Publications by authors named "Chun-Hua Fang"
Article Synopsis
- A study was conducted on renal transplant recipients to understand how voriconazole affects tacrolimus levels, as there was no existing model for this interaction.
- The research involved 19 patients and used population pharmacokinetic analysis with blood samples to create a model showing how different factors, especially voriconazole levels and kidney function, affect tacrolimus dosing.
- The results indicated that tacrolimus dosage can be optimized based on voriconazole concentration and serum creatinine, with voriconazole having a stronger impact on tacrolimus levels.
Tacrolimus is an immunosuppressant with a narrow therapeutic window. Tacrolimus exposure increased significantly during voriconazole co-therapy. The magnitude of this interaction is highly variable, but it is hard to predict quantitatively.
View Article and Find Full Text PDFLiver fibrosis is characterized by the transdifferentiation of hepatic stellate cells (HSCs) to myofibroblasts and poor response to treatment. This can be attributed to the myofibroblast-specific resistance to phenotype reversal. In this study, we complemented miR-16 into miR-16-deficient myofibroblasts and analyzed the global role of miR-16 using transcriptome profiling and generating a pathway-based action model underlying transcriptomic regulation.
View Article and Find Full Text PDFMatrine is one of the main active components that is extracted from the dry roots of . The compound has potent antitumor activity in various cancer cell lines. However, the anticancer activity of matrine in colon cancer cells remains unclear.
View Article and Find Full Text PDF[Slowing progression of chronic allograft nephropathy by conversion from cyclosporin A to tacrolimus].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
February 2007
Objective: To investigate the feasibility and safety of substituting tacrolimus(FK506) for cyclosporin A(CsA) on delaying the pace of renal dysfunction in patients with biopsy-proven chronic allograft nephropathy(CAN).
Methods: Seventy-three renal transplantation patients with CAN proved by allograft biopsy were collected in this study. Patients were randomly divided into 2 groups.