Publications by authors named "Chun-Jun Yang"
Article Synopsis
- CAP-activated saline (CAP-AS) treatment improves recovery and motor function in mice with spinal cord injuries compared to untreated controls.
- Transcriptome analysis reveals that CAP-AS affects gene expression related to extracellular matrix and immune response, suggesting mechanisms behind its protective effects.
- Treatment with CAP-AS reduces inflammation, decreases macrophage infiltration, and promotes tissue healing, as seen through various histological and cytokine assessments.
Aim: To observe the effect of the implementation of improved high-risk sign boards for older people inpatients.
Method: The older people inpatients of the Department of Geriatrics at our hospital were selected as the research subjects and divided into two groups. The control group used the single-strip high-risk sign, and the intervention group used the improved double-layer card slot, push-pull integrated high-risk sign board (national patent).
Objective: Based on the social-ecological model, this study aimed to comprehensively explore factors affecting the risk of ischemic cerebrovascular disease (ICVD) in postmenopausal women to provide theoretical bases for further prevention and intervention for postmenopausal women.
Methods: Postmenopausal women who underwent medical examinations in one health-checkup agency in Tianjin from May 2015 to October 2015 were enrolled in this study. The ICVD 10-year Risk Assesment Form developed by the research team of the National "Tenth Five-Year Plan" research project was used to assess the factors affecting the risk of ICVD.
Cutaneous squamous cell carcinoma (CSCC), a class of skin tumor derived from epidermal keratinocyte, is reputed as one of the most malignant tumors globally. MicroRNAs (miRNAs) are increasingly identified as essential players in CSCC. Current study aimed to uncover the impact and mechanism of miR-1193 in CSCC.
View Article and Find Full Text PDFMiRNAs were involved in the various biological process through mediating the posttranscriptional gene silencing. The abnormal expression of miRNAs is also involved in various disorders. Our previous study showed that miRNA-27a (miR-27a) was upregulated after ultraviolet B (UVB) irradiation.
View Article and Find Full Text PDFThis systematic review is to explore the prevalence of depression in patients with rheumatoid arthritis (RA) in China. Articles of prevalence rates for depression in adult RA patients published before October 2015 were identified from PubMed, Embase, The Cochrane Library, CNKI, CBM, VIP, and Wanfang database and other internet databases. Relevant journals and the recommendations of expert panels were also searched manually.
View Article and Find Full Text PDFObjective: Interleukin 29 (IL-29) is a class II cytokine and displays numerous immune functions other than its anti-viral and antiproliferation activities. This study is focused on the effect of IL-29 on human keratinocytes (KCs).
Methods: Primary KCs were stimulated by various concentrations of IL-29 for different time periods, and antiviral proteins and TLR3 gene expression were then analyzed by real-time PCR.
Article Synopsis
- Atopic dermatitis is a long-lasting inflammatory skin condition influenced by both genetics and the environment.
- A study involved a genome-wide analysis of atopic dermatitis in a large Chinese Han population and included additional samples from Germany, leading to the identification of new genetic markers associated with the condition.
- The findings reveal new potential genetic factors that contribute to atopic dermatitis and suggest new biological pathways that could be explored for better understanding and treatment.
Article Synopsis
- A genome-wide association study (GWAS) was conducted on systemic lupus erythematosus (SLE) in a Chinese Han population, involving over 1,000 cases and 1,200 controls, with genetic analysis performed using Illumina technology.
- The study identified nine new genetic susceptibility loci for SLE and confirmed seven previously known loci, showing a significant difference in genetic factors contributing to SLE between Chinese Han and European populations.
- Findings from this research enhance the understanding of SLE's genetic basis and emphasize the importance of studying diverse populations in genetic research.
We report the first large genome-wide association study (GWAS) in a Chinese population to identify susceptibility variants for psoriasis using a two-stage case-control design. In the first stage, we carried out a genome-wide association analysis in 1,139 cases and 1,132 controls of Chinese Han ancestry using Illumina Human 610-Quad BeadChips. In the second stage, we took top SNPs forward for replication in two independent samples of 5,182 cases and 6,516 controls of Chinese Han ancestry, and 539 cases and 824 controls of Chinese Uygur ancestry.
View Article and Find Full Text PDFThe treatment and relapse rate of genital warts are significant problems. The aim of this observational study was to assess the efficacy of holmium laser treatment of genital warts. A total of 1500 outpatients with genital human papillomavirus-induced lesions presenting from August 2002 to June 2005 were treated with holmium laser.
View Article and Find Full Text PDFFetal outcome following roxithromycin exposure in early pregnancy.
J Matern Fetal Neonatal Med
March 2006
Objective: Because very little information exists on the fetal safety of roxithromycin, we aimed to extend the knowledge on fetal outcome in pregnant women who were exposed to roxithromycin in early pregnancy.
Methods: Twenty pregnant women inadvertently exposed to roxithromycin during early pregnancy were identified and prospectively followed-up. For comparison, 170 pregnant women matched by age and gravidity, not being exposed to any potential teratogenic agent during pregnancy, were recruited as controls.