To explore the clinical applications of reversed pedicled submental island flap in the face and oropharynx.

Methods: The clinical data of ten cases of reconstruction of defect in the area of face or oropharynx following resection of tumors with reversed pedicled submental island flaps between January of 2004 to December of 2006 were retrospectively studied. The cases included six males and four females, aged from 24 to 76 (median 55 years).