Publications by authors named "Chun-Han Huang"
The synthesis, biochemical evaluation and radiosynthesis of a cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor and radioligand was performed. NT431, a newly synthesized 4-fluorobenzyl-abemaciclib, exhibited high potency to CDK4/6 and against four cancer cell lines with IC similar to that of the parent abemaciclib. We performed a two-step one-pot radiosynthesis to produce [F]NT431 with good radiochemical yield (9.
View Article and Find Full Text PDFThe design and radiosynthesis of [F]NT376, a high potency inhibitor of class-IIa histone deacetylases (HDAC) is reported. We utilized a three-step radiochemical approach that led to the radiosynthesis of [F]NT376 in a good radiochemical yield, (17.0 ± 3%, decay corrected), high radiochemical purity (> 97%) and relatively high molar activity of 185.
View Article and Find Full Text PDFWe utilized positron emission tomography (PET) imaging in vivo to map the spatiotemporal biodistribution/expression of class-IIa histone deacetylases (class-IIa HDACs) in the central nervous system (CNS). Herein we report an improved radiosynthesis of [F]NT160 using 4-hydroxy-TEMPO which led to a significant improvement in radiochemical yield and molar activity. PET imaging with [F]NT160, a highly potent class-IIa HDAC inhibitor, led to high-quality and high-contrast images of the brain.
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- - Guillain-Barré syndrome (GBS) can arise after infections, but it's also rare after elective spinal surgeries, as shown in a case of an 87-year-old man who developed GBS following surgery for a cervical spinal cord injury.
- - Post-surgery, the patient initially experienced weakness and numbness in all limbs, which gradually worsened, leading to near-total paralysis and respiratory failure, as confirmed by cerebrospinal fluid (CSF) and nerve conduction studies.
- - Despite the diagnosis of GBS, the patient's family opted against immune-modulatory treatment, resulting in a poor prognosis, highlighting the need to consider GBS in similar postoperative situations, especially in patients with spinal conditions.
Increasing frequency of human exposure to PEG-related products means that healthy people are likely to have pre-existing anti-PEG antibodies (pre-αPEG Ab). However, the influence of pre-αPEG Abs on the pharmacokinetics (PK) and therapeutic efficacy of LipoDox is unknown. We generated two pre-αPEG Ab mouse models.
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